hem/onc

Question 1

antibodies to ABO blood groups are what type?

Answer 1

IgM

Question 2

antibodies to Rh are what type?

Answer 2

IgG

** CAN cross placenta –> erythroblastosis fetalis

Question 3

F VIII deficiency?

Answer 3

hemophilia A

XLR

Question 4

F IX deficiency?

Answer 4

hemophilia B

XLR

Question 5

F XI deficiency?

Answer 5

hemophilia C

AR

Question 6

what is thromboplastin?

Answer 6

same as tissue factor

converts VII –> VIIa

Question 7

what does kallikrein do?

Answer 7

converts HMWK to bradykinin

Question 8

what does bradykinin do?

Answer 8

causes vasodilation, vascular permeability, pain

Question 9

what are the factor Xa anticoagulants?

Answer 9

LMWH (greatest efficacy)
heparin
direct: apixaban, rivaroxaban
fondaparinux

Question 10

what are the factor IIa (thrombin) anticoagulants?

Answer 10

heparin (greatest efficacy)
LMWH
direct: argatroban, bivalirudin, dabigatran

Question 11

what does aminocaproic acid do?

Answer 11

inhibits plasminogen –> plasmin

procoagulant

Question 12

what enzyme does warfarin inhibit?

Answer 12

epoxide reductase (converts oxidized vit K to reduced vit K)

Question 13

what activates protein C?

Answer 13

thrombin-thrombomodulin complex - found in endothelial cells

Question 14

what does protein S do?

Answer 14

helps protein C inactivate Va, VIIIa

Question 15

factor V leiden?

Answer 15

factor V that is resistant to inactivation by protein C

Question 16

what does plasmin do?

Answer 16

cleavage of fibrin mesh

degradation of coagulation factors

Question 17

antithrombin function?

Answer 17

inhibits activated: II, VII, IX, X, XI, XII

** main targets = thrombin and Xa

Question 18

heparin MOA?

Answer 18

enhances antithrombin activity

Question 19

what causes vasoconstriction after endothelial damage?

Answer 19

neural stimulation reflex

endothelin release from damaged cell

Question 20

where does vWF come from?

Answer 20

Weibel Palade bodies of endothelial cells

alpha granules of platelets

Question 21

where does vWF bind?

Answer 21

exposed collagen and GpIb on platelets

Question 22

what does ADP do in platelet aggregation?

Answer 22

helps adhere to endothelium

induces GpIIb/IIIa expression

Question 23

what does fibrinogen bind?

Answer 23

GpIIb/IIIa

Question 24

what does ristocetin do?

Answer 24

activates vWF to bind GpIb

Question 25

deficiency in GpIb?

Answer 25

Bernard Soulier

Question 26

deficiency in GpIIb/IIIa?

Answer 26

Glanzmanns thrombasthenia

Question 27

deficiency in vWF?

Answer 27

VWD

Question 28

which drugs inhibit ADP-induced GPIIb/IIIa expression?

Answer 28

clopidogrel
prasugrel
ticlopidine

Question 29

which drugs inhibit GpIIb/IIIa directly?

Answer 29

abciximab
eptifibatide
tirofiban