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Pathophys Semester 2 > Hematopathology- Erin Wright > Flashcards

Hematopathology- Erin Wright Flashcards

1
Q

heme=

A

blood

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2
Q

penia=

A

deficiency

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3
Q

myelo=

A

bone marrow

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4
Q

What are the types of CBCs one can order?

A
  • CBC with no differential
  • CBC with automatic differential
  • CBC with manual differential.
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5
Q

How does a CBC w/ automatic diff. differ from a CBC w/ manual diff.?

A
  • Automatic diff: A computer is reading it and giving you a report
  • Manual diff: A lab tech is manually counting the cells.
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6
Q

What is the most important lab when discussing and evaluating a disease of hematologic nature?

A

CBC

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7
Q

What is a WBC count?

A

total # of leukocytes

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8
Q

What are leukocytes?

A

WBCs:

  • Lymphocytes
  • Monocytes
  • Eosinophils
  • Basophils
  • Neutrophils
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9
Q

What is the numeric relationship between hematocrit and hemoglobin?

A

Hematocrit is 3x the value of hemoglobin.

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10
Q

CBC: Why are absolute values more helpful than percentage values?

A

A percentage will tell you the relative nature of the amount of a leukocyte. An absolute count tells you precisely how many of a leukocyte type is present.

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11
Q

What can fluid gathered from a bone marrow aspiration do for you?

A
  • Molecular genetics

- Flow cytometry

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12
Q

What information can you gather from a bone marrow biopsy?

A
  • Cell constitution

- Represents all cells

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13
Q

When comparing a bone marrow aspiration with a biopsy, which provides you with more information?

A

bone marrow biopsy

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14
Q

Define hematopoiesis

A

blood cell formation

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15
Q

Define thrombopoiesis

A

production of platelets

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16
Q

Define erythropoiesis

A

production of RBCs

17
Q

Define leukopoiesis

A

production of white cells

18
Q

Hematopoiesis: What is the most basic stem cell?

A

Multipotent hematopoietic stem cell (hemocytoblast)

19
Q

Hematopoiesis: Hemocytoblasts develop into one of two stem cells?

A

Myeloid and lymphoid stem cells

20
Q

Hematopoiesis: Myeloid stem cells end up producing what type of cells?

A
  • Platelets
  • Erythrocyte
  • Basophil
  • Neutrophil
  • Eosinophil
  • Monocyte.
21
Q

Hematopoiesis: Myeloid stem pants evolve into what cells?

A
  • Megakaryoblast
  • Proerythroblast
  • Myeloblast
  • Monoblast
22
Q

Hematopoiesis: Pathway between a myeloid stem cell and a platelet?

A
  • > Megakaryoblast
  • -> Megakaryocyte
  • -> Platelet
23
Q

Hematopoiesis: Pathway between a myeloid stem cell and an erythrocyte?

A
  • -> Proerythroblast
  • -> Reticulocyte
  • -> Erythrocyte
24
Q

Hematopoiesis: Pathway between a myeloid stem cell and a monocyte?

A
  • -> Monoblast

- -> Monocyte

25
Q

Hematopoiesis: A myelobast can develop into what types of leukocytes?

A
  • Basophil
  • Neutrophil
  • Eosinophil
26
Q

Hematopoiesis: Lymphoid stem cells develop into what final cells?

A
  • Natural killer cell (large granular lymphocyte)
  • T lymphocytes
  • B lymphocytes
27
Q

Hematopoiesis: Describe the pathway between a Lymphoid stem cell and a NKC.

A

Lymphoid stem cell

  • -> lymphoblast
  • -> NKC
28
Q

Hematopoiesis: What is another name for an NKC?

A

Large granular lymphocyte. (these questions are NOT on her test).

29
Q

Hematopoiesis: A lymphoblast can develop into a small lymphocyte which can then evolve into what cells?

A
  • T lymphocytes

- B lymphocytes

30
Q

Thrombopoiesis: Where is thrombopoietin generated?

A

kidneys and liver

31
Q

Thrombopiesis: Where are old platelets destroyed?

A

spleen and liver

32
Q

Erythropoesis: When does a reticulocyte become a mature erythrocyte?

A
  • Reticulocyte gets released into circulation

- After 1-2 days becomes a mature erythrocyte

33
Q

Erythropoesis: What does a reticulocyte need to become an erythrocyte?

A
  • Vitamin B12

- Vitamin B9 (folic acid)

Pathophys Semester 2 (12 decks)

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