Anticholinergic Flashcards
Direct ags
Ach Carbachol Bethanechol Nicotine Varenicline
Indirect-Acting ags
Neostigmine (t1/2 short)
Physostigmine
Donepezil
Sarin (t1/2 long)
Ach Release Blocker
Botulinium toxin
Muscarinic blocker
Atropine
Ipratropium
Nicotinic Blockers
Trimethaphan
Vecuronium
Succinylcholine
AchE reactivator
Pralidoxime
Muscarinic ags
Uses
Overcoming postop paralytic ileus = from atropine, opioids
Muscarinic ags
SE
HypoTN
Diarrhea
Vomiting
Bronchial constriction
Muscarinic Ags
Contraindication
Asthma Heart condition Peptic ulcer GI Urinary Tract Obstruction Hyperthyroidism
Glaucoma = Primary open angle
Tx
Carbachol
Constrict iris/ciliary muscle
Preanesthetic meds
Atropine
Reduce secretions
Need bronchodilation in COPD
Ipratroprium
Muscarinic Antags
Neuronal nicotinic receptor - where?
Post gangionic sympa + parasympa
Nicotinic Receptors
Postsynaptic function
- depols
* excitation of neurons/muscle
Nicotinic Receptors
Presynaptic
Enhance release of NTs in CNS