Hematopoiesis Flashcards
Self-renewing
able to create another undifferentiated stem cell (stem cells have self-renewing ability, but not blast cells)
Differentiation
cells shrink, lose nucleoli, granules appear, nucleus changes shape
Which cells differentiate and self-renew
colony forming unites (progenitor cells that differentiate into a limited number of cell types) can replicate and produce blast cells
Draw schematic of changes in properties of a hemopoietic cell during differentiation (potentiality, mitotic activity, self-renewing capacity, influence of growth factors, differentiated functional activity, morph characteristics)
PIC
erythropoietin
Growth factor; produced by renal cells, stim RBC development
GM-CSF
growth factorl produced by lymphocytes, endothelium & fibroblasts; stim granulocyte and macrophage development
G-CSF
growth factor; produced by macrophages, endothelium and fibroblasts; stim granulocyte development
IL-3
growth factor; produced by T-lymphocytes; stim production of all myeloid cells
Thrombopoeitin
growth factor; produced by liver and kidney; stim production of platelets.
where does blood cell development occur in the early fetus?
yolk sac
where does blood cell development occur in the mid-fetal months?
liver and spleen
where does blood cell development occur in the late fetal months?
bone marrow
where does blood cell development occur in an adult?
bone marrow/medullary (mostly in vertebrae, ribs, pelvis, sternum), but liver and spleen can resume production if necessary (extramedullary)
Red marrow characteristics
active marrow, relatively less fat and more cells making blood cells
yellow marrow characteristics
inactive marrow, lots of fat; has the ability to convert back to red marrow if necessary
