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KLUBSYBEAR > HEMA QUIZ 3 > Flashcards

HEMA QUIZ 3 Flashcards

1
Q

What is the hematopoietic stem cell marker?

A. CD33
B. CD34
C. CD35
D. CD43

A

B. CD34

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2
Q

Which of the following cytokine can be used to treat anemia in patient with cancer?

A. Interleukin 3
B. EPO
C. GM-CSF
D. IL-2

A

B. EPO

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3
Q

It takes approximately how many days will a BFU-E becomes a mature RBC?

A. 18-21 days
B. 10-15 days
C. 5-10 days
D. 20-25 days

A

A. 18-21 days

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4
Q

Which of the following is not a function of EPO?

A. Promotes apoptosis
B. Decrease the maturation time of RBC precursors
C. Allows early release of reticulocytes from the Bone marrow
D. Increases the rate of extrusion of a red blood cell nucleus (enucleation)

A

A. Promotes apoptosis

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5
Q

What is the major fetal organ that produces EPO?

A. Kidney
B. Liver
C. Lungs
D. Intestine

A

B. liver

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6
Q

The last stage capable of mitosis:

A. Rubricyte
B. Metarubricyte
C. Rubriblast
D. Prorubricyte

A

A. Rubricyte

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7
Q

The first enucleated stage

A. Rubricyte
B. Metarubricyte
C. Reticulocyte
D. Erythrocyte

A

C. Reticulocyte

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8
Q

Extrusion of nucleus or Enucleation takes place at what maturational stage?

A. Rubricyte
B. Metarubricyte
C. Erythrocyte
D. Reticulocyte

A

B. Metarubricyte

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9
Q

What is the term for the extruded nucleus during RBC maturation series?

A. Nucleocyte
B. Pyrenocyte
C. Inclusion
D. Enucleocyte

A

B. Pyrenocyte

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10
Q

With a checkered board chromatin pattern and characterized by a murky-gray blue cytoplasm:

A. Polychromatophilic normoblast
B. Orthochromic normoblast
C. Pronormoblast
D. Polychromatic erythrocyte

A

A. Polychromatophilic normoblast

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11
Q

What is the earliest recognizable stage of the RBC precursor normally found in blood?

A. Rubriblast
B. Polychromatic erythrocyte
C. BFU-E
D. Pronormoblast

A

B. Polychromatic erythrocyte

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12
Q
  1. True about shift reticulocytes

I. Larger
II. Increases during hemolytic anemia
III. Known as stress retics

A. 1,2
B. 1,3
C. 2,3
D. 1,2,3

A

D. 1,2,3

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13
Q

What is the normal bone marrow transit time of a metarubricyte into a reticulocyte?

A. 24hours
B. 48 hours
C. 72 hours
D. 30 hours

A

B. 48 hours

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14
Q

RBC membrane is impermeable to which of the following molecules?

I. Sodium
II. Chloride
III. Potassium

A. 1,2,3
B. 1,2
C. 1,3
D. None of them

A

C. 1,3

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15
Q

What is the most common enzyme deficiency in HMP?

A. G6PD
B. Hexokinase
C. Pyruvate kinase
D. Glucose oxidase

A

A. G6PD

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16
Q

What is the most common enzyme deficiency in EMP?

A. G6PD
B. Hexokinase
C. Pyruvate kinase
D. Glucose oxidase

A

C. Pyruvate kinase

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17
Q

Which of the following RBC process does not require energy?

A. Glycolysis initiation
B. Maintenance of membrane phospholipid
C. Transportation of gases such as oxygen
D. Glutathione synthesis

A

C. Transportation of gases such as oxygen

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18
Q

Which of the following alternate pathways or diversions are derived from Embden-Meyehoff-Glycolytic pathway?

A. Krebs, HMP, Methemoglobin reductase, and Rapoport-Luebering
B. HMP and methemoglobin
C. HMP, Methemoglobin, and Rapoport-Luebering
D. HMP and Krebs

A

C. HMP, Methemoglobin, and Rapoport-Luebering

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19
Q

Most of the energy of the RBCs are derived from what metabolic pathway?

A. EMP
B. HMP
C. Rapoport-Luebering
D. Methemoglobin reductase

A

A. EMP

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20
Q

What is a Bohr effect?

A. A shift of the oxygen dissociation curve due to changes of blood Ph
B. A shift of the oxygen dissociation curve due to changes of body temperature
C. A shift of the oxygen dissociation curve due to the relation of oxygen and carbon dioxide
D. A shift of the oxygen dissociation curve due to saturation level of hemoglobin

A

A. A shift of the oxygen dissociation curve due to changes of blood Ph

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21
Q

Which of the following is not associated with a shift to the right of oxygen dissociation curve?

A. Hemolytic anemia
B. High altitudes
C. Muscular dystrophy with high myoglobin levels
NOTA

A

C. Muscular dystrophy with high myoglobin levels

22
Q

What is the haptoglobin value in macrophage mediated hemolysis?

A. Normal
B. Decreased
C. Increased

A

B. Decreased

23
Q

Extravascular hemolysis is responsible for how many percent of RBC destruction?

90
10
50
100

A

90

24
Q

Which of the following protein is responsible for oxidizing iron before it will bind to transferrin and transported in the circulation?

A. Hepcidin
B. Hepaesthin
C. Ferroportin
D. formalin
Option 5

A

B. Hepaesthin

25
Q

Accumulation of iron stores with little or no parenchymal cell injury:

A. Hemochromatosis
B. Hemosiderosis
C. Hyperferremia
D. Bronzed diabetes

A

B. Hemosiderosis

26
Q

It regulates the transport of iron from enterocyte into the circulation by binding to a transport protein:

A. Ferroportin
B. Hepcidin
C. DMT-1
D. Transferrin

A

B. Hepcidin

27
Q

What is the major transport iron protein in the blood?

A. Ferroportin
B. Ceruloplasmin
C. Albumin
D. Transferrin

A

D. Transferrin

28
Q

A water insoluble compound that is derived from degradation of ferritin and can be seen in urine:

A. Hemosiderin
B. Ferroportin
C. Iron
D. Porphyrin

A

A. Hemosiderin

29
Q

HBA1C is a fraction of hemoglobin A that can be used to monitor blood sugar level and RBC age. A decreased HBA1C is an indicator of:

A. Young RBC
B. Immature RBC
C. Senescent RBC
D. No relation

A

C. Senescent RBC

30
Q

A mauve lavender blood color can be seen in which of the following condition?

A. Sulfanilamide ingestion
B. Chlorate ingestion
C. Carbon monoxide poisoning
D. Tobacco smoking

A

A. Sulfanilamide ingestion

31
Q

A bluish discoloration of skin and mucous membranes due to decrease oxygenation:

A. Anemia
B. Cyanosis
C. Purpura
D. Sulfhemoglobinemia

A

B. Cyanosis

32
Q

What is the methemoglobin level that is associated with coma and death?

> 50
40
30
20

A

> 50

33
Q

The color intensity of cyanmethemoglobin method is measured at what wavelength?

A. 500nm
B. 540nm
C. 600nm
D. 560nm

A

B. 540 nm

34
Q

What hemoglobin method uses yellowish brown glass standard solution for the comparison of results?

A. Hematin method
B. Cyanmethemoglobin method
C. Gasometric
D. Kennedy Wong’s method

A

A. Hematin method

35
Q

What substance should be added as a remedy for removing abnormal globulins during cyanmethemoglobin measurements?

A. Potassium carbonate
B. Potassium sulfate
C. Sodium bicarbonate
D. Acetic anhydride

A

A. Potassium carbonate

36
Q

Aged or senescent RBCs usually appear as:

A. Schistocyte
B. Acanthocyte
C. Spherocyte
D. Codocytes

A

C. Spherocyte

37
Q

An important component within the red blood cell that is responsible for its natural red color:

A. Globin peptides
B. Heme
C. Iron
D. Amino acids

A

B. Heme

38
Q

Which of the following globin chain is composed of 141 amino acids?

A. Beta
B. Delta
C. Gamma
D. Alpha

A

D. Alpha

39
Q

Which of the following is NOT a primary requirement for the production of heme?

A. Succinyl coenzyme A
B. Pyridoxine
C. Zinc
D. Glycine

A

C. Zinc

40
Q

Usage of reagent/patient blank as a remedy for turbid solution is only applicable if the specimen is:

A. Icteric
B. Lipemic
C. Hemolyzed
D. Cloudy

A

B. Lipemic

41
Q

It takes approximately how many minutes a carboxyhemoglobin can be converted into cyanmethemoglobin?

A. 30 minutes
B. 60 minutes
C. 120 minutes
D. 15 minutes

A

B. 60 minutes

42
Q

Which of the following is not an abnormal hemoglobin?

A. HB M
B. HB E
C. HBA1c
D. Bart’s Hb

A

C. HBA1c

43
Q

Which of the following specimen cannot used for determination of hemoglobin using modified Drabkin’s method?

A. Heparinized blood
B. Citrated blood
C. Capillary blood
D. Blood in EDTA

A

B. Citrated blood

44
Q

What is being plotted on the y-axis of the standard hemoglobin curve?

A. Hemoglobin concentration
B. Optical density
C. pH
D. wavelength

A

B. Optical density

45
Q

over-anticoagulation will lead to ___cyanmethemoglobin results

A. False increase
B. False decrease
C. Variable
D. Over anticoagulation will not affect the results

A

D. over anticoagulation will not affect the results

46
Q

How much blood is needed for the standard preparation of cyanmethemoglobin method?

A. 0.02ml
B. 2ul
C. 0.2 ml
D. 200ul

A

A. 0.02ml

47
Q

Most iron in the body is located in the

Hemoglobin
enterocytes
transferrin
macrophages

A

Hemoglobin

48
Q

one gram of hemoglobin can carry __ of iron

1.34mg
3.47mg
4.37mg
1.43mg

A

3.47mg

49
Q

cquired form of porphyria or acquired defect in heme synthesis can be seen in which of the following condition?

porphyria
hemochromatosis
sideroblastic anemia
lead poisoning

A

lead poisoning

50
Q

What is the FEP level in lead poisoning?

High
Lower
normal
borderline

A

High

KLUBSYBEAR (5 decks)

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