Hematology Flashcards
Fluid medium of the blood; Non-cellular part of the blood
Plasma
Plasma minus the clotting proteins
Serum
Plasma Composition: Water
90%
Plasma Composition: Plasma protein
8%
Plasma Composition: Inorganic salts
1%
Plasma Composition: Lipids
0.5%
Plasma Composition: Sugar
0.1%
Essential component of clotting system
Blood Coagulation Proteins
Major contributors to osmotic pressure of plasma
Albumin
Proteases, Anti-proteases, Transport Proteins
Alpha Globulins
Transferrin & Other Transport Proteins
Beta Globulins
Immunoglobulins
Gamma Globulins
Major ECF Cation
Na
Carried to sites of breakdown or excretion
Organic Wastes
Process of forming blood elements in the bone marrow
Hemopoeisis
Site of blood cell formation beginning 3rd week of fetal development
Yolk sac/Aorta Gonad Mesonephros (AGM) Region
Site of blood cell formation beginning 3rd month of fetal development
Liver (with minor contributions from spleen, LN)
Only sources of blood cells post natally; begins at 4th month
Bone marrow
All Bone marrow active
Birth to Puberty
Only Bone marrow of vertebra, ribs, sternum, skull, pelvis, proximal epiphyseal region of humerus active
Age 30 (remaining marrow: yellow, fatty, inactive)
Post-embryonic extramedullary hematopoiesis in full term infant
Always abnormal
Most abundant blood cells that transport Hemoglobin that carries O2 and CO2, acts an acid-base buffer
Erythrocyte (RBC)
An enzyme that catalyzes the reaction between CO2 & H2O to form carbonic acid (H2CO3)
Carbonic anhydrase
Normal resting shape of RBC
Biconcave disc (due to spectrin) with bag pliability
Protein inside the RBC that bonds with Oxygen; Composed of 4 polypeptide subunits (2 alpha and 2 beta)
Hemoglobin
The % of cells in whole blood
Hematocrit
How many oxygen molecules can 1 hemoglobin molecule bind?
4 molecules of O2
Most common form of hemoglobin in adult human being
HbA (Hemoglobin A)
Has a higher affinity for O2 compared to HbA
HbF (Fetal Hemoglobin)
An essential metallic component of Heme
Iron
Total iron in the body
4-5g
RBC Formation: With nucleus, ER reabsorbed
Orthochromatic Erythroblast
RBC Formation: Baby RBCs; Without nucleus, With remnants of Golgi, Mitochondria and other organelles
Reticulocytes
Hormone stimulating RBC production
Erythropoeitin (EPO)
Main stimulus for EPO production
Hypoxia
Effect of EPO is seen after
5 days
Last RBC stage with nucleus
Orthochromatic Erythroblast
RBC stage released to the blood
Reticulocytes
Time to convert reticulocytes to RBC
1-2 days
Characteristic of Mature RBCs
No nucleus, mitochondria, ER
Lifespan of RBCs
120 days (adult), 90 days (fetal)
Intravascular destruction of old or damaged RBCs occurs here
Spleen
Extravascular destruction of RBCs is due to
Macrophages
Fate of Heme in destroyed RBC
Bilirubin
Nutrient essential for DNA synthesis
Vit B12 and Folic Acid
Megaloblastic Anemia + Neural deficits
Vit B12 Deficiency
Megaloblastic Anemia + Neural Tube Disorders
Folic Acid Deficiency
Needed to absorb Vit B12
Intrinsic Factor
Sources of Vit B12, Folic Acid
Vit B12: meatsFolic Acid: Cauliflower, Broccoli
Capability of the body to resist almost all types of organisms or toxins that tend to damage tissues and organs
Immunity
Pre-existing; Not acquired through contact with non-self; Non-specific; Quick; 1st line of Defense
Innate Immunity
Antibody mediated or Lymphoid Cells; Occurs after exposure to an antigen; Specific; Delayed response; 2nd line of Defense
Acquired Immunity
Basophils, eosinophils, neutrophils
Granulocytes/PML/Myeloid Cells
Monocytes, Lymphocytes
Agranulocytes
Production: Granulocytes and Monocytes
Bone marrow