Helminthic Infections Flashcards

1
Q

Major component of inflammatory response to helminths?

A
  • Eosinophils (contain basic toxic proteins)
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2
Q

Cylindrical organisms with tubular digestive tracts?

A
  • Roundworms (nematodes)
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3
Q

Dorsoventrally flattened organsims with digestive tracts that end in blind loops?

A
  • Flatworms (trematodes)
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4
Q

Segmented organisms with separate head and body parts lacking a digestive tract and absorb nutrients through outer walls?

A
  • Tapeworms (cestodes)
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5
Q

Inflammatory parasitic infection of lymph vessels cause by roundworms Wuchereria bancrofti and Brugia malayi?

A
  • Lymphatic filariasis
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6
Q

Lymphatic Filariasis

A
  • adult worms inhabit lymphatics in inguinal, epitrochlear, and axillary LNs, testis, epididymis
  • if obstruction, severe lymphedema
  • mosquito bites transmit infectious larvae that mature in LNs
  • most severe form = elephantiasis
  • worms are surrounded by inflammatory mediators
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7
Q

Chronic Inflammation of skin, eyes and lymph caused by filarial nematode O. volvulus?

A
  • Onchocerciasis - river blindness!
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8
Q

Oncocerciasis

A
  • transmitted by bites of blackflies
  • adult worms live as coiled tangled masses in deep fasciae and subcutaneous tissue and release millions of microfilariae which migrate
  • when migrate to all regions of the eye = blindness
  • microfilarie die and produce vigorous inflammatory response
  • can become encapsulated by fibrous scar and form nodules
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9
Q

Infection by filarial nematode Loa loa

A
  • Loiasis, African eyeworm
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10
Q

Loiasis

A
  • infection transmitted by mango flies
  • adult worms can migrate in skin and cross beneath conjunctiva
  • static worms surrounded by inflammatory cells
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11
Q

Most common helminthic infection of humans, large roundworm and usually asymptomatic?

A
  • Ascariasis, A. lumbricoides
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12
Q

Ascariasis

A
  • adult worms live in small intestine, penetrate bowel wall and reach lungs though venous circulation
  • after leaving pulmonary capillaries, enter alveoli to glottis and are swallowed to again reach small bowel
  • heavy infections can cause vomiting, malnutrition, and sometimes intestinal obstruction
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13
Q

Trichuris trichiura

A
  • Trichuriasis, intestinal nematode (whipworm)

- adult worms live in feces and upper colon and bury their anterior portion into the superficial mucosa

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14
Q

Hookworms

A
  • Necator americanus and Ancylostoma duodenale
  • intestinal nematodes, infect human small bowel
  • cause blood loss and anemia
  • most important cause of chronic anemia worldwide
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15
Q

Strongyloidiasis

A
  • small intestinal infection with nematode S. stercoralis (threadworm)
  • in immunocompromised, can progress to lethal disseminated disease
  • adult females bury in crypts of duodenum or jejunum, lay eggs that hatch quickly and release rhabditiform larvae
  • may reproduce in human hosts by autoinfection
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16
Q

Pinworm

A
  • Enterobiasis vermicularis, intestinal nematode
  • perianal itching
  • adult resides in cecum but migrates to perianal skin to deposit eggs
17
Q

Myositis associated with eating pork?

A

Trichinosis, from roundworm Trichinella spiralis

18
Q

Trichinosis

A
  • inadequately cooked meat with encysted T. spiralis larvae
  • larvae burrow into intestinal mucosa and develop into adult worms then enter circulation
  • can only survive in striated skeletal muscle and elicits an intense inflammatory infiltrate
  • in severe infections, eosinophilia can be extreme
19
Q

Infection of deep organs by visceral larva migrans, transmitted by cats and dogs?

A

Toxocariasis

20
Q

Toxocariasis

A
  • infection of deep organs by helminthic larvae

- larvae invade intestinal wall, are carried to liver, and die in tissues to form small granulomas

21
Q

Cutaneous larva migrans

A
  • larval nematodes migrating through skin and causing pruritis and serpiginous urticarial trails
22
Q

Dracunculiasis

A
  • guinea worm, features long adult worms beneath skin
  • transmitted in drinking water
  • reddish papule with anterior end of female worm underneath, which can burst forward and spew larvae in water
23
Q

Schistosomiasis

A
  • most important human helminthic disease (greater morbidity and mortality)
  • damage to the liver, intestine, or urinary bladder
  • alternate between asexual reproduction in snail and sexual reproduction in vertebrate host
  • S. mansoni and S. japonicum deposit eggs in intestinal venules
  • S. haematobium lays eggs in urinary bladder
  • cicumscribed granuloma or cellular infiltrate of eosinophils and neutrophils around an egg
  • progresses from granulomas to fibrosis
24
Q

Inhabits branches of IMV (affects distal colon, liver)

A

S. mansoni

25
Q

Inhabits veins of rectum, bladder, pelvic organs

A

S. haematobium

26
Q

Inhabits branches of SMV (affects small bowel, ascending colon, liver)

A

S. japonicum

27
Q

Infection of the hepatic biliary system by Chinese liver fluke

A
  • Clonorchiasis (Clonorchis sinensis)
28
Q

Clonorchiasis

A
  • sometimes associated with bile duct stones, cholangitis, and bile duct cancer
29
Q

Paragonimiasis

A
  • pulmonary infection by oriental lung fluke

- peripheral eosinophilia common

30
Q

Biliary disease acquired from sheep?

A

Fascioliasis (sheep liver fluke F. hepatica)

31
Q

Fascioliasis

A
  • hepatic abscesses and granulomas
32
Q

Fasciolopsiasis

A
  • F. buski

- attaches to duodenal or jejunal wall which may ulcerate

33
Q

Tapeworms

A
Taenia saginata (beef)
Taenia solium (pork) - cysticercosis - systemic
Diphullobothrium latum (fish)
Echinococcus granulosus (dog feces) - liver and lungs