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HEMA LEC > Hematopoiesis > Flashcards

Hematopoiesis Flashcards

1
Q

Continuous, regulated process of blood cell
production

A

Hematopoiesis

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2
Q

What are the stages of hematopoiesis?

A

Mesoblastic, Hepatic, Medullary/Myeloid Stage

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3
Q

Where is the site of hematopoiesis in the mesoblastic stage?

A

Yolk sac of the human embryo

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4
Q

what is the day of the development of mesoblastic stage?

A

19th day

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5
Q

what kind of cells form in the mesoblastic stage?

A

primitive nucleated erythroblasts

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6
Q

what does the primitive erythroblast form? list the 3 forms

A

Hemoglobin
Gower 1
Gower 2
Portland

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7
Q

Gower 1 - (? and ?)

A

2 Zeta and 2 Epsilon

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8
Q

Gower 2 - (? and ?)

A

2 alpha and 2 epsilon

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9
Q

Portland (? and ?)

A

2 Zeta and 2 Gamma

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10
Q

Gower 1
Gower 2
Portland
are not detectable after what month?

A

3rd month of gestation

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11
Q

what is the site of hematopoiesis of hepatic stage? and what week?

A

Fetal Liver and 5th to 7th week of gestation

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12
Q

___________ disappear during this stage

A

Hematopoiesis in the AGM region and the yolk sac

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13
Q

what organs contribute to hepatic stage?

A

spleen, kidney, thymus, and lymph nodes

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14
Q

first fully developed organ in the fetus

A

thymus

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15
Q

Hb F (? and ? ) and when is it produced?

A

2 alpha and 2 gamma
4th month of gestation

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16
Q

production of hematopoietic cells in bone marrow and starts in bone marrow

A

medullary

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17
Q

production of hematopoietic cells in the liver and spleen

A

extramedullary

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18
Q

myeloid cells being
produced outside the marrow

A

myeloid metaplasia

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19
Q

what is the site of hematopoiesis of the myeloid stage?

A

bone marrow

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20
Q

by the end of what week does the bone marrow becomes the primary site of hematopoiesis?

A

24th week

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21
Q

what organ began to slowly diminish in the last trimester ?

A

Liver

22
Q

Hb-A1 (? and ?)
Hb-A2 (? and ?

A

2 alpha and 2 beta
2 alpha and 2 delta

23
Q

transport oxygen?

A

iron

24
Q

needed for goblin chain synthesis?

A

amino acids

25
Q

dna replication and cell division

A

folic acids and vitamin b12

26
Q

what percent of bone marrow is active in new born?

A

80% -90%

27
Q

what percent of bone marrow is active in young adult?

A

60%

28
Q

what percent of bone marrow is active in older adult?

A

40%

29
Q

 Aka pluripotential or multipotential cells
o Retain the ability to differentiate into any cell
lines

A

Stem cells

30
Q

Major site of blood cell production in 2nd trimester
(hepatic phase)

A

Liver

31
Q

 Sequesters membrane-damaged RBCs and removes
them from the circulation
 Largest lymphoid organ in the body

A

Spleen

32
Q

 Bean-shaped structures
 Superficial or deep
 Lymph
 Cortex, paracortex, medulla
 Site of lymphocyte proliferation, initiation of specific
immune response, filter particulate matter-debrisbacteria

A

Lymph nodes

33
Q

In adults, T cell progenitors migrate to the ______
from the bone marrow for further maturation

A

thymus

34
Q

: 30-70% hematopoietic cells

A

Normocellular

35
Q

<30% hematopoietic cells

A

Hypocellular

36
Q

: >70% hematopoietic cells

A

Hypercellular

37
Q

few or no hematopoietic cells

A

Aplastic

38
Q

Detects myelocytic cells by staining
cytoplasmic granular contents

A

Myeloperoxidase
(MPO)

39
Q

Detects myelocytic cells by staining
cytoplasmic granular contents

A

Sudan black B
(SBB)

40
Q

Detects lymphocytic cells and certain
abnormal erythrocytic cells by staining of
cytoplasmic glycogen

A

Periodic acidSchiff (P

41
Q

: largest bone marrow cell

A

Megakaryocyte

42
Q

most common cell in bone marrow

A

metamyelocyte

43
Q

nonspecific alpha naphthyl acetate

A

macrophages

44
Q

) chloroacetate esterase

A

Mast cells

45
Q

synthesized new bone matrix; water
bug/comet appearance

A

osteoblasts

46
Q

large and multinucleated, bone-resorbing
cells

A

osteoclasts

47
Q

 Unipotential stem cells
 Differentiate into only one cell line

A

Progenitor

48
Q

 Blast forms
 Comprise the third marrow compartment

A

Precursor cells

49
Q

 Size: 12 to 20 um
 Nucleus: round to slightly oval
o Nucleoli: 1 to 2
o Chromatin: fine
 Cytoplasm: dark blue; may have prominent golgi
 N:C Ratio: 8:1

A

Rubriblast

50
Q

Globin production begins, protein and enzymes for
iron uptake and protoporphyrin synthesis produced

A

Rubriblast

51
Q

 Size: 10 to 15 um
 Nucleus: round to slightly oval
o Nucleoli: 0 to 1
o Chromatin: slightly condensed
 Cytoplasm: deeper, richer blue than pronormoblast –
“basophilic”
 N:C Ratio: 6:1
 Detectable hemoglobin synthesis occurs

A

Prorubricyte

52
Q

 Last stage capable of mitosis

A

Rubicyte

HEMA LEC (4 decks)

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