HemOnc

Question 1

kallikrein

Answer 1

needs 12a

makes plasmin/bradykinin

Question 2

hemophilia test

Answer 2

PTT

Question 3

direct thrombin inhibitors

Answer 3

lepirudin
bivalirudin
desirudin
argatroban
dabagatron

Question 4

factor Xa inhibitors

Answer 4

rivaroxaban

apixaban

Question 5

warfarin vs. heparin

Answer 5

warfarin is longer, slower, increases PT

Question 6

HIT

Answer 6

Ab to platelet factor 4

treat with direct thrombin inhibitor early until warfarin builds up

Question 7

teardrop RBC

Answer 7

myelofibrosis

Question 8

degma cell

Answer 8

bite cell

Question 9

target cell

Answer 9

THAL
thalessemia
hemophilia C
aplenia
liver disease (also spurs)

Question 10

spur cells

Answer 10

liver disease

abetalipoproteinemia

Question 11

burr cell

Answer 11

uremia

Question 12

wine urine, pain, neuro

Answer 12

acute intermittent porphyria
-UP1 synthase/porphyrobil. deaminase

get from metaclopromide, rifampin, seizure Tx

treat with glucose, heme

Question 13

porphyria cutanea tarda

Answer 13

uroporphyrinogen decarboxylase

tea urine, hairy, blisters
Hep C, alcohol, and LFT

Question 14

high protoporphyrin

Answer 14

lead poisoning

Question 15

3/4 alpha thalassemia

Answer 15

HbH = B4

Question 16

high Fe and ferritin

Answer 16

sideroblastic anemia
give B6

or hemochromatosis

Question 17

orotic aciduria

Answer 17

UMP synthase deficiency
macrocytic anemia
normal ammonia

Question 18

macrocytic normoblastic

Answer 18

5FU
ziduvudine
hydroxyurea

Question 19

paroxysmal nocturnal hematuria

Answer 19

missing CD55/59
complement attack
positive acid lysis Ham’s test

Question 20

warm agglutinins

Answer 20

IgG
lupus
EBV, CLL (also cold)

Question 21

pyruvate DH deficiency

Answer 21

neurological

Question 22

Direct Coombs

Answer 22

antihuman Ab added to patient RBC

positive in HD of newborn, drug induced hemolysis, transfusion reactions

Question 23

Indirect Coombs

Answer 23

patient serum added to normal RBC

screen transfusion, maternal Ab to fetus screen

Question 24

normal PT/PTT

Answer 24

aspirin

Question 25

high PTT, high bleeding time

Answer 25

von Willebrand disease - fail to stabilize 8 | treat with DDAVP

Question 26

deficient ADAMS 13

Answer 26

``` = TTP vWF active multimers schistocytes, LDH, hemolysis, renal insuff, thrombocytopenia (HUS) + neuro, fever ```

Question 27

Pelger-Heut bodies

Answer 27

myelodysplastic syndrome | "pince-nez"

Question 28

myeloproliferative disorder gene

Answer 28

JAK2 | get myelofibrosis

Question 29

get leukomoid

Answer 29

TOF Down Kawasaki

Question 30

multiple myeloma gets

Answer 30

high Ca --> rouloux renal insufficiency - SPEP/UPEP anemia, back pain

Question 31

Mallory bodies

Answer 31

alcoholic liver | eosinophilic cytoplasmic globules in liver

Question 32

CD13/33

Answer 32

AML

Question 33

15;17

Answer 33

AML M3 | auer rods

Question 34

8;21

Answer 34

AML | Downs

Question 35

risk for AML

Answer 35

``` Fanconi Bloom alkylating agent chemo, radiation benzene myeloproliferative myelodysplastic ```

Question 36

CLL

Answer 36

70 yo B cell markers autoimmune hemolytic anemia