Hematology Kwong Flashcards
Causes of neutrophilia
pyogenic infection
reactive - to malignancy, bleeding
Causes of lymphocytosis
chronic lymphocytic leukemia
and associated conditions
Causes of eosinophilia
drug reaction
skin conditions
(parasitic infestation not in HK)
What do you look for in manual differential count
immature myeloid cells
circulating blasts
What else to look for in CBC if there is leukocytosis?
What should you do next if what you looked for was abnormal?
If isolated leukocytosis, what should you consider?
platelet count and hemoglobin
if abnormal –> ask for manual differential count
if isolated –> 5part differential count clinically compatible? if not –> ask for manual differential count
leukocytosis + normal Hb and platelet count - likely cause?
what would you see in wbc differential count?
infective/ reactive
neutrophilia
leukocytosis + increased Hb + thrombocytosis likely cause?
what would you see in wbc differential count?
what to do next?
MPN
myeloid cells of various stages
BM cytochemistry and cytogenetics
leukocytosis + anemia + thrombocytopenia likely cause?
what would you see in wbc differential count?
what to do next?
leukemia
myeloblasts/lymphoblasts
BM cytochemistry and cytogenetics
CML is the proliferation of predominantly the _______________.
myeloid lineage
PV is the proliferation of predominantly the _______________.
erythroid lineage
ET is the proliferation of predominantly the _______________.
megakaryocytic lineage
JAK 2 mutation is present in
all PV, half of ET and MF, less in AML and MDS
All PV, half of ET and MF, AML and MDS have what kind of mutation
JAK 2 mutation
Which leukemia has the lowest incidence in asian population but highest incidence in westerners?
CLL
Which type of leukemia has the lowest incidence in asian population but highest incidence in westerners?
CLL
