Hematology & Coagulation Flashcards
What is the job of neutrophils?
first line of defense; phagocytosis; inflammation; help protect your body from infections by killing bacteria, fungi, and foreign debris
What is the job of lymphocytes?
adaptive immune response; consists of T cells, natural killer cells, and B cells to protect against viral infections and produce proteins to help you fight infection (antibodies)
What is the job of monocytes?
defend against infection by cleaning up damaged cells - antigen-presenting cells (clean house)
What is the job of eosinophils?
identify and destroy parasites, and cancer cells, and assist basophils with your allergic response - hypersensitivity, inflammation phagocytes
What is the job of basophils?
produce allergic responses like coughing, sneezing, or a runny nose - inflammation coordination
Normal % of Neutrophils
60-70%
Normal % of Lymphocytes
20-25%
Normal % of Monocytes
3-8%
Normal % of Eosinophils
2-4%
Normal % of Basophils
0.5-1%
What contents are in plasma?
Proteins (Albumin, Globulins, Fibrinogen, Prothrombin); Water; Other solutes (ions, nutrients, waste products, gases, regulatory substances)
What contents are in formed elements?
Platelets; Leukocytes; Erythrocytes
What cells are part of the Myeloid line?
RBCs, WBCs, platelets
What cells are part of the Lymphoid line?
immune cells (B cells and T cells)
What is the most abundant plasma protein?
Albumin
What is the lifespan of a RBC?
120 days
Where do RBCs go to die?
Spleen - macrophages eat them and dispose of toxic components
Heme ring is carried on albumin as ________ and taken to the liver where it’s converted to ________.
bilirubin; urobilinogen
What are the two pathways that urobilinogen can go?
1) leave the body via kidney or stool
2) recycled through entero-hepatic circulation
Why is Vitamin C important in relation to blood?
acts as a co-factor to promote easier absorption of iron from plant-based foods
What activates Protein C & C?
Vitamin K
What does vWF do?
circulates in blood carrying factor 8 & promotes platelet adhesion to endothelial surfaces as well as platelet aggregation (coagulation)
