Antiplatelets And Anticoagulant Therapy Flashcards

1
Q

MOA OF heparin

A

Accelerates Antithrombin inhibition of factor Xa and IIa (thrombin)

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2
Q

Test used for monitoring of unfractionated heparin

A

APTT

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3
Q

Test used fpr monitoring of low molecular weigjt heparin

A

Anti Xa assay

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4
Q

Tx of overdose of unfractionated heparin

A

Protamine sulfate

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5
Q

Maximum effect of warfarin is attained after ….. Days

A

3 to 5 days

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6
Q

T or F
Warfarin crosses placenta and is teratogenic

A

True

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7
Q

Test used to monitor warfarin

A

PT

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8
Q

A patient has been taking warfarin for a while now, his INR is from 6-8 and there is minor bleeding
What is the management?

A

Stop warfarin for 24-48 hours.
• Recheck INR
• re-introduce drug at lower dosage and retest in 2-7 day

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9
Q

A patient is taking warfarin for a while now, his INR is >8 with minor bleeding
What is the management?

A

Stop warfarin for 48 hours and retest on third day before
restarting warfarin at lower dose.
• Consider Vitamin K

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10
Q

IV vitamin k takes…… Hrs to reach its therapeutic effect

A

6 hrs

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11
Q

A patient is taking warfarin for a while now, his INR is very high (life threatening, sight threatening, limb threatening)
What is the management?

A

Stop warfarin for 48 hours and retest on third day before
restarting warfarin at lower dose.
• Consider Vitamin K 2.5mg orally (Menadiol) or 1-2mg by slow
iv injection (Phytomenadione)

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12
Q

Tx of choice in Phlegmasia cerulea dolens

A

Catheter directed thrombolysis

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13
Q

Mention a direct thrombin inhibitor

A

Dabigatran

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14
Q

Mention 2 factor Xa inhibitors

A

Direct: Rivaroxaban, apixaban
Indirect: fondaparinux

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15
Q

Mention an ADP inhibitor (antiplatelets)

A

Clopidogrel

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16
Q

In heparin induced thrombocythemia, what is the patholpgy?

A

IgG against Heparin/PF4 complex detected after 5 days in serology

17
Q

MOA of warfarin

A

Vit. K Antagonist

18
Q

Half life of protein C,S

A

12 hrs

19
Q

Half life of clotting factors 2,7,9,10

A

5 days

20
Q

Antidote of Dabigatran

A

Idarucizumab

21
Q

Antidote of apixaban (factor Xa inhibitors)

A

Andexanet