Breast Cancer Flashcards
1
Q
Xeloda
A
- capecitabine
- Pyrimidine antimetabolite
- With food
2
Q
Afinitor
A
everolimus
mTor inhibitor
W/exemestane
No grapefruit
3
Q
Ibrance
A
- palbociclib
- CD4/6 inh
- W/aromatase inhibitor or fulvestrant
- caps w/food
- Tabs and caps are not interchangeable
4
Q
Kisqali
A
- ribociclib
- CD4/6 inh W/aromatase inh or fulvestrant
- QTc prol
- Avoid grapefruit
5
Q
Verzenio
A
- abemeciclib
- CD4/6 inh aromatase inh or fulvestrant+ GRHA such as leupron
- can be used as mono therapy
- diarrhea
6
Q
Nerlynx
A
- neratinib
- Irreversible TKI, EGFR inh
- use loperamide
- with food
- avoid grapefruit
7
Q
Piqray
A
- alpelisib
- PI3K inh
- +fulvestrant
- W/food
8
Q
Tykerb
A
- lapatinib
- HER+/HER2+ advanced or metastatic BC
- BBW: hepatotoxicity
- Tykerb/Xeloda; without food/with food
- LOTs of tablets
- no grapefruit
9
Q
Talzenna
A
- talazoparib
- must conf BRCA mutation
- PARP inh
10
Q
Lynparza
A
- olaparib
- PARP
- BRCA mutation conf
11
Q
Which 3 types of solid organ cancers are treated by Afinitor (everolimus)?
A
breast, renal and neuroendocrine
12
Q
Which 3 types of solid organ cancers are treated by Lynparza (olaparib)?
A
breast, gynecologic and pancreatic
13
Q
Which 2 types of solid organ cancers are treated by Xeloda (capecitabine)?
A
breast and colorectal
14
Q
Which 6 mechanisms of action are used to treat breast cancer?
A
- pyrimidine antimetabolite
- mTOR inhibitor
- CDK4/6 inhibitor
- Tyrosine Kinase Inhibitor (TKI)
- HER1, HER2, HER4
- EGFR
- PhosphatidyLinositol-3-Kinase (Pl3K) Inhibitor
- Poly (ADP-ribose) polymerase (PARP) enzyme Inhibitor
