Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

step 1 - physiology > hem/onc > Flashcards

hem/onc Flashcards

1
Q

antibodies to ABO blood groups are what type?

A

IgM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

antibodies to Rh are what type?

A

IgG

** CAN cross placenta –> erythroblastosis fetalis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

F VIII deficiency?

A

hemophilia A

XLR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

F IX deficiency?

A

hemophilia B

XLR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

F XI deficiency?

A

hemophilia C

AR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what is thromboplastin?

A

same as tissue factor

converts VII –> VIIa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what does kallikrein do?

A

converts HMWK to bradykinin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what does bradykinin do?

A

causes vasodilation, vascular permeability, pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what are the factor Xa anticoagulants?

A

LMWH (greatest efficacy)
heparin
direct: apixaban, rivaroxaban
fondaparinux

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what are the factor IIa (thrombin) anticoagulants?

A

heparin (greatest efficacy)
LMWH
direct: argatroban, bivalirudin, dabigatran

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what does aminocaproic acid do?

A

inhibits plasminogen –> plasmin

procoagulant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what enzyme does warfarin inhibit?

A

epoxide reductase (converts oxidized vit K to reduced vit K)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what activates protein C?

A

thrombin-thrombomodulin complex - found in endothelial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what does protein S do?

A

helps protein C inactivate Va, VIIIa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

factor V leiden?

A

factor V that is resistant to inactivation by protein C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what does plasmin do?

A

cleavage of fibrin mesh

degradation of coagulation factors

17
Q

antithrombin function?

A

inhibits activated: II, VII, IX, X, XI, XII

** main targets = thrombin and Xa

18
Q

heparin MOA?

A

enhances antithrombin activity

19
Q

what causes vasoconstriction after endothelial damage?

A

neural stimulation reflex

endothelin release from damaged cell

20
Q

where does vWF come from?

A

Weibel Palade bodies of endothelial cells

alpha granules of platelets

21
Q

where does vWF bind?

A

exposed collagen and GpIb on platelets

22
Q

what does ADP do in platelet aggregation?

A

helps adhere to endothelium

induces GpIIb/IIIa expression

23
Q

what does fibrinogen bind?

A

GpIIb/IIIa

24
Q

what does ristocetin do?

A

activates vWF to bind GpIb

25
Q

deficiency in GpIb?

A

Bernard Soulier

26
Q

deficiency in GpIIb/IIIa?

A

Glanzmanns thrombasthenia

27
Q

deficiency in vWF?

A

VWD

28
Q

which drugs inhibit ADP-induced GPIIb/IIIa expression?

A

clopidogrel
prasugrel
ticlopidine

29
Q

which drugs inhibit GpIIb/IIIa directly?

A

abciximab
eptifibatide
tirofiban

step 1 - physiology (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions