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Pathology > HemOnc > Flashcards

HemOnc Flashcards

1
Q

kallikrein

A

needs 12a

makes plasmin/bradykinin

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2
Q

hemophilia test

A

PTT

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3
Q

direct thrombin inhibitors

A 
lepirudin
bivalirudin
desirudin
argatroban
dabagatron
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4
Q

factor Xa inhibitors

A

rivaroxaban

apixaban

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5
Q

warfarin vs. heparin

A

warfarin is longer, slower, increases PT

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6
Q

HIT

A

Ab to platelet factor 4

treat with direct thrombin inhibitor early until warfarin builds up

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7
Q

teardrop RBC

A

myelofibrosis

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8
Q

degma cell

A

bite cell

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9
Q

target cell

A 
THAL
thalessemia
hemophilia C
aplenia
liver disease (also spurs)
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10
Q

spur cells

A

liver disease

abetalipoproteinemia

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11
Q

burr cell

A

uremia

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12
Q

wine urine, pain, neuro

A

acute intermittent porphyria
-UP1 synthase/porphyrobil. deaminase

get from metaclopromide, rifampin, seizure Tx

treat with glucose, heme

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13
Q

porphyria cutanea tarda

A

uroporphyrinogen decarboxylase

tea urine, hairy, blisters
Hep C, alcohol, and LFT

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14
Q

high protoporphyrin

A

lead poisoning

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15
Q

3/4 alpha thalassemia

A

HbH = B4

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16
Q

high Fe and ferritin

A

sideroblastic anemia
give B6

or hemochromatosis

17
Q

orotic aciduria

A

UMP synthase deficiency
macrocytic anemia
normal ammonia

18
Q

macrocytic normoblastic

A

5FU
ziduvudine
hydroxyurea

19
Q

paroxysmal nocturnal hematuria

A

missing CD55/59
complement attack
positive acid lysis Ham’s test

20
Q

warm agglutinins

A

IgG
lupus
EBV, CLL (also cold)

21
Q

pyruvate DH deficiency

A

neurological

22
Q

Direct Coombs

A

antihuman Ab added to patient RBC

positive in HD of newborn, drug induced hemolysis, transfusion reactions

23
Q

Indirect Coombs

A

patient serum added to normal RBC

screen transfusion, maternal Ab to fetus screen

24
Q

normal PT/PTT

A

aspirin

25
Q

high PTT, high bleeding time

A

von Willebrand disease - fail to stabilize 8

treat with DDAVP

26
Q

deficient ADAMS 13

A 
= TTP 
vWF active multimers
schistocytes, LDH, 
hemolysis, renal insuff, thrombocytopenia (HUS)
\+ neuro, fever
27
Q

Pelger-Heut bodies

A

myelodysplastic syndrome

“pince-nez”

28
Q

myeloproliferative disorder gene

A

JAK2

get myelofibrosis

29
Q

get leukomoid

A

TOF
Down
Kawasaki

30
Q

multiple myeloma gets

A

high Ca –> rouloux
renal insufficiency - SPEP/UPEP
anemia, back pain

31
Q

Mallory bodies

A

alcoholic liver

eosinophilic cytoplasmic globules in liver

32
Q

CD13/33

A

AML

33
Q

15;17

A

AML M3

auer rods

34
Q

8;21

A

AML

Downs

35
Q

risk for AML

A 
Fanconi
Bloom
alkylating agent chemo, radiation
benzene
myeloproliferative
myelodysplastic
36
Q

CLL

A

70 yo
B cell markers
autoimmune hemolytic anemia

Pathology (8 decks)

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