Helicobacter Flashcards
this specie is previously classified under Campylobacter
Helicobacter
it is spiral, curved, rod shaped gram-negative
Helicobacter
this group of Helicobacter colonizes the stomach
Gastric helicobacter
This group of helicobacter colonizes the intestines, liver and biliary tract
Enterohepatic helicobacter
this Helicobacter spp. is highly motile (corkscrew motility)
Helicobacter pylori
it colonizes the stomach of 50%
of the world’s human population
H.pylori
H.pylori produces abundant urease that catalyzes urea hydrolysis to produce ammonia (True or False)
True
induces the formation of vacuoles in the cytoplasm
vacuolating cytotin (VaCa)
a pathogenicity island that encodes a type IV secretion system
syringe-like structure
cytotoxin-asociated Gene A (CagA
Lipopolysaccharide of H. pylori
(glycoprotein moiety) is identical to
the Lewis blood group antigen expressed on gastric parietal cells (True or False)
True
it predisposes to duodenal ulcers
Acute gastritits
it predisposes to adenocarcinoma of stomach
pangastritis
80% of duodenal ulcers & 60% of gastric ulcers
Peptic ulcer disease
lab diagnosis for helicobacter
invasive test
detects the presence of urease activity in gastric biopsies by using a broth
Biopsy urease test
Patient drinks a solution of urea labeled with the nonradioactive C and then blows into a tube. If H. pylori urease ispresent, the urea is hydrolyzed and labeled CO2 is detected in breath samples by mass spectroscopy.
urea breathe test
Most consistent and accurate test
urea breathe test
Used to monitor treatment response
Useful for screening of children.
stool antigen assay
Screening before endoscopy
Seroepidemiological study
antibody detection by ELISA
this Helicobacter spp. is from Humans and hamsters
H. cinaedi
