Heme/Onc

Question 1

Patients with a protein C deficiency are more likely to develop what condition when taking warfarin?

Answer 1

patients with a protein C deficiency are more likely to develop

warfarin-induced skin necrosis

*Protein C breaks down clotting factors V and VIII

Question 2

how do you treat lead posioning?

Answer 2

Ca-EDTA

Question 3

What are the classic lab findings in

Tumor Lysis Syndrome?

Answer 3

Tumor Lysis syndrome:

hyperkalemia

hyperurecemia

increased creatinine

hyperphosphotemia

hypocalcemia

*keys to this dx in a questions stem include: someone who recently started chemotherapy

Question 4

How do you treat asymptomatic thrombocytopenia?

Answer 4

Treat asymptomatic thrombocytopenia with

OBSERVATION

*treat symptomatic patients (those with a platelet count <30,000) with steroids

Question 5

what is the treatment for non-hemolytic febrile transfustion reaction?

Answer 5

COX inhibitor

Question 6

what is the presentation of an acute hemolytic reaction post transfusion?

Answer 6

Hemolytic reactions

low back/flank pain

low blood pressure

fever

*S/S will occur a few hours after a transfusion. Look for lab findings like increased LDH and a decreased haptoglobin

Question 7

MEN 1

Answer 7

pituitary tumors

parathyroid hyperplasia

pancreatic tumors

Question 8

MEN 2A

Answer 8

parathyroid hyperplasia

medulary thyroid carcinoma

pheochromocytoma

*This is a mutation of the RET gene

Question 9

MEN 2B

Answer 9

mucosal neuromas

marfan syndrome

pheochromocytomas

medullary thyroid carcinoma

*this is a de-novo mutation