Hematologic Disorders Flashcards

1
Q

A newly circumcised infant is till bleeding an hour after the circumcision. Your differential diagnosis would include the following except:

a. Wiskott-Aldrich Syndrome
b. Von Willerbrand Disease
c. Sickle Cell Anemia
d. Hemophilia

A

c. Sickle Cell Anemia

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2
Q

A 5 year old is brought to the clinic. Her mother reports that she has been lethargic and has been running low grade fever for about 2 weeks. Physical exam reveals no significant findings other than pallor and lymphadenopathy. A complete blood count reveals decreased hematocrit, neutropenia and thrombocytopenia. The practitioner’s next action would be:

a. Refer child to a pediatric hematologist/ oncologist for further evaluation
b. Instruct parents the appropriate use of acetaminophen to treat the child’s fever
c. Reassure parents that their daughter’s signs and symptoms are indicative of viral infection
d. Prescribe a broad-spectrum antibiotic and ferrous sulfate

A

a. Refer child to a pediatric hematologist/ oncologist for further evaluation

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3
Q

Which of the following tests is required to diagnose leukemia?

a. CBC with differential
b. Chest radiograph
c. Bone marrow aspiration/ biopsy
d. Biopsy of an enlarged lymph node

A

c. Bone marrow aspiration/ biopsy

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4
Q

Which malignancy is associated with genitourinary anomalies?

a. Osteosarcoma
b. Acute lymphocytic leukemia
c. Chronic myelogous leukemia
d. Wilm’s tumor

A

d. Wilm’s tumor

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5
Q

Which of the following statements is true about immunizations during treatment of childhood cancer?

a. No family member should be immunized while the child is receiving chemotherapy
b. Children continue to receive immunization as usual
c. Only live vaccines are held during active chemotherapy
d. Immunizations are not given during active chemotherapy

A

d. Immunizations are not given during active chemotherapy

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6
Q
Which characteristics is not a feature of DiGeorge Syndrome?
a.
Frontal bossing
b.
Cleft palate
c. Hypertelorism
d.
Cardiac defects
A

a.

Frontal bossing

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7
Q

The diagnostic finding that is pathognomonic for Wiskott-Aldrich Syndrome?

a. Small platelets (low mean platelet volume)
b. Absent B cells
c. CD4 cytopenia
d. Decreased hemoglobin

A

a. Small platelets (low mean platelet volume)

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8
Q

Management of a patient with splenectomy does not include:
a.
Blood culture and parenteral antibiotics for febrile illnesses
b. Pneumococcal vaccines at least 2 weeks prior to surgery
c.
Prophylactic penicillin
d. Treating fever with antipyretics only and observing for resolution

A

d. Treating fever with antipyretics only and observing for resolution

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9
Q
Which of the following blood levels is not considered lead poisoning?
a.
>25 ug/dL
b. <5 ug/ dL
c.
10 – 14 ug/dL
d.
>15 ug/ dL
A

b. <5 ug/ dL

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10
Q
Which of the following is not precipitating factor for hemolysis in G6PD deficiency?
a. Drugs
b. Exposure to extreme temperatures
c.
Infection
d.
Ingestion of fava beans
A

b. Exposure to extreme temperatures

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11
Q

The peak incidence of osteosarcoma is:

a. 8-11 years of age
b. 4-7 years of age
c. 12-14 years of age
d. 15-19 years of age

A

d. 15-19 years of age

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12
Q

Which of the following medications should be avoided in a child with ITP?

a. Decongestants
b. Acetaminophen
c. Aspirin
d. Sulfa Drugs

A

c. Aspirin

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13
Q

Which of the followig is not included as part of the initial therapy for A.L.L.?

a. Radiation Therapy
b. Bone marrow transplant
c. Intrathecal chemotherapy
d. Chemotherapy

A

b. Bone marrow transplant

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14
Q

Which of the following is not considered preventative management for iron deficiency anemia?

a. Iron fortified cereal from 6 to 12 months of age
b. If breatfeeding, supplemental iron drops or iron-fortified cereal by 4 to 5 months of age
c. Iron fortified formula until 6 months of age
d. No cow’s milk until 1 year of age

A

c. Iron fortified formula until 6 months of age

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15
Q

The expected clinical severity of hemoglobin sickle C disease (Hgb SC) IS:

a. Mild to moderate
b. Marked to moderate
c. Severe
d. Asymptomatic

A

a. Mild to moderate

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16
Q

Baseline management of all neonates with ABO incompatibility includes:

a. Phototherapy
b. Simple transfusion of packed red blood cells
c. Exchange transfusion
d. Serial monitoring of bilirubin and hemoglobin levels

A

d. Serial monitoring of bilirubin and hemoglobin levels

17
Q

Β-chain synthesis is absent in:

a. B-thalassemia intermediate
b. Α-thalassemia trait
c. B-thalassemia major
d. B-thalassemia minor

A

c. B-thalassemia major

18
Q

Which of the following id most often associated with hemoglobin C?

a. Usually asymptomatic
b. Growth retardation
c. Frontal bossing
d. Hepatosplenomegaly

A

a. Usually asymptomatic

19
Q

Diagnostic findings inconsistent with B thalassemia would be:

a. Hemoglobin - normal
b. Hgb A2 >3.6
c. Reticulocytes - increased
d. Hypochromia, microcytosis

A

a. Hemoglobin - normal

20
Q

Prophylactic penicillin should be initiated in children with sickle cell anemia by:

a. 2 to 3 months of age
b. 3 years of age
c. 12 months of age of age
d. 9 months of age

A

a. 2 to 3 months of age