Hematopoietic Tissue Flashcards
stages of erythropoiesis
proerythroblast basophilic erythroblast polychromatophilic erythroblast orthochromatophilic erythroblast reticulocyte mature erythrocyte
Prominent features: Proerythroblast
3 nucleoli
Prominent features: Basophilic erythroblast
Intense basophilic cytoplasm
Prominent features: Polychromatophilic erythroblast
Less basophilic cytoplasm
Checkerboard pattern in nucleus
Prominent features: Orthrochromatophilic erythroblast
Dense nucleus, off-center
Eosinophilic cytoplasm
Prominent features: Reticulocyte
No nucleus, rRNA mesh (specific stain methylene blue)
Prominent features: Mature erythrocyte
No nucleus, eosinophilic cytoplasm
When switch from blue to red, mitotic to not-mitotic?
poly –> ortho
Stages of granulopoiesis
myeloblast –> promyelocyte –>
myelocyte –> metamyelocyte –> band cell –>
eosinophil, neutrophil, basophil
hallmark myeloblast vs promyeloblast
promyeloblasts have granules
at what stage granulopoiesis start showing characteristics of cell type
myelocyte
B lymphocytes develop in
bone marrow and spleen
T lymphocytes develop in
thymus
stages lymphopoiesis
MLP –> lymphblast –> prolymphoblast –> b-lymphocyte, t-lymphocyte, NK cells (cannot tell apart stages)
Monopoiesis stages
CMP –> monoblast –> promonocyte –> monocyte
yolk sac
hematopoiesis
Liver
erythropoiesis dominates until mid-fetal life
spleen
hematopoiesis at 3rd month
erythropoiesis and granulopoeisis between 3rd and 5th fetal months - 7th-8th
lymphopoiesis continues throughout life
bone marrow
begins in 5th fetal month
thymus
lymphopoiesis only
