Hematology Flashcards
Conditions associated with low serum iron?
Iron deficiency Inflammation Hypoproteinemia Hypothyroidism Renal disease
Conditions associated with high Serum iron
Hemolytic anemia
RBC lysis during sampling
Glucocorticoid excess (dog & horse; cattle it caused lower SI)
Iron overload (Fe toxicity or hereditary-hemochromatosis)
Non-regenerative anemia
Species affected by hemochromatosis?
Saler cattle Rhinos Toucans Myna (bird) Dolphins
Causes of microcytosis (low MCV)?
Immature animals
Iron deficiency
PSS
Asian breeds (Akita, Chow-Chow, Shar Pei, Shiba Inu)
Causes of macrocytosis
Reticulocytosis
Breed associates (Grehounds, Giant Schnauzer), Poodles, Alaskan Malamutes (hereditary stomocytosis w/ macrocytosis)
FeLV-infected cats
RBC agglutination (artifactual increase)
Deficiencies of which pathway are associated with hemolytic anemia?
Embden-Meyerhof pathway
Anaerobic glycolysis that produces ATP and NADH-reduced methemoglobin
What molecule does hemoglobin bind to in plasma
Haptoglobin
Babesia in cattle
B. bovis
B. bigemina
Hemotrophic mycoplasma of cattle
M. wenyonii
Cause of eccentrocytes
Oxidative injury
Hb oxidized and pushed off centre
Effect of lead on RBCs
Inhibits heme synthesis
RBC morph: schizocytes
Fibrin strand injury
Eg. DIC, hemangiosarcoma
Acathocytes
Hemangiosarcoma
Erythrocyte change associated with rattlesnake venom
Echinocytosis
