Heme/Onc

Question 0

Proliferating of mature B cells
CD5+
Smudge cells and WBC>40,00
Most common lymphoid leukemia

Answer 0

CLL

Question 1

Most common cancer of childhood

Good prognosis in children, poorer in adults

Answer 1

ALL

*MAY be associated with t(9,22) BCR-ABL

Question 2

Ayer rods
Affects all ages
Myeloperoxidase+
Relapse is common

Answer 2

AML

Question 3

A form of AML that IS responsive to retinoids

Answer 3

APL

Question 4

WBC>100,000
Low leukocyte esterase 
Mature myeloid cell proliferation
Presents as blast crisis
t(9,22) or BCR-ABL fusion gene

Answer 4

CML

-imatinib or BM Transplant in younger patients

Question 5

Left shift on HbO2 dissoc curve
Splenomegaly
Shortened lifespan
HbH on electrophoresis
Dx?
Tx?

Answer 5

HbH disease (alpha thalassemia missing 3 loci)

Tx: transfusions (same as Beta thal major)

Question 6

Hydrops fetalis or death shortly after birth

• thalassemia type?
• what type of Hb would be found in this patient?

Answer 6

Alpha thalassemia missing all four loci

Hb Bart (binds 02 but cannot release it to tissues)

Question 7

ASx until months after birth
Growth retardation
HSM
High HbA2 and HbF
Dx?
Tx?

Answer 7

Beta thalassemia major
No beta global gene
Tx: transfusions (same as HbH)