Erythrocyte Production & Destruction Flashcards
All are key features of erythropoiesis except:
a. As hemoglobin develops, the cytoplasm becomes more magenta
b. As cell matures, the nuclear chromatin pattern becomes coarser, clumped, and condensed
c. The overall diameter of the cell decreases
d. The N:C ratio increases
D. The N:C ratio increases
-As cell matures, the diameter of the nucleus decreases more rapidly than does the size of the cell. As a result, the N:C ratio also decreases
Principal stimulus for EPO production
a. pancytopenia
b. hypoxia
c. anemia
d. NOTA
B. Hypoxia
-Hypoxia is detected by the peritubular cells of the kidney which produces EPO, the major stimulatory cytokine for RBCs.
Major pathway where 90% of aged RBCs are destructed
a. Intravascular pathway
b. Mechanical pathway
c. Macrophage-mediated pathway
d. NOTA
C. Macrophage-mediated pathway
-also termed as Extravascular pathway
What percentage of red cells is destroyed and replaced daily in a normal adult?
a. 1%
b. 5%
c. 3%
d. NOTA
A. 1%
-Approximately 1% of the RBC leaves the circulation each day and are broken down by the mononuclear phagocytic system (MPS)
Last stage of Mitosis
a. Rubricyte
b. Prorubricyte
c. Metarubricyte
d. NOTA
A. Rubricyte
/Polychromatic normoblast
The earliest recognizable stage in erythropoiesis:
a. Rubriblast
b. Prorubricyte
c. Rubricyte
d. NOTA
A. Rubriblast
/Pronormoblast
What erythrocyte precursor is described as follows:
Nucleus is small, pyknotic and eccentric. The cytoplasm appears pink/pink-orange and has a N:C ratio of 1:2
a. Polychromatic normoblast
b. Orthochromic normoblast
c. Reticulocyte
d. Two of the above
b. Orthochromic normoblast
/Metarubricyte
Start of Hgb synthesis
a. Rubriblast
b. Prorubricyte
c. Rubricyte
d. NOTA
C. Rubricyte
/Polychromatic normoblast
In this stage, Globin production begins. Proteins and enzymes necessary for iron uptake and protoporphyrin synthesis are produced.
a. Rubriblast
b. Prorubricyte
c. Rubricyte
d. NOTA
A. Rubriblast
/Pronormoblast
It is a morphologic feature used to identify and stage red blood cell and white blood cell precursors
a. Cytoplasm
b. Cell diameter
c. Nuclear chromatin pattern
d. N:C ratio
D. N:C ratio
-this ratio is a visual estimate to what area of the cell is occupied by the nucleus compared with the cytoplasm. It is used to identify and stage red blood cell and white blood cell precursors
The proportion of nucleus shrinks as the cell matures.
The cytoplasm decreases proportionately.
a. 1st statement is true, 2nd statement is false
b. 2nd statement is true, 1st statement is false
c. All are true
d. All are false
a. 1st statement is true, 2nd statement is false
- The cytoplasm increases proportionately
TRUE OR FALSE:
The overall cell diameter or rbc grows smaller as it matures, hence the N:C ratio decreases.
True
How many days will it take for the production of reticulocytes from pronormoblast?
a. 3-5 days
b. 4-6 days
c. 1-3 days
d. NOTA
A. 3-5 days
TRUE OR FALSE:
Matured RBC is not capable of Hgb synthesis
True
-because it does not contain mitochondira
It is the name given to the collection of all stages of erythrocytes throughout the body
a. Erythrodynamics
b. Erythron
c. Erythrokinetics
d. NOTA
B. Erythron
