Hemolymphatic System Flashcards
Composition of blood:
Liquid portion: plasma
Cellular portion: RBC, WBC, platelets
Characteristics of mature erythrocytes (RBC)
- Anuclear biconcave disks
- 65% water and 35% solids
Hemoglobin structure
- Heme: pigmented portion; produced by mitochondria, contains iron atoms (Fe++)
- Goblin: protein portion; produced by ribosomes.
4 heme group per goblin
Extravascular Hemolysis
- Macrophages remove senescent RBCs from circulation. RBC are broken down into components that can be recycled in the body or eliminated.
- RBC membrane destroyed
- Iron transported to red bone marrow
- AA from globin mol are transported to the liver for re-use
(there’s more i just didn’t include it)
Senescence
Process of ageing
Intravascular hemolysis
- RBCs in circulation subjected to stresses
- This can result in RBC fragmentation and/or destruction
- Hemoglobin released directly into the blood stream
Thrombocytes (platelets) functions
- Maintain vascular integrity
- Formation of platelet plugging
- Stabilize the hemostatic plug
IMPORTANT: 4. Plays a role in blood coagulation!
- No nucleus
Leukocytes (WBC) and their functions (3)
- Neutrophil: phagocytosis, fights infections.
- Basophil: Histamine (initiate inflammation) and heparin (local anticoagulant). Acute & delayed allergic reactions.
- Eosinophil: anti-inflammatory, immunity, phagocytosis.
Non-specific immune reactions
- Made up of neutrophils and macrophages.
- Ingest foreign cells/materials.
- Then pathogens are presented to the specific immune system.
Specific immunity
- Made up of memory cells, B-cells and T-cells.
- Will take pathogens presented by non-specific and create antibodies.
- Now the cells have “memory” of the pathogens.
Natural killer cells
“destroyer cells”
Come in direct contact with with tumor and tissues cells that have been invaded by viruses and destroy them
Types of immunoglobulins: (5)
- IgM: first Ig made during exposure to an antigen
- IgG: made when animals exposed to an antigen for a long time or when exposed to the antigen for the second time
- IgA: can leave blood and enter tissues fluids; plays a role in protecting mucosal surfaces
- IgE: associated with allergic responses
- IgD: function is unknown :(
GALT: Gut Associated Lymph Tissue
(This is the largest lymphoid organ in the body!)
- Lymphoid tissue found in the intestinal mucosa and submucosa
- GALT is classified as both central and peripheral lymphoid tissue
Structure, location, and function of Tonsils
- Structure: Nodules of peripheral lymphoid tissue. Not covered with a capsule
- Location: Found close to mucosal surfaces all over the body. In the beg of lymph drainage system.
- Function: In pharyngeal region prevent spread of infection into respiratory/digestive systems.
Thymus location, structure, and function
Hint: This is most prominent in young animals
- Structure: In the caudal neck and cranial thoracic region either side of the trachea.
- Location: In the chest above/cranial to heart.
- Function: Processes thymocytes and T-cells