Hematopoiesis

Question 1

Continuous, regulated process of blood cell
production

Answer 1

Hematopoiesis

Question 2

What are the stages of hematopoiesis?

Answer 2

Mesoblastic, Hepatic, Medullary/Myeloid Stage

Question 3

Where is the site of hematopoiesis in the mesoblastic stage?

Answer 3

Yolk sac of the human embryo

Question 4

what is the day of the development of mesoblastic stage?

Answer 4

19th day

Question 5

what kind of cells form in the mesoblastic stage?

Answer 5

primitive nucleated erythroblasts

Question 6

what does the primitive erythroblast form? list the 3 forms

Answer 6

Hemoglobin
Gower 1
Gower 2
Portland

Question 7

Gower 1 - (? and ?)

Answer 7

2 Zeta and 2 Epsilon

Question 8

Gower 2 - (? and ?)

Answer 8

2 alpha and 2 epsilon

Question 9

Portland (? and ?)

Answer 9

2 Zeta and 2 Gamma

Question 10

Gower 1
Gower 2
Portland
are not detectable after what month?

Answer 10

3rd month of gestation

Question 11

what is the site of hematopoiesis of hepatic stage? and what week?

Answer 11

Fetal Liver and 5th to 7th week of gestation

Question 12

___________ disappear during this stage

Answer 12

Hematopoiesis in the AGM region and the yolk sac

Question 13

what organs contribute to hepatic stage?

Answer 13

spleen, kidney, thymus, and lymph nodes

Question 14

first fully developed organ in the fetus

Answer 14

thymus

Question 15

Hb F (? and ? ) and when is it produced?

Answer 15

2 alpha and 2 gamma
4th month of gestation

Question 16

production of hematopoietic cells in bone marrow and starts in bone marrow

Answer 16

medullary

Question 17

production of hematopoietic cells in the liver and spleen

Answer 17

extramedullary

Question 18

myeloid cells being
produced outside the marrow

Answer 18

myeloid metaplasia

Question 19

what is the site of hematopoiesis of the myeloid stage?

Answer 19

bone marrow

Question 20

by the end of what week does the bone marrow becomes the primary site of hematopoiesis?

Answer 20

24th week

Question 21

what organ began to slowly diminish in the last trimester ?

Answer 21

Liver

Question 22

Hb-A1 (? and ?)
Hb-A2 (? and ?

Answer 22

2 alpha and 2 beta
2 alpha and 2 delta

Question 23

transport oxygen?

Answer 23

iron

Question 24

needed for goblin chain synthesis?

Answer 24

amino acids

Question 25

dna replication and cell division

Answer 25

folic acids and vitamin b12

Question 26

what percent of bone marrow is active in new born?

Answer 26

80% -90%

Question 27

what percent of bone marrow is active in young adult?

Answer 27

60%

Question 28

what percent of bone marrow is active in older adult?

Answer 28

40%

Question 29

 Aka pluripotential or multipotential cells o Retain the ability to differentiate into any cell lines

Answer 29

Stem cells

Question 30

Major site of blood cell production in 2nd trimester (hepatic phase)

Answer 30

Liver

Question 31

 Sequesters membrane-damaged RBCs and removes them from the circulation  Largest lymphoid organ in the body

Answer 31

Spleen

Question 32

 Bean-shaped structures  Superficial or deep  Lymph  Cortex, paracortex, medulla  Site of lymphocyte proliferation, initiation of specific immune response, filter particulate matter-debrisbacteria

Answer 32

Lymph nodes

Question 33

In adults, T cell progenitors migrate to the ______ from the bone marrow for further maturation

Answer 33

thymus

Question 34

: 30-70% hematopoietic cells

Answer 34

Normocellular

Question 35

<30% hematopoietic cells

Answer 35

Hypocellular

Question 36

: >70% hematopoietic cells

Answer 36

Hypercellular

Question 37

few or no hematopoietic cells

Answer 37

Aplastic

Question 38

Detects myelocytic cells by staining cytoplasmic granular contents

Answer 38

Myeloperoxidase (MPO)

Question 39

Detects myelocytic cells by staining cytoplasmic granular contents

Answer 39

Sudan black B (SBB)

Question 40

Detects lymphocytic cells and certain abnormal erythrocytic cells by staining of cytoplasmic glycogen

Answer 40

Periodic acidSchiff (P

Question 41

: largest bone marrow cell

Answer 41

Megakaryocyte

Question 42

most common cell in bone marrow

Answer 42

metamyelocyte

Question 43

nonspecific alpha naphthyl acetate

Answer 43

macrophages

Question 44

) chloroacetate esterase

Answer 44

Mast cells

Question 45

synthesized new bone matrix; water bug/comet appearance

Answer 45

osteoblasts

Question 46

large and multinucleated, bone-resorbing cells

Answer 46

osteoclasts

Question 47

 Unipotential stem cells  Differentiate into only one cell line

Answer 47

Progenitor

Question 48

 Blast forms  Comprise the third marrow compartment

Answer 48

Precursor cells

Question 49

 Size: 12 to 20 um  Nucleus: round to slightly oval o Nucleoli: 1 to 2 o Chromatin: fine  Cytoplasm: dark blue; may have prominent golgi  N:C Ratio: 8:1

Answer 49

Rubriblast

Question 50

Globin production begins, protein and enzymes for iron uptake and protoporphyrin synthesis produced

Answer 50

Rubriblast

Question 51

 Size: 10 to 15 um  Nucleus: round to slightly oval o Nucleoli: 0 to 1 o Chromatin: slightly condensed  Cytoplasm: deeper, richer blue than pronormoblast – “basophilic”  N:C Ratio: 6:1  Detectable hemoglobin synthesis occurs

Answer 51

Prorubricyte

Question 52

 Last stage capable of mitosis

Answer 52

Rubicyte