Hematopoietic Growth Factors Flashcards
1
Q
Nutritional growth factors
A
- Ferrous Iron
- Folic Acid
- Hydroxocobalamin (b12)
2
Q
Hormonal Growth factors
A
- Epoeitin alpha, Darbopoetin
- G-CSF
- GM-CSF
3
Q
Who is must susceptible to anemia?
A
*women-childbearing age
4
Q
What type of anemia does B12 cause?
A
Megaloblastic
Not macrocytic?
5
Q
Erythropoiesis
required nutrients
A
- iron
- folic acid
- Hydroxycobalamine
6
Q
Erythropoiesis
Required growth factors
A
G-CSF
GM-CSF
Epoetin
7
Q
Most common anemia?
A
Iron deficiency
8
Q
Non-heme iron in non-meat foods must be
A
Reduced to ferrous iron (ascorbate/Vit C + HCl helps)
9
Q
Iron
Absorption
A
- duodeunum + proximal jejunum
* increases w/ low stores
10
Q
Iron
Elimination
A
- no excretion MOA
- regulate - change absorption/storage
- body iron stores high = stored
- body iron stores low = transported ot bone marrow for Hb production
11
Q
Apoferritin
A
- Free iron low = synthesis inhibited, iron to transferrin
* Free iron high = synthesis stimulated, iron to ferritin (no toxicity)
12
Q
Iron toxicity
(Kills gut lining)
Acute Tx
A
Deferoxamine
Bowel irrigation
13
Q
Iron toxicity
(Heart, liver, pancreas, other)
Chronic
A
Deferoxamine
Deferasirox - oral
Phlebotamy
14
Q
Iron salts
A
- 1/4 absorbed
* cheap
15
Q
Iron salts
S.E.
A
- Epigastric distress
* Abdominal cramps
