Heme Flashcards
Initial test for anemia
CBC
Accurate test for iron deficiency anemia
BM biopsy for stainable Fe
Treatment for iron deficiency anemia
Oral Fe Sulfate > IM
Accurate test for sideroblastic anemia
Prussian blue for ringed sideroblasts
Accurate test for thalassemia
Hb electrophoresis
Accurate test for B12 deficiency
Ab testing (pernicious)
Treatment for b12 deficiency
1 B12 shot per month
Treatment for folate deficiency
Daily oral folate
Initial test for macrocytic anemia
Peripheral smear (visualize hypersegmented neutrophils)
Treatment for stroke due to SCD
Exchange transfusion
Initial test for SCD
Peripheral smear (Howell jolly bodies)
Accurate test for SCD
Hb electrophoresis
Treatment for Parvo B19 in SCD
IVIG
Accurate test for ParvoB19
PCR
Treatment for SCD that improves mortality
Hydroxyurea + Abx in fever
Accurate test for hereditary spherocytosis
Osmotic fragility test
Treatment for hereditary spherocytosis
Folic acid + splenectomy
Accurate test for AI hemolysis
Coombs (IgG)
Treatment for AI Hemolysis
Glucocorticoids > IVIG > Splenectomy > Rituximab
Accurate test for cold agglutins disease
Cold agglutins titer
Treatment for cold agglutins disease
Stay warm + Rituximab
Initial test for G6PDD
Smear to look for Heinz bodies + bite cells
Accurate test for G6PDD
G6PD level 1-2 months later
Treatment for HUS/TTP
plasmapheresis
Accurate test for PNH
Flow cytometry (decreased CD55/59)
Treatment for PNH
Prednisone > BMT > Eculizumab
Accurate test for aplastic anemia
BM biopsy
Treatment for aplastic anemia
Transfusion + Abx + platelets (acute)BMT (young)ATG + Cyclosporine (old)
Accurate test for PV
JAK2 mutation
Treatment for PV (4)
Phlebotomy/ASA + hydroxyurea + allopurinol + antiHis
Treatment for ET (2)
Hydroxyurea + ASA
Treatment for AML
ATRA
Initial test for leukemia
Blood smear (shows blasts)
Accurate test for leukemia
Flow cytometry
Additional treatment for ALL vs AML
Intrathecal MTX
Treatment for stage 3/4 CLL
Fludarabine + cyclophosphamide + Rituximab
Accurate test for CML
FISH/PCR (for bclABL)
Treatment for CML
Imatinib > BMT
Treatment for leukostatsis rxn
Leukophoresis
Treatment for 5q deletion causing myelodysplastic syndrome
Lenalidonide
Initial test for hairy cell
Smear
Accurate test for hairy cell
Flow cytometry
Treatment for hairy cell
Cladribine or Pentostatin
Initial test for NHL
Excisional biopsy
Treatment for stage 3/4 NHL
Rituximab + CHOP (cyclophosphamide/Adramycin/Vincristine/Prednisone)
Treatment for HL
ABVD (Adramycin/Bleomycin/Vinblastine/Dacarbazine)
Initial test for MM (2)
SPEP (IgG or IgA) + X-ray showing lytic lesions
Accurate test for MM
BM biopsy shows >10% plasma cells
Treatment for Waldenstrom
Plasmapheresis
Treatment for ITP
Steroids > IVIG > splenectomy > Romiplastin
Treatment for vWD
DDAVP > Factor 8
Accurate test for hemophilia
Specific assay for factors 8 and 9
Treatment for hemophilia
DDAVP > Factor 8 + 9
Treatment for DIC
FFP > Cryo
Treatment for HIT
Stop Hep + direct inhibitor + Warfarin
Accurate test for HIT (2)
ELISA (PF4 abs)Serotonin release assay
Accurate test for APS
Russell viper venom
Initial test for APS
PTT elevated which does not correct
Treatment for APS
Hep/Warfarin forever