Hematology Flashcards

1
Q

What is Hematopoiesis

A

The production of RBC

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2
Q

What is the common cell that creates all blood cells

A

Pluripotent hematopoietic stem cell (HSC)

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3
Q

Why are anticoagulants needed

A

To prevent clotting

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4
Q

What is plasma

A

Whole blood minus the cells

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5
Q

What is serum

A

Whole blood minus the cells and clotting factors

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6
Q

List 2 of the most useful pieces of information that most automated hematology analyzer’s generate

A

WBC AND RBC COUNT

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7
Q

What is packed cell volume and why is it important

A

The % of whole blood that is composed of RBC. It can indicate anemia or dehydration

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8
Q

What is the most abundant WBC in dogs

A

Neutrophils

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9
Q

What is the most abundant WBC in ruminants

A

Lymphocytes

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10
Q

List 2 groups of cells that are evaluated for morphology

A

RBC and WBC

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11
Q

What are reticulocytes

A

Immature erythrocytes that contain ribosomes that are lost as the cells mature

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12
Q

Where are all blood cells made

A

Red bone marrow

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13
Q

As the water in the blood decreases, the packed cell volume and total plasma proteins __________

A

Increase

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14
Q

-penia

A

Decrease number of cells in the blood

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15
Q

-Philia or -cytosis

A

Increased number of cells in the blood

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16
Q

Increased number of immature neutrophils in the blood is referred to as

A

Left shift

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17
Q

Destruction of RBC is referred to as

A

Hemolysis

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18
Q

TRUE OR FALSE
Any samples of blood that are not tested within 1 hour must be refrigerated

A

True

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19
Q

TRUE OR FALSE
heparin can not alter WBC morphology

A

FALSE
It interferes with staining of WBC morphology

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20
Q

TRUE OR FALSE
EDTA does not alter cell morphology

A

TRUE
it is the preferred anticoagulant for hematologic studies

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21
Q

What order should blood be put into lab tubes by color

A

Blue
Red
Tiger top
Green or tan
Purple
Gray

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22
Q

Blue tops contain

A

Sodium nitrate

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23
Q

Red tops contain

A

No additives

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24
Q

Green or tan tops contain

A

Heparin

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25
Q

Purple tops contain

A

EDTA

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26
Q

Gray tops contain

A

Potassium oxalate or sodium fluoride

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27
Q

Blue tops are used for

A

Coagulation studies

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28
Q

Red tops are used for

A

Serum for blood chemistry

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29
Q

Green or tan tops are used for

A

Plasma for blood chemistry

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30
Q

Purple tops are used for

A

Hematology

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31
Q

Gray tops are used for

A

Coagulation testing

32
Q

Neutrophilia, lymphopenia, and monocytosis due to increased cortisol levels

A

Stress leukogram

33
Q

Hemolysis is

A

Breakdown of RBC

34
Q

TRUE OR FALSE
The needle can be left on the syringe before transferring blood to a blood tube

A

False
The needle should be removed to prevent hemolysis

35
Q

A manual blood count is preferred on what species

A

Avians

36
Q

Increased number of circulating red blood cells is called

A

Polycythemia or erythrocytosis

37
Q

Increased PCV and Hemoglobin concentrations can indicate what

A

Dehydration

38
Q

What is icteric

A

Yellowing of mm and other parts of the body can indicate liver damage

39
Q

High concentrations of emulsified fat in the blood

A

Lipemia

40
Q

What type of analyzer ?
Classifies cells based on their sizes, give quantitative info about cell populations

A

Impedance

41
Q

What type of analyzer ?
Provide estimated cell counts

A

Quantitative buffy coat

42
Q

What type of analyzer ?
Count and classify cells based on their size and density

A

Laser based flow cytometer analyzers

43
Q

The buffy coat consists of what

A

WBC and platelets

44
Q

Serum that appears cloudy is described as

A

Lipemic
This could be because the patient was not fasted properly prior to blood collection

45
Q

Normal PCV value for a canine is

A

37-55

46
Q

The normal PCV value for a feline is

A

30-45

47
Q

The normal PCV value for equine is

A

32-57

48
Q

The normal PCV value in bovine is

A

24-42

49
Q

What is hemoglobin

A

Iron and chains of amino acids

50
Q

MCV=

A

Mean corpuscular volume

51
Q

MCH=

A

Mean corpuscular hemoglobin

52
Q

MCHC=

A

Mean corpuscular hemoglobin concentration

53
Q

What does MCV measure

A

The average size of the erythrocytes

54
Q

What does MCH measure

A

Mean weigh of the hemoglobin

55
Q

What are 3 reasons blood smears performed

A
  1. WBC count
  2. Estimate platelet numbers
  3. Evaluate morphological features of RBC and WBC
56
Q

Canines and felines with neutrophils that have more than 5 lives present are considered _____ and thus usually attributes to aging of neutrophils

A

Hypersegmented

57
Q

Common changes in neutrophils associated with inflammation, infection, and or drug toxicity

A

Toxic change

58
Q

What is a smudge cell

A

Degenerated WBC that has ruptured

59
Q

A degenerative change to the nucleus of a WBC characterized by dissolution of nuclear membrane; associated with septic exudates

A

Karyolysis

60
Q

What is intracytoplasmic inclusion of a WBC

A

Inclusions in the WBC from infectious diseases

61
Q

Fragmentation of the nucleus after cell death

A

Karyorrhexis

62
Q

Condensing of the nucleus after the cell dies

A

Pyknosis

63
Q

Results in bridging and clumping of RBC and will not disperse when saline is added to the slide. This occurs in immune mediated disorders

A

Autoagglutination or agglutination

64
Q

Grouping of RBC in stacks that will disperse with the addition of saline, normal to see in healthy horses, pigs, and cats

A

Rouleaux

65
Q

Variation in the size of RBC

A

Anisocytosis

66
Q

Increased staining of RBC

A

Polychromasia

67
Q

Also called spur cells; irregular spiculated RBC with a few unevenly distributed surface projections.

A

Acanthocyte

68
Q

Also called burr cells; spicualted RBC with numerous short, evenly spaced blunt to sharp surface projections of uniform size and shape.

A

Echinocytes

69
Q

Echinocytes are typically seen in

A

Snake bites in dogs, drying of blood smears or little blood mixed with EDTA

70
Q

Acanthocytes can be seen in

A

Patient with altered lipid metabolism or cancer

71
Q

Basophilic nuclear ruminants that are seen in young RBC during response to anemia (RBC will have prominent dots in it)

A

Howell jolly bodies

72
Q

WBC that is a helper cell and produces antibodies

A

Lymphocytes

73
Q

Rare WBC seen in antihistamine response

A

Basophils

74
Q

WBC that mainly kills parasites and fungi

A

Eosinophils

75
Q

Clean of crew of WBCs

A

Monocytes

76
Q

Phagocytic WBC

A

Neutrophils

77
Q

Round structures present that represent denatured hemoglobin and that are caused by certain oxidant drugs or chemicals (Lead poisoning)

A

Heinz body