hem/onc Flashcards
antibodies to ABO blood groups are what type?
IgM
antibodies to Rh are what type?
IgG
** CAN cross placenta –> erythroblastosis fetalis
F VIII deficiency?
hemophilia A
XLR
F IX deficiency?
hemophilia B
XLR
F XI deficiency?
hemophilia C
AR
what is thromboplastin?
same as tissue factor
converts VII –> VIIa
what does kallikrein do?
converts HMWK to bradykinin
what does bradykinin do?
causes vasodilation, vascular permeability, pain
what are the factor Xa anticoagulants?
LMWH (greatest efficacy)
heparin
direct: apixaban, rivaroxaban
fondaparinux
what are the factor IIa (thrombin) anticoagulants?
heparin (greatest efficacy)
LMWH
direct: argatroban, bivalirudin, dabigatran
what does aminocaproic acid do?
inhibits plasminogen –> plasmin
procoagulant
what enzyme does warfarin inhibit?
epoxide reductase (converts oxidized vit K to reduced vit K)
what activates protein C?
thrombin-thrombomodulin complex - found in endothelial cells
what does protein S do?
helps protein C inactivate Va, VIIIa
factor V leiden?
factor V that is resistant to inactivation by protein C
what does plasmin do?
cleavage of fibrin mesh
degradation of coagulation factors
antithrombin function?
inhibits activated: II, VII, IX, X, XI, XII
** main targets = thrombin and Xa
heparin MOA?
enhances antithrombin activity
what causes vasoconstriction after endothelial damage?
neural stimulation reflex
endothelin release from damaged cell
where does vWF come from?
Weibel Palade bodies of endothelial cells
alpha granules of platelets
where does vWF bind?
exposed collagen and GpIb on platelets
what does ADP do in platelet aggregation?
helps adhere to endothelium
induces GpIIb/IIIa expression
what does fibrinogen bind?
GpIIb/IIIa
what does ristocetin do?
activates vWF to bind GpIb
