Hemoglobin Flashcards
Refers to erythrocytes with normal amount of hemoglobin
Possesses a central pallor which is about 1/3 of its diameter
Normochromic cell
Refers to erythrocytes wherein the central light area of the cell is larger and paler than normal
Hypochromic cell
In a hypochromic cell, what is the result of its MCH and MCHC?
Decreased
Where is hypochromic cell often associated with?
Microcytosis
Red cells which have an increased Hb content and wherein the central light area is smaller than normal
Hyperchromic cell
Variation in Hemoglobin content
Normochromic cell
Hypochromic cell
Hyperchromic cell
Variation in staining property
Polychromasia
Hypochromasia
Hyperchromasia
This condition wherein the red cell are stained with various shades of blue with tinges of pink
Polychromatophilia
Polychromasia
Diffuse basophilia
This is due to the combination of the affinity of hemoglobin to acid stain and the affinity of RNA to the basic dye
Polychromasia
Polychromatophilia
Diffuse basophilia
This variation in staining property is slightly microcytic and indicates reticulocytosis
Polychromasia
Polychromasia grading:
Slight - ?
1+ - ?
2+ - ?
3+ - ?
4+ - ?
1%
3%
5%
10%
>11%
Condition wherein the red cells appear pale
Hypochromasia
What are the 2 possible causes of hypochromasia?
Decrease hemoglobin concentration
Abnormal thinness of the cells: IDA, Sideroblastic anemia, thalassemia
Hypochromasia grading
1+ - ?
2+ - ?
3+ - ?
4+ - ?
Area of central pallor is 1/2 of cell diameter
Area of central pallor is 2/3 of cell diameter
Area of central pallor is 3/4 of cell diameter
Thin rim of hemoglobin
Condition wherein the red cell are deeply stained to abnormal thickness of cells
Hyperchromasia
Causes of hyperchromasia
Macrocytosis
Spherocytosis
Megaloblastic anemia
Variation in size
Normocyte
Macrocyte
Microcyte
Megalocyte
Condition where in the red cells vary in size both macrocytes and microcytes coexist on the same smear
Anisocytosis
What is the diameter of a normocyte?
6-8 um
What are the associated diseases for anisocytosis?
Normal condition acute hemorrhagic anemia
Hemolytic anemia
Aplastic anemia
Cell that is larger than normal greater than 8 um in size round in shape
MCV > 100 FL
Macrocyte
The defect in macrocytes
Abnormal nuclear maturation but normal cytoplasmic maturation
Associated diseases for macrocytes:
Non-megaloblastic anemia myelodysplastic syndrome
Chronic liver disease
Bone marrow failure
Reticulocytosis
Cell which is less than 6 um in size
MCV < 80 FL
Microcyte
Defects of microcytes:
Abnormal cytoplasmic maturation but normal nuclear maturation
Where is microcytosis found in?
Iron deficiency anemia
Thalassemia
Hemolytic anemia
Hb E disease
Inflammation
Chronic post hemorrhagic anemia
Sideroblastic anemia
Large oval-shaped red cell which is 9-12 um
Megalocyte
Defect of megalocyte
Abnormal nuclear maturation but normal cytoplasmic maturation
Where is megalocytosis found in?
Megaloblastic anemia like pernicious anemia
Anemia
Vitamin b12 deficiency anemia
Diphyllobothrium latum
The functional definition if it is a decrease in the oxygen-carrying capacity of the blood.
Anemia
It is defined operationally as a reduction in the hemoglobin content of blood.
Anemia
What can cause anemia?
Insufficient hemoglobin or the hemoglobin impaired function
Abnormal variation in RBC shape
Associated with severe anemia
Poikilocytosis
Small, round, dense RBC with no central pallor
Associated with hereditary spherocytosis, immune hemolytic anemia, extensive burns (schistocytes)
Spherocyte
Elliptical (cigar-shaped), oval (egg-shaped), RBC
Associated with:
Hereditary elliptocytosis/ovalocytosis
Iron deficiency anemia
Thalassemia major
Myelophthisic anemias
Elliptocyte
Ovalocyte
RBC with slit-like area of central pallor
Associated with:
Hereditary stomatocytosis
Rh deficiency syndrome
Acquired stomatocytosis (liver disease, alcoholism)
Artifact
Stomatocyte