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Medicine Revision > Hematology > Flashcards

Hematology Flashcards

1
Q

ADAMTS13

A

It’s VWF cleaving enzyme and associated with TTP

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2
Q

TTP Symptoms

A 
Fever
AKI
Neuro ( seizure , Stroke , delirium )
Low platelets
Hemolytic anemia
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3
Q

HUS

A 
Fever ( diarrhea before due to E.coli )
AKI
Hemolytic anemia 
Low platelets 
NO NURO
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4
Q

TTP Vs HUS

A

HUS : diarrhea , No Neuro , AKI with higher creatinine

TTP : ADAMTS13 , With neuro , less AKI

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5
Q

Schistocytes seen in

A

DIC
TTP
HUS

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6
Q

Waldenstrom Macroglobulinemia

A

Disorder of the B-cell ( IgM )

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7
Q

Waldenstrom Macroglobulinemia presentation

A

Hyperviscosity ( High IgM )
Cryoglobulunemia ( Raynaud phenomenon )
Cold agglutinins disease

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8
Q

Waldenstrom Macroglobulinemia Dx

A

Bone marrow biopsy

Dutcher bodies +IgM

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9
Q

MUGS

A

Monoclonal gammopathy of undetermined significance
This is the precursor of two diseases
1. Multiple Myeloma ( IgG + IgA )
2. Walden storm macroglobulenemia

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10
Q

Amyloidosis Major sites of clinically important dispositions

A

Kidney
Heart
Liver

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11
Q

Amyloidosis DX

A

Tissue biopsy with Congo red staining.

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12
Q

Esophageal cancer

A

Barret - Adenocarcinoma

Plummer Vinson - Sqamous cell carcinoma

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13
Q

Prussian blue

A

It’s spider oblast is anemia

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14
Q

Bite cells + Hence bodies

A

G6PD

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15
Q

Coombs +

A

Autoimmune heamolysis

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16
Q

Reedstenberg

A

Hodgkin disease

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17
Q

High RDW

A

It’s only Iron deficiency Anemia

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18
Q

Aur rods

A

AML

19
Q

Iron deficiency Anemia 2 only’s

A
  • High RDW.

- Low ferritin. ( ferritin t store t )

20
Q

hypersegmented neutrophils

A

Folate + B12 deficiency

21
Q

Target Cell

A

Thalassemia

22
Q

All RBC production problems give you

A

Low retic count .. Either Folate + B12 or Thlasemia and iron def etc

No contents of the retic how we gonna make the retics

23
Q

The only Low MCV and High retic Count is

A

3 gene deletion

24
Q

Hypothyroidism Anemia is

A

Macrocytic Anemia
This Big MCV one
Also liver disease Macrocytic

25
Q

Very Well known medication that cause Folate deficiency

A

Phenytoin

26
Q

Reticulocytes

A

Larger Cells than RBs

They are retained placenta BIG ones

27
Q

Very low Hematocrit

Very low Hgb

A

25-30

8-10

28
Q

1 unit of Packed RBC

A

Raise the hematocrit (3 points)

Raise the Hgb ( 1 point )

29
Q

Warfarin Overdose reversed by

A

PCC
Prothrombin complex concentrate 2 7 9 10
NOT FFP

30
Q

Tx.
Hemophilia A&B
VWD

A

Factor 8 or 9 / Desmopressin DDVAP

Factor 8 or / Desmopressin DDVAP

31
Q

NOAC Overdose

A

Idarusizumab

32
Q

FFP Replaces

A

Clotting Factors

It’s need blood type

33
Q

Hepcidin

A

Keep in the iron Trapped in the Store so you can’t use it

34
Q

Anisocytosis

A

Unequal RBC sizes

35
Q

HIT

A

IgG AB Against PF4
4-10 days after heparin
More than 50% drop in platelets count
TX is stop heparin + foundaparinux / argatroban / lipirudin
Complications: Arterial and venous thrombosis

36
Q

Wells score

A

Risk assessment for DVT

37
Q

Thalassemia minor labs

A

RBC count normal
Hgb normal
RDW normal
EXCEPT Low MCV

38
Q

Only thing change in the lab of thalassemia minors patient is

A

Low MCV .. It’s microcytic anemia

39
Q

Thalassemia Chromosomes
A thalassemia
B thalassemia

A

Chr.16

Chr.11

40
Q

Most Accurate test for Thalasemia diagnosis

A

Genetic testing
It’s autosomal recessive disease so
A thalassemia Chr.16
B thalassemia Chr.11

41
Q

Normal Adult Hemoglobin component

A

A :97%
A2 : 2 %
F: 1%

42
Q

Disorder in the heme part of the Hgb is two

A

Heme - Iron def / Chronic disease

Protoporphyrin- Sideroblastic

43
Q

Tumor lysis syndrome

A

Associated with hematologic malignancies After initiation of cytotoxic
Chemotherapy
1. High P ( phosphate and Potassium ) + Uric acid
2.Low Calcium ( the phosphate bind the calcium so more phosphate with bind more Ca making it low )

Manage with:
Fluids
Allopurinol + Rasburcase “ lowers uric acid “
Monitor the Arrhythmia’s ( because of Ca + K abnormality )

Medicine Revision (5 decks)

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