Hemopoetic Flashcards
Type of von willbrand disease that occurs in a person with wilms tumor and, congenital heart disease, systemic lupus erythematosus, and hypothyroidism
Acquired type con willbrand disease
One of the substances the body uses to activate platelets. It leads to aggregation.
adenosine diphosphate
The most abundant mineral in the body. Necessary for bone and teeth formation, muscle contractility, coagulation, and other body processes
calcium
Under the influence of this substance, the blood vessels quickly vasoconstricts, reflexively, when a vessel is injured.
endothelin
Hormone that is produced by the kidney that promotes the formation of red blood cells in the bone marrow.
erythropoietin
An insoluble protein that strengthens the platelet plug . It is derived from fibronogen
fibrin
Released by platelets along with calcium, the substance is necessary for secondary homeostasis.
fibronogen
While the red blood cells are developing, this substance and vitamin b 12 are necessary in addition to EPO. They are necessary for cellular DNA synthesis.
folic acid.
Under normal circumstances, this substance and prostacyclin block platelets from adhering to the cell membrane; it is also secreted by the endothelial cells
nitric oxide
Under normal circumstances , this substance and nitric oxide block platelets from adhering to the cell membrane; its also secreted by the endothelial cells
prostacyclin
A neurotransmitter released by platelets in the clotting process, that acts as a vasodilator
serotonin
This enzyme mediates conversions of fibrinogen to fibrin through activation of the coagulation cascade. This process represents secondary hemostasis
thrombin
A potent vasodilator that acts in opposition to prostacyclin. It promotes further platelet aggregation.
thromboxane A2
The most common (70-80%) and mildest form con willebrand disease. It follows an autosomal dominant inheritance pattern. The level of Von willebrand factor in the blood is reduced. It is often very mild and most cases go undiagnosed.
Type 1 von willebrand disease.
This form of von willebrand disease that occurs in 15-20% of cases. It can be either autosomal dominant or recessive and four subtypes exist. The building blocks that make up the von willebrand factor are smaller than usual and break down easily . Bleeding is usually moderate or severe
Type 2 von willebrand disease
This form of von willebrand disease follows and autosomal recessive inheritance pattern. Severe bleeding problems are seen with this type due to lack of measurable von willebrand factor and factor 8. It is the rarest form.
Tye 3 von willebrand disease
While the red blood cell is developing, this substance and folic acid are necessary in addition to EPO. They are necessary for cell DNA synthesis
Vitamin B 12
A factor secreted by the endothelial lining, which in response to injury binds to the basement membrane.
von willebrand factor
A common form of sickle cell disease, with hemoglobin sc
a2 cs2
A common and severe form of sickle cell disease, with hemoglobin ss
a2 bs2
