Hematology Neoplasms

Question 1

BCR-ABL mutation is diagnostic of which malignancy?
What are the Chromosomes involved in this mutation?

Answer 1

Chronic myeloid leukemia
t(9:22)

Question 2

Tx of chronic myeloid leukemia

Answer 2

Imatinib (gleevec) :TKI

Question 3

Genetic mutation of which enzyme is most associated with polycythemia vera

Answer 3

JAK2

Question 4

Essential thrombocythemia and primary myelofibrosis are associated with which genetic mutations?

Answer 4

JAK2
CALR

Question 5

Management of essential thrombocythemia in a patient >60 yrs with platelets>1500

Answer 5

Aspirin and hydroxyurea

Question 6

Management of essential thrombocythemia in a <60 yrs old patient

Answer 6

Aspirin

Question 7

Main management of polycythemia vera

Answer 7

Venesection (aim HCT <0.45)

Question 8

A biopsy is taken from rectal mucosa ana shows apple green birefringence under polarized light when stained with congo red staining.
What is the most likely diagnosis?

Answer 8

Amyloidosis (associated with multiple myeloma)

Question 9

Urinary analysis of a Patient with bony pain shows Bence Jones proteins,
What is the probable diagnosis?

Answer 9

Multiple myeloma

Question 10

Mention 3 tranlocation mutations associated with myeloma

Answer 10

t(4, 14) :FGFR3/MMSET
t(11,14) :CYCLIN D1
t(6,14) :Cyclin D3

Question 11

Burkitt’s Lymphoma arises due to a mutation in C-myc gene.
What are the Chromosomes involved in this C-myc translocation?

Answer 11

8,14

Question 12

Gene involved in diffuse large Bcell lymphoma

Answer 12

BCL-6 in Chromosome 3q27

Question 13

PML-RARA gene mutation is evident in wh8ch malignancy

Answer 13

Acute promyelocytic leukemia