Heme/onc Flashcards
Renal failure, schistocytes, low platelets after hamburger meat
Hemolytic uremic syndrome
Low platelets, schistocytes, neurologic change, impaired renal function and fever after an infection
Thrombotic thrombocytopenic purpura
Difference between thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
HUS is more associated with renal failure (high creatinine) and TTP manifests with more neurologic symptoms
Three causes of microangiopathic hemolytic anemia (MAHA)
HUS. TTP. DIC
Causes of microcytic anemia
TICS. Thalassemia, iron deficiency, chronic disease, sideroblastic
Cause of hemolytic anemia. X-linked recessive disease with increased RBC sensitivity to oxidative stress.
G6PD deficiency.
Causes of autoimmune RBC destruction
EBV infection , mycoplasma, Chronic lymphocytic leukemia, rheumatoid disease or medications
Hereditary aplastic anemia. Also has cafe au lait spots, short stature, radial/thumb hypoplasia/aplasia
Falconi anemia
Indirect Coombs vs direct Coombs
Indirect detects antibodies to RBCs in serum. Basically add donor RBCs to patients serum
Direct detects RBCs attached to antibodies (sensitize). Basically anti-antibody antibodies
Pink or brown urine. Hemolytic anemia with Photo dermatitis, neuropsychiatric complaints and visceral complaints (colicky abdominal pain and seizures)
Porphyria. 3 types acute intermittent porphyria (AD), erythropoietic purpura (AR), porphyria cutaneous tarda
In a patient presenting with hepatomegaly, cirrhosis, impotence and diabetes
think hereditary hemachromatosis
Correction of Coagulopathy with the in liver failure
Cannot be fixed with vitamin K
Give clotting factors
What is the most common type of thyroid cancer
Papillary carcinoma
Macrocytic Anemia with ovalocytes and neutrophils with reduced segmentation is indicative of
Myelodysplastic syndrome (mds)
What test should you do if Monoclonal gammopathy of unknown significance MGUS is suspected
Do a bone scan for metastases to rule out multiple myeloma
