Hemodynamic Disorders (Hemostasis) 2

Question 1

initial steps in hemostasis?

most rapid? causes? (2)

the result of this is? how does it help with hemostasis?

Answer 1

Question 2

after vasoconstriction what happens?

the purpose of this?

uses what cells? what needs to happen for the plug to be formed?

Answer 2

Question 3

first step in primary hemostasis will be what?

interaction between? where is each located?

Answer 3

Question 4

what are these?

source of?

located in what cell?

Answer 4

surprise also p-selectin

Question 5

how do wiebel-palade bodies release the vWF?

Answer 5

Question 6

von Willebrand factor released from? in what? allow for?

Answer 6

Question 7

lack of functional vWF called?

lack of GpIb receptor called?

how are they similar?

how different?

Answer 7

Question 8

what is the histological difference in bernard soulier syndrome?

Answer 8

Question 9

second step in primary hemostasis is?

Answer 9

Question 10

platelet activation

after adhesion what happens? (4)

secretion of? (2) what does each cause? secretion initiated by?

Answer 10

Question 11

how does aspirin affect platelet activation?

Answer 11

Question 12

third step in primary hemostasis?

what allows this? what does it interact with?

Answer 12

Question 13

deficiency of the GpIIb-IIIa complex results in?

Answer 13

Question 14

primary hemostasis platelet plug has formed

always recruit what?

Answer 14

Question 15

how do you know if something is wrong with primary hemostasis?

clinically?

laboratory?

Answer 15

Question 16

clinical manifestation of disorders of primary hemostasis

some things you may see?

symptoms depend of what level?

Answer 16

Question 17

bleeding time test?

more modern techniques? looks for?

Answer 17

Question 18

what is cytopenia?

Answer 18

Question 19

what happens after primary hemostasis?

also called? (forming what)

Answer 19

Question 20

coagulation cascade

what are the pathways? why is each named that?

what factors for each one? (in order)

what test for each?

ultimately meet at what point?

whats the final pathway from the meeting point?

Answer 20

Question 21

what are the two tests?

what do you add for each?

Answer 21

Question 22

what factors do you need to know both the factor number and name?

(3)

activated names for 2?

what one if defective leads to disease? which disease?

Answer 22

Question 23

what cofactor is needed for coagulation cascade?

what else is needed for this?

what factors are dependent?

what drug acts at this level? how does it work? which causes?

Answer 23

Question 24

what factor has many functions? names?

what functions does it have? (4)

non activated form name?

Answer 24

II is prothrombin?

Question 25

what happens if you have a defect in hemostasis?

dermatologic manifestations?

more common in?

types (3) special about one?

Answer 25

Question 26

defect in hemostasis

more serious problems?

can be due to? (2)

Answer 26

Question 27

defect in hemostasis

what symptom is more common in factor deficiencies?

common in what disease?

Answer 27

Question 28

diagnosing disorders of secondary hemostasis

factor deficiencies can be detected by?

if APTT?

PT?

combined?

Answer 28

Question 29

fibrinolysis and limitation of clot formation

what 3 things happen?

Answer 29

Question 30

limiting coagulation

(3)

b- how?

f- does what?

p- function? what activates it?

Answer 30

Question 31

endothelium antithrombotic effects

(4)

1.

2. p- what does this?
3. a- what does this? activated? inactivates what?
4. f- activated by?

Answer 31

Question 32

vit K dependent factors?

what also needs vit k? these do what?

Answer 32