Heme/ONc

Question 1

Type of highly aggressive NHL

Answer 1

Burkitt Lymphoma

Question 2

-Increased RBC and total blood volume–>hyperviscosity–>decreased cerebral flow and hyper coagulability -Dx: Hct >54% (men); 51% (women) Tx: Phlebotomy

Answer 2

Polycythemia vera

Question 3

-Dz of middle age men. -Overproduction of myeloid cells -Philadelphia chromosome -Sx: Fever, night sweats, FOUO, sternal tenderness, sig. leukocytosis with L shift

Answer 3

Chronic myeloid Leukemia

Question 4

Malignancy of plasma cells–> messes with hematopoeisis -Bone pain and anemia

Answer 4

Multiple Myeloma

Question 5

-MC leukemia -Progenitor cell malignancy–>uncontrolled proliferation–> replacement normal marrow -Sx: Short duration. Fatigue, fever, LAD, bone pain, bleeding, pancytopenia, auer rods

Answer 5

Acute myelogenous leukemia

Question 6

-B-lymphocytes -Diffuse painless LAD. Drenching night sweats, decrease in weight.

Answer 6

Non-hodgkin lymphoma

Question 7

-MC malignancy in children -Malignancy of progenitor cells -Sx: CNS symptoms; pancytopenia with blasts . Fatigue, (intermittent) fever, bleeding. Petechiae and purport. -Good prognosis

Answer 7

Acute lymphocytic leukemia

Question 8

-Seen in 20’s and again 50’s -Enlargement of lymphoid tissue, spleen and liver. -> EBV assoc. -reed-sternberg cells -Painless LAD (cervical, supraclavicular, mediastinal) (may have pain w. etoh)

Answer 8

Hodgkins lymphoma

Question 9

-Dz of later age. -Malignancy of B lymphocytes -Sx: Leukocytosis, smuge (smear cells) -No currative tx

Answer 9

Chronic Lymphocytic leukemia

Question 10

• Factor 8 deficiency
• X-linked recessive (more men)
• Intrinsic pathway
• Sx: hemarthrosis and bleeding
• Dx: decreased factor 9; prolonged PT.
• Tx: Factor 8

Answer 10

Hemophelia A

Question 11

Inefecctive platlet adhesion (normal aggregation)

• MC hereditary bleeding disorder
• Sx: Mucocutaneous bleeding, easy brusing, petechia
• Dx: vWF, prolonged PTT
• Treatemnt desmopressin

Answer 11

Von Willebrand Dz

Question 12

• MC Acquired coagulopathy
• 2/2 diet, meds

Answer 12

Vit. K deficieincy

Question 13

• Decreased platelts 2/2 antibodies binding platelets
• Asympto to bruising/bleeding

Answer 13

Idiopathic (autoimmune) thrombocytopenia purpura

Question 14

• Genetic underproduction of globin chains–> decreased Hgb
• Alpha thalassemia more common in SE asian/chinese origin
• Beta more common in african, mediterranaian decent
• Microcytic anemia, but normal iron stores

Answer 14

Thalassemia