Heme

Question 1

Endothelins

Answer 1

Key mediator of vasoconstriciton

Released by endothelial cells

Question 2

Tissue factor

Answer 2

Aka thromboplastin
Expressed in sub-endothelial cells
Major activator of coag cascade
Activates VII to VIIa

Question 3

Unique features of factor VIII

Answer 3

Produced in endothelial cells (vs liver)

Bound to vWF

Question 4

Two blood factor multicomponent complexes

Answer 4

Extrinsic Xase: TF cells, VIIa, TF, X
Intrinsic Xase: Platelets, IXa, VIII, X
*Both require phospholipids and Ca

Question 5

Ca role in clot formation

Answer 5

Required for clot formation, released from platelets

EDTA in blood tubes binds Ca to prevent clotting

Question 6

Factor that crosslinks fibrin

Answer 6

XIII

Requires Ca as cofactor

Question 7

What links coagulation with inflammation?

Answer 7

Kinins (bradykinin)

Required for activation of intrinsic pathway

Question 8

Functions of bradykinin

Answer 8

Vasodilation, increase of vascular permeability, Pain

Question 9

What degrades bradykinin

Answer 9

ACE and C1 inhibitor

Question 10

C1 inhibitor deficiency

Answer 10

aka hereditary angioedema

Bradykinin builds up

Question 11

Prekallikrein deficiency

Answer 11

Rare
XII not activated; prolonged PTT
Asymptomatic

Question 12

What would lack of ATIII lead to?

Answer 12

Hypercoaguable state

Inhibits the serine protease factors

Question 13

Primary fibrinolysis

Answer 13

Overactive plasmin
Increases FDPs but not D-dimer
Can deplete clotting factos -> DIC type scenario

Question 14

Acute phase reactants?

Answer 14

Fibrinogen
Ferritin
CRP