Hematolymphatic

Question 1

What is hematopoiesis?

Answer 1

Production of blood cells

Question 2

What is erythopoiesis?

Answer 2

Production of red blood cells (RBCs)

Question 3

What is granulopoiesis?

Answer 3

Production of neutrophils, eosinophils, and basophils.

Question 4

What is thrombopoiesis?

Answer 4

Production of platelets.

Question 5

What is the primary site of hematopoiesis in adults?

Answer 5

Bone marrow

Question 6

What is the most common site of extramedullary hematopoiesis?

Answer 6

Spleen

Question 7

What is extramedullary hematopoiesis (EMH)?

Answer 7

Blood cell production outside of the bone marrow.

Question 8

How does bone marrow composition change with age?

Answer 8

Shift from hematopoietic tissue (red marrow) to adipose tissue (yellow marrow)

Question 9

What does the colour of bone marrow depend on?

Answer 9

The color of the bone marrow is dependent on the ratio between hematopoietic tissue (red) and adipose tissue (yellow).

Question 10

Hematopoietic tissue is highly…

Answer 10

proliferative

Question 11

All blood cells are derived from…

Answer 11

a common pluripotent hematopoietic stem cell.

Question 12

What is the earliest commitment a pluripotent stem cell makes in the process of hematopoiesis?

Answer 12

The earliest commitment is to either the lymphoid or myeloid line.

Question 13

How many lineages arise from the myeloid stem cell?

Answer 13

3

Question 14

Hematopoietic stem cells are capable of ____ and can repopulate the ____.

Answer 14

self-renewal, bone marrow

Question 15

What are the sequential divisions that hematopoetic stem cells undergo?

Answer 15

Stem cell → committed cells → maturing cells → mature cells.

Question 16

Arrange the following cells in order of their lifespan (short to long):
- Platelets
- Erythrocytes
- Neutrophils
- Lymphocytes

Answer 16

Lymphocytes < neutrophils < platelets < erythrocytes

Question 17

What controls hematopoesis?

Answer 17

Control of hematopoiesis is under local and systemic control with many redundancies = Response is rapid and predictable.

Question 18

In healthy animals, production and turnover of blood cells are…

Answer 18

balanced

Question 19

Increased numbers of immature neutrophils in circulation is known as a…

Answer 19

“left shift”

Question 20

What is a left shift?

Answer 20

Increased numbers of immature neutrophils in circulation.

Question 21

What type of anemia is caused by bone marrow injury?

Answer 21

Non-regenerative anemia

Question 22

What type of anemia is caused by insults to peripheral blood?

Answer 22

Regenerative anemia

Question 23

What will happen if pluripotent stem cells are damaged?

Answer 23

Multiple cell lines affected (pancytopenia)

Question 24

What is pancytopenia?

Answer 24

Reduced numbers of all blood cells.

Question 25

What will happen if differentiated stem cells are damaged?

Answer 25

One cell line is affected

Question 26

What is cytopenia?

Answer 26

Deficiency in blood cells

Question 27

What are terms for increased concentrations of blood cells?

Answer 27

“cytosis” and “philia”

Question 28

What does increased cellularity of bone marrow look like?

Answer 28

More red marrow.