Hematopoiesis

Question 1

TRUE OR FALSE:

Yellow marrow is composed primarily of adipocytes, with undifferentiated mesenchymal cells and macrophages.

Answer 1

TRUE

-Page 78 Rodak’s

Question 2

The process of replacing the active marrow (yellow marrow) during development is called ____.

a. regression
b. retrogression
c. retrogradation
d. NOTA

Answer 2

B. retrogression

Rodak’s page 78

Question 3

All are secondary lymphoid organs except:

a. Spleen
b. Lymph nodes
c. Thymus
d. GALT
e. NOTA

Answer 3

C. Thymus

-Thymus is a primary lymphoid organ, responsible for T cell production.

Question 4

Mesoblastic phase is also termed as

a. Yolk sac phase
b. Blast phase
c. Mesenchymal phase
d. Two of the above

Answer 4

d. Two of the above

- Yolk sac/Mesenchymal phase

Question 5

TRUE OR FALSE:
Yolk sac hematopoiesis differs from other hematopoiesis that occurs later in the fetus and the adult in that it occurs intravascularly, or within developing blood cells

Answer 5

TRUE
-Hepatic phase occurs extravascularly, with the liver remaining the major site and Medullary phase occurs in the medulla of the BM
(Rodak’s Page 77)

Question 6

It is a continuous, regulated process of blood cell production that includes cell renewal, proliferation, differentiation and maturation.

a. Erythropoiesis
b. Granulopoiesis
c. Hematopoiesis
d. Hematemesis

Answer 6

C. Hematopoiesis

Question 7

A 23-year old female is on it’s 12th week of gestation when she had her check-up in an ob-gyn clinic. The results of her laboratory tests show a decrease in potassium, protein, and sodium. What organ becomes hematopoietically active during 12th week or 3rd month of gestation?

a. Liver
b. Yolk sac
c. Bone marrow
d. NOTA

Answer 7

A. Liver

- Yolk sac discontinues its role and Fetal liver becomes active.

Question 8

Embryonic forms of hemoglobin differs in terms of their:

a. bonds
b. globin chains
c. charges
d. NOTA

Answer 8

B. globin chains

Question 9

Gower I contains which polypeptide chains?

a. 2 zeta chains, 2 gamma chains
b. 2 zeta chains, 2 epsilon chains
c. 2 zeta chains, 1 epsilon chain
d. 2 zeta chains, 1 gamma chain

Answer 9

b. 2 zeta chains, 2 epsilon chains

Question 10

Portland contains which polypeptide chains?

a. 2 zeta chains, 2 gamma chains
b. 2 zeta chains, 2 epsilon chains
c. 2 zeta chains, 1 epsilon chain
d. 2 zeta chains, 1 gamma chain

Answer 10

a. 2 zeta chains, 2 gamma chains

Question 11

All are fetal forms of hemoglobin except:

a. Portland
b. Hb A
c. Hb F
d. Hb A2

Answer 11

A. Portland

-Portland is an embryonic form of hgb

Question 12

The most predominant form of hemoglobin during the hepatic phase

a. Portland
b. Hb A
c. Hb F
d. Hb A2

Answer 12

c. Hb F

- Fetal hemoglobin

Question 13

Which organ is the site of sequestration of platelets?

a. kidney
b. liver
c. spleen
d. NOTA

Answer 13

C. Spleen

-Rodak’s page 82

Question 14

Which cytokine stimulates proliferation of erythroid progenitors and prevents apoptosis of CFU-E?

a. G-CSF
b. EPO
c. GM- CSF
d. NOTA

Answer 14

B. EPO

-Rodak’s Table 7.2 page 90

Question 15

When a patient has severe anemia and the bone marrow is unable to effectively produce red blood cells to meet the increased demand, one of the body’s responses is:

a. Extramedullary hematopoiesis in the liver and spleen
b. Decreased production of erythropoietin by the kidney
c. Increased apoptosis of erythrocyte progenitor cells
d. Increase the proportion of yellow marrow in the long bones

Answer 15

A. Extramedullary hematopoiesis in the liver and spleen
-The liver can maintain hematopoietic stem and progenitor cells to produce various blood cells (extramedullary hematopoiesis) as a response to infectious agents or in pathologic myelofibrosis of the bone marrow.
Rodak’s page 80