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Oncology 15% > Hematology > Flashcards

Hematology Flashcards

1
Q

Which 5 drugs are used for Chronic Myeloid Leukemia?

A

Boselif, Gleevec, Iclusig, Sprycell and Tasigna

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2
Q

What is the generic name for Gleevec?

A

imatinib

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3
Q

Which of the drugs that are used for Chronic Myeloid Leukemia list QTc prolongation as a possible SE?

A

Bosulif, Sprycel and Tasigna; for Tasigna, it is a BBW

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4
Q

Which of the drugs that are used for Chronic Myeloid leukemia need to be taken with food?

A

Bosulif and Gleevec

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5
Q

Which of the drugs that are used for Chronic Myeloid leukemia need to be taken on an empty stomach?

A

Tasigna

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6
Q

Which medications interact with Gleevec (imatinib)?

A

acetaminophen, ibuprofen and warfarin

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7
Q

Which of the drugs that are used for Chronic Myeloid leukemia interact with PPIs or H2-agonists?

A

Bosulif (bosutinib) with PPIs and Sprycel (dasatinib) interacts with both

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8
Q

Which of the drugs that are used for Chronic Myeloid leukemia have a Black Box Warning?

A

Iclusig (ponatinib), for arterial thrombosis and hepatotoxicity
Tasigna (nilotinib), for QTc prolongation and sudden death

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9
Q

Which drugs are used for Chronic Lymphocytic Leukemia?

A

Calquence, Copiktra, Imbruvica, Venclexta, Zydelig

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10
Q

Which of the drugs used for Chronic Lymphocytic Leukemia interact with grapefruit?

A

Calquence and Imbruvica

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11
Q

Which of the drugs used for Chronic Lymphocytic Leukemia requires prophylaxis for Pneumocystis Jirovechi (PJP)?

A

Copiktra

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12
Q

Which drugs are used for Chronic Lymphocytic Leukemia is a Bruton TKI?

A

Imbruvica

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13
Q

Which drugs are used for Chronic Lymphocytic Leukemia should be supplemented with allopurinol?

A

Imbruvica and Venclexta

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14
Q

Why does Venclexta hava a ramp-up dose, and what is it?

A

Venclexta’s ramp-up schedule is due to the risk of TLS
CLL/SLL: wk1 20mg qd, wk2 50mg qs, wk3 100mg qd, wk4 200mg qs, wk5 400mg qd
AML: 100mg day1, 200mg day2, 400mg day3

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15
Q

Which of the drugs used for Chronic Lymphocytic Leukemia is used in combination with Rituximab?

A

Zydelig, and it may cause embryo-fetal toxicity

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16
Q

Which of the drugs used for Chronic Lymphocytic Leukemia have a Black Box Warning?

A

Copiktra (fatal and/or serious toxicities, infections, diarrhea or colitis, cutaneous reactions, pneumonitis) and Zydelig (hepatotoxicity, severe diarrhea or colitis, pneumonitis, intestinal perforation)

17
Q

Which specialty drugs treat Acute Myeloid Leukemia?

A

Daurismo, Idhafa, Rydapt, Tabloid, Tibsovo, Venclexta, Xospata

18
Q

Which specialty drugs for Acute Myeloid Leukemia have a Boxed Warning?

A

Daurismo has a BBW for embryo-fetal toxicity. Idhifa, Tibsovo and Xospata have a BBW for differentiation syndrome.

19
Q

Which specialty drugs are indicated for relapsed or refractory Acute Myeloid Leukemia with an IDH mutation?

A

Idhifa (IDH2 mutation) and Tipsovo (IDH1) mutation

20
Q

Which specialty drugs are indicated for FLT3+ mutated Acute Myeloid Leukemia?

A

Rydapt and Xospata

21
Q

Which of the specialty drugs used for Acute Myeloid Leukemia carries a risk of QTc prolongation?

A

Daurismo, Tibsovo and Xospata

22
Q

Which of the specialty drugs used for Acute Myeloid Leukemia should be taken with food, approximately 12 hours apart?

23
Q

Which of the specialty drugs used for Acute Myeloid Leukemia blocks purine synthesis?

24
Q

What is Complete Remission in Acute Myeloid Leukemia?

A 
Bone Marrow <5% blasts
ANC >1000/mcL
platelets >/= 100,000/mcL
transfusion independent
no evidence of extramedullary disease
25
Q

Which medications are used for Acute Myeloid Leukemia when there are no mutations?

A

Duarismo, Venclexta, Tabloid

26
Q

Which medication is for Acute Myeloid Leukemia with R123 mutation?

27
Q

Which LDD is used for Hodgkin’s Disease?

A

Matulane, and fermented foods should be avoided

28
Q

Which medication is used for EZH2 mutated relapsed or refractory follicular lymphoma?

29
Q

Which nuclear export inhibitor is used for relapsed or refractory diffuse large B-cell lymphoma?

30
Q

Which histone deacetylase inhibitor is used for cutaneous T-cell lymphoma?

31
Q

What are the monitoring parameters for multiple myeloma?

A

Calcium levels >11
Renal function (CrCl 40mL/min)
Anemia (hemoglobin <10g/dL)
Bone lesions (at least one active)

32
Q

What are the 6 medications used for multiple myeloma?

A

Farydak, Ninlaro, Pomalyst, Revlimid, Thalomid, Xpovio

Oncology 15% (3 decks)

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