Fibrinolysis

Question 1

Final stage of coagulation, begins a few hours after fibrin polymerization and cross-linking

Answer 1

Fibrinolysis

Question 2

Dissolution of clot by plasmin

Answer 2

Fibrinolysis

Question 3

This is derived from plasminogen, which is produced by the liver

Answer 3

Plasmin

Question 4

2 activators of fibrinolysis:

Answer 4

Tissue-type plasminogen activator (TPA) and Urokinase-type plasminogen activator (UPA)

Question 5

They are released in response to inflammation and coagulation

Answer 5

TPA and UPA

Question 6

Body’s defense against occlusion of blood vessels

Answer 6

Fibrinolysis

Question 7

Remove minute clots from millions of tuny peripheral nerves

Answer 7

Fibrinolysis

Question 8

Normally present in plasma, converted to plasmin by action of plasminogen activators

Answer 8

Plasminogen

Question 9

A single-chain protein possessing five glycosylated loops

Answer 9

Kringles

Question 10

Primary substance involved with the fibrinolytic system not normally found in circulation

Answer 10

Plasmin

Question 11

Main proteolytic enzyme in fibrinolysis, also called fibrinolysin

Answer 11

Plasmin

Question 13

Cleaves the fibrin clots, the product of coagulation

Answer 13

Plasmin

Question 14

accomplished by the enzyme plasmin that digests the fibrin
strands of the clot as well as several clotting factors.

Answer 14

Plasminogen activator inhibitor 1 (PAI-1)

Question 15

synthesized in the liver and is the primary inhibitor of free plasmin

Answer 15

a2-Antiplasmin (AP)

Question 16

a serine protease inhibitor with the unique characteristic of both N- and C-terminal extensions.

Answer 16

a2-Antiplasmin

Question 17

plasma procarboxypeptidase synthesized in the liver
that becomes activated by the
thrombin-thrombomodulin complex.

Answer 17

Thrombin-Activable Fibrinolysis Inhibitor (TAFI)

Question 18

It inhibits fibrinolysis by cleaving exposedcarboxy-terminal lysine residues from partially degraded fibrin, thereby preventing the binding of TPA and plasminogen to fibrin and blocking the formation of plasmin

Answer 18

Thrombin-Activable Fibrinolysis Inhibitor (TAFI)

Question 19

This system is activated by both the coagulation and
fibrinolytic systems

Answer 19

Kinin System

Question 20

Kinin System Factors:

Answer 20

• Prekallikrein
• Kallikrein
• Kininogen
• Kinins

Question 21

Principal inhibitor of coagulation

Answer 21

Anti-thrombin III (AT III)

Question 22

Vitamin K dependent regulatory proteins:

Answer 22

Proteins C and S

Question 23

Inhibit factor VIIa-tissue factor complex

Answer 23

Tissue factor pathway inhibitor

Question 24

Inhibits thrombin, Xa, kallikrein, and plasmin

Answer 24

Alpha-2 macroglobulin

Question 25

Inhibits XIa and inactivates plasmin

Answer 25

Alpha-1 Antitrypsin

Question 26

Inhibits C1 from the complement cascade and XIIa, XIa, kallikrein and plasmin

Answer 26

C1 Inhibitor

Question 27

Prevention of blood loss

Answer 27

Hemostasis

Question 28

Step of Hemostasis:

Answer 28

1. Vasoconstriction
2. Temporary Platelet Plug/ Primary Hemostasis
3. Coagulation/Secondary Hemostasis
4. Fibrinolysis
5. Regeneration of cells

Question 29

End result of Primary Hemostasis:

Answer 29

Platelet Plug Formation

Question 30

Extrinsic Pathway is tested/measured by:

Answer 30

Prothrombin Time

Question 31

Extrinsic factor is activated by:

Answer 31

Tissue factor

Question 32

Extrinsic pathway inhibitor:

Answer 32

Warfarin

Question 33

Intrinsic pathway is tested/measured by:

Answer 33

PTT/aPTT

Question 34

Intrinsic pathway is activated by:

Answer 34

Subendothelial collagen

Question 35

Intrinsic pathway inhibitor:

Answer 35

Heparin

Question 36

Common pathway is activated by:

Answer 36

Extrinsic and Intrinsic Pathway

Question 37

Common pathway is tested by:

Answer 37

PT/APTT

Question 38

Primary hemostasis tests:

Answer 38

Platelet count, Bleeding time, Platelet aggregometry