Hematology Flashcards
Which 5 drugs are used for Chronic Myeloid Leukemia?
Boselif, Gleevec, Iclusig, Sprycell and Tasigna
What is the generic name for Gleevec?
imatinib
Which of the drugs that are used for Chronic Myeloid Leukemia list QTc prolongation as a possible SE?
Bosulif, Sprycel and Tasigna; for Tasigna, it is a BBW
Which of the drugs that are used for Chronic Myeloid leukemia need to be taken with food?
Bosulif and Gleevec
Which of the drugs that are used for Chronic Myeloid leukemia need to be taken on an empty stomach?
Tasigna
Which medications interact with Gleevec (imatinib)?
acetaminophen, ibuprofen and warfarin
Which of the drugs that are used for Chronic Myeloid leukemia interact with PPIs or H2-agonists?
Bosulif (bosutinib) with PPIs and Sprycel (dasatinib) interacts with both
Which of the drugs that are used for Chronic Myeloid leukemia have a Black Box Warning?
Iclusig (ponatinib), for arterial thrombosis and hepatotoxicity
Tasigna (nilotinib), for QTc prolongation and sudden death
Which drugs are used for Chronic Lymphocytic Leukemia?
Calquence, Copiktra, Imbruvica, Venclexta, Zydelig
Which of the drugs used for Chronic Lymphocytic Leukemia interact with grapefruit?
Calquence and Imbruvica
Which of the drugs used for Chronic Lymphocytic Leukemia requires prophylaxis for Pneumocystis Jirovechi (PJP)?
Copiktra
Which drugs are used for Chronic Lymphocytic Leukemia is a Bruton TKI?
Imbruvica
Which drugs are used for Chronic Lymphocytic Leukemia should be supplemented with allopurinol?
Imbruvica and Venclexta
Why does Venclexta hava a ramp-up dose, and what is it?
Venclexta’s ramp-up schedule is due to the risk of TLS
CLL/SLL: wk1 20mg qd, wk2 50mg qs, wk3 100mg qd, wk4 200mg qs, wk5 400mg qd
AML: 100mg day1, 200mg day2, 400mg day3
Which of the drugs used for Chronic Lymphocytic Leukemia is used in combination with Rituximab?
Zydelig, and it may cause embryo-fetal toxicity
Which of the drugs used for Chronic Lymphocytic Leukemia have a Black Box Warning?
Copiktra (fatal and/or serious toxicities, infections, diarrhea or colitis, cutaneous reactions, pneumonitis) and Zydelig (hepatotoxicity, severe diarrhea or colitis, pneumonitis, intestinal perforation)
Which specialty drugs treat Acute Myeloid Leukemia?
Daurismo, Idhafa, Rydapt, Tabloid, Tibsovo, Venclexta, Xospata
Which specialty drugs for Acute Myeloid Leukemia have a Boxed Warning?
Daurismo has a BBW for embryo-fetal toxicity. Idhifa, Tibsovo and Xospata have a BBW for differentiation syndrome.
Which specialty drugs are indicated for relapsed or refractory Acute Myeloid Leukemia with an IDH mutation?
Idhifa (IDH2 mutation) and Tipsovo (IDH1) mutation
Which specialty drugs are indicated for FLT3+ mutated Acute Myeloid Leukemia?
Rydapt and Xospata
Which of the specialty drugs used for Acute Myeloid Leukemia carries a risk of QTc prolongation?
Daurismo, Tibsovo and Xospata
Which of the specialty drugs used for Acute Myeloid Leukemia should be taken with food, approximately 12 hours apart?
Rydapt
Which of the specialty drugs used for Acute Myeloid Leukemia blocks purine synthesis?
Tabloid
What is Complete Remission in Acute Myeloid Leukemia?
Bone Marrow <5% blasts ANC >1000/mcL platelets >/= 100,000/mcL transfusion independent no evidence of extramedullary disease
