Hemopoetic Flashcards

1
Q

Type of von willbrand disease that occurs in a person with wilms tumor and, congenital heart disease, systemic lupus erythematosus, and hypothyroidism

A

Acquired type con willbrand disease

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2
Q

One of the substances the body uses to activate platelets. It leads to aggregation.

A

adenosine diphosphate

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3
Q

The most abundant mineral in the body. Necessary for bone and teeth formation, muscle contractility, coagulation, and other body processes

A

calcium

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4
Q

Under the influence of this substance, the blood vessels quickly vasoconstricts, reflexively, when a vessel is injured.

A

endothelin

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5
Q

Hormone that is produced by the kidney that promotes the formation of red blood cells in the bone marrow.

A

erythropoietin

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6
Q

An insoluble protein that strengthens the platelet plug . It is derived from fibronogen

A

fibrin

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7
Q

Released by platelets along with calcium, the substance is necessary for secondary homeostasis.

A

fibronogen

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8
Q

While the red blood cells are developing, this substance and vitamin b 12 are necessary in addition to EPO. They are necessary for cellular DNA synthesis.

A

folic acid.

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9
Q

Under normal circumstances, this substance and prostacyclin block platelets from adhering to the cell membrane; it is also secreted by the endothelial cells

A

nitric oxide

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10
Q

Under normal circumstances , this substance and nitric oxide block platelets from adhering to the cell membrane; its also secreted by the endothelial cells

A

prostacyclin

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11
Q

A neurotransmitter released by platelets in the clotting process, that acts as a vasodilator

A

serotonin

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12
Q

This enzyme mediates conversions of fibrinogen to fibrin through activation of the coagulation cascade. This process represents secondary hemostasis

A

thrombin

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13
Q

A potent vasodilator that acts in opposition to prostacyclin. It promotes further platelet aggregation.

A

thromboxane A2

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14
Q

The most common (70-80%) and mildest form con willebrand disease. It follows an autosomal dominant inheritance pattern. The level of Von willebrand factor in the blood is reduced. It is often very mild and most cases go undiagnosed.

A

Type 1 von willebrand disease.

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15
Q

This form of von willebrand disease that occurs in 15-20% of cases. It can be either autosomal dominant or recessive and four subtypes exist. The building blocks that make up the von willebrand factor are smaller than usual and break down easily . Bleeding is usually moderate or severe

A

Type 2 von willebrand disease

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16
Q

This form of von willebrand disease follows and autosomal recessive inheritance pattern. Severe bleeding problems are seen with this type due to lack of measurable von willebrand factor and factor 8. It is the rarest form.

A

Tye 3 von willebrand disease

17
Q

While the red blood cell is developing, this substance and folic acid are necessary in addition to EPO. They are necessary for cell DNA synthesis

A

Vitamin B 12

18
Q

A factor secreted by the endothelial lining, which in response to injury binds to the basement membrane.

A

von willebrand factor

19
Q

A common form of sickle cell disease, with hemoglobin sc

A

a2 cs2

20
Q

A common and severe form of sickle cell disease, with hemoglobin ss

A

a2 bs2