Hema-Immuno Flashcards by Christian Linatoc

A patient has been diagnosed with Hodgkin lymphoma with involvement of one lymph node region in the neck without any other findings. What stage lymphoma does this patient have?

A. Stage I
B. Stage II
C. Stage III
D. Stage IV

A. Stage I

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Which of the given CD markers are positive in the nodular lymphocyte-predominant form of Hodgkin lymphoma?

A. CD34, CD41
B. CD3, CD117
C. CD20, CD45
D. CD11, CD91
E. CD15, CD30

C. CD20, CD45

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A child has been diagnosed with Hodgkin lymphoma. She has involvement of the axillary lymph nodes and spleen without involvement of other organs. What is the stage of this lymphoma?

A. Stage I
B. Stage II
C. Stage III
D. Stage IV

C. Stage III

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What is the FIRST choice of treatment for MALT lymphoma that is suspected to be due to H.pylori infection?

A. Montelukast
B. Prednisone
C. NSAIDs
D. Antibiotics
E. Codeine

D. Antibiotics

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Which of the following types of lymphomas is most strongly associated with Epstein-Barr virus infection?

A. MALT lymphoma
B. DLBCL
C. Burkitt lymphoma
D. Mantle cell lymphoma

C. Burkitt lymphoma

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Which of the following cell types gives rise to the Reed-Sternberg cell?

A. T cells
B. Eosinophils
C. Basophils
D. Plasma cells
E. B cells

E. B cells

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A cervical lymph node biopsy from a 10-year-old girl reveals a large cell with a bilobed nucleus with prominent eosinophilic inclusion-like nucleoli resembling an owl’s eye. Which of the following is the most likely diagnosis?

A. AML
B. NHL
C. ALL
D. HL
E. TB

D. HL

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Which translocation is associated with most follicular lymphomas?

A. t(11;18)
B. t(14;18)
C. t(8;14)
D. t(11;14)
E. t(8;21)

B. t(14;18)

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Hodgkin’s lymphoma with mixed cellularity is commonly detected in which stage?

A. Stage I
B. Stage II
C. Stage III/IV
D. Any of the options

C. Stage III/IV

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All of the following are TRUE about NHL EXCEPT:

A. M > F
B. 10x than HL
C. Rises w/ age (>40 yrs)
D. None of the options

D. None of the options

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All of the following may be predisposed to NHL EXCEPT:

A. (+) HIV
B. Undergone organ transplant
C. Inherited immune / autoimmune diseases
D. None of the options

D. None of the options

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Which of the following is most frequently associated w/ immunosuppression and autoimmune diseases?

A. BL
B. DLBCL
C. FL
D. LL
E. None of the options

B. DLBCL

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All of the following are CORRECTLY paired about NHL caused by infections EXCEPT:

A. EBV: Post-organ transplant
B. HLTV-1: Adult T-cell leukemia/lymphoma
C. HIV: FL
D. Hepatitis C: Lymphoblastic lymphoma
E. HHV 8: Effusion lymphoma

C. HIV: FL

HIV: DLBCL

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All of the following are CORRECTLY paired about increased risk of dev’t of malignant lymphomas EXCEPT:

A. Inherited: Ataxia-telangiectasia
B. Acquired: EBV-1 infection
C. Autoimmune: Celiac sprue
D. Drug exposure: Phenytoin
E. None of the options

B. Acquired: EBV-1 infection

Inherited (WACK)
Acquired (IHA)
Autoimmune (CRSS)
Chemical/drug (PPRD)

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All of the following are CORRECTLY paired about most common translocations in NHL EXCEPT:

A. t(8;14): BL
B. t(11;14): AITL
C. t(14;18): FL, DLBCL
D. t(11:18): MALT lymphoma
E. t(9;14): LL

B. t(11;14): AITL

t(11;14): MCL

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All of the following are clinical risk factors in IPI EXCEPT:

A. Age ≥60
B. Elevated serum b2-microglobulin
C. ECOG ≥2
D. Stage III disease
E. >1 site of extranodal involvement

B. Elevated serum b2-microglobulin

All of the following are TRUE about Burkitt’s lymphoma EXCEPT:

A. ~30% of childhood NHL
B. t(8;14)
C. Starry sky appearance
D. Endemic form is EBV (+)
E. None of the options

E. None of the options

All of the following are TRUE about DLBCL EXCEPT:

A. Most common NHL
B. Higher in people w/ first degree relative
C. EBV-related
D. ~40% have “B” symptoms
E. None of the options

All of the following are TRUE about DLBCL EXCEPT:

A. Most common NHL
B. Higher in people w/ first degree relative
C. EBV-related
D. ~40% have “B” symptoms
E. None of the options

E. None of the options

Tumor biopsy of DLBCL:

A. (+) CD19, CD20, CD79a
B. (+) CD2, CD5
C. (+) CD10, CD25
D. (+) CD22, CD 79a

A. (+) CD19, CD20, CD79a

Which of the following is NOT part of the standard first-line for DLBCL?

A. Rituximab
B. Cyclophosphamide
C. Doxorubicin
D. Vinblastine
E. Prednisone

D. Vinblastine

Which of the following is often used to treat primary mediastinal large B-cell lymphoma and double-hit DLBCL?

A. R-CHOP
B. R-EPOCH
C. High dose systemic MTX + leucovorin rescue
D. Salvage therapy + autologous SCT
E. Palliative intentions

B. R-EPOCH

Among the B-cell malignancies, which has been targeted most?

A. CD2
B. CD15
C. CD19
D. CD20
E. CD22

C. CD19

All of the following are TRUE about Follicular Lymphoma EXCEPT:

A. t(14;18)
B. Grade IIIa has >15 centrocytes/hpf
C. Most common presentation is new, painful lymphadenopathy
D. May transform to DLBCL
E. Do not have elevated LDH or fever

C. Most common presentation is new, painful lymphadenopathy

Which of the following NHLs nearly always recurs following therapy? A. BL B. DLBCL C. FL D. MZL E. LPL

C. FL

All of the following are TRUE about Marginal Zone Lymphoma EXCEPT: A. Most common extranodal lymphoma affects the stomach B. Nodal MZL most closely resembles FL C. Splenic MZL has abundant cytoplasm w/ "shaggy" or villous projections D. Treatment include BTK inhibitor - Ibrutinib E. (+) CD10, CD5

E. (+) CD10, CD5

Lymphoplasmacytic lymphoma is mostly associated with what immunoglobulin? A. IgA B. IgE C. IgG D. IgM E. IgD

D. IgM

Pathognomonic finding is translocation of chromosomes 11 and 14 A. MCL B. MZL C. PTCL, NOS D. Mycosis fungoides E. ALCL

A. MCL

Associated w/ reactive eosinophilia and hemophagocytic syndrome A. Mycosis fungoides B. PTCL, NOS C. AITL D. ALCL D. ATLL

B. PTCL, NOS

A 65-year old patient comes into your clinic. He presents with "B" symptoms and pruritus. Upon further examination, you have found out involvement of bone marrow, liver, spleen and skin and gave him CHOP-like chemotherapy backbone. What is the disease of the patient? A. Mycosis fungoides B. PTCL, NOS C. AITL D. ALCL D. ATLL

B. PTCL, NOS

Most closely resembling CD4+ follicular helper T cells A. Mycosis fungoides B. PTCL, NOS C. AITL D. ALCL D. ATLL

C. AITL

Which of the following reveals long latency b/w viral infection and viral transformation of HTLV-1? A. Mycosis fungoides B. PTCL, NOS C. AITL D. ALCL D. ATLL

D. ATLL

A 60-year old man comes into your clinic w/ mass and obstructive symptoms of upper aerodigestive tract. Which of the following is most likely diagnosis? A. Panniculitis B. Extranodal NK/T-cell lymphoma C. Adult T-cell Leukemia/Lymphoma D. Angioimmunoblastic T-cell lymphoma E. Enteropathy T-cell lymphoma

B. Extranodal NK/T-cell lymphoma

All of the following are clinical presentation of SVCS EXCEPT: A. neck and facial swelling B. dyspnea and cough C. bending forward or lying down aggravate the symptoms D. dilated neck veins E. None of the options

E. None of the options

Most significant chest finding in SVCS A. Widening of the right anterior mediastinum B. Widening of the left anterior mediastinum C. Widening of the right superior mediastinum D. Widening of the left superior mediastinum

C. Widening of the right superior mediastinum

Provides the most reliable view of the mediastinal anatomy. A. CT scan B. MRI C. PET D. FDG-PET E. Biopsy

A. CT scan

Has 100% specificity and sensitivity to diagnose SVC obstruction A. CT scan B. MRI C. PET D. FDG-PET E. Biopsy

B. MRI

ALL of the following are TRUE about treatment of SVCS EXCEPT: A. Primary treatment is chemoradiotherapy B. Endovascular therapy is used to provide relief clinical symptoms C. Early stenting is used w/ severe symptoms D. Chemotherapy is used when the underlying cancer is SCLC, lymphoma, or germ cell tumor E. None of the options

A. Primary treatment is chemoradiotherapy