Heart Failure Flashcards
How can HF be classified?
Ejection fraction
Time
Left/Right
How do you measure ejection fraction?
Echocardiography
Reduced left ventricular ejection fraction is defines as < 35-40%
= HF-rEF
What % of patients with HF have HF-rEF?
50%
Remaining have HF-pEF
What causes HF-rEF?
Systolic dysfunction e.g. IHD Dilated cardiomyopathy Myocarditis Arrhythmias
What causes HF-pEF?
Diastolic dysfunction e.g. HOCM Restrictive cardiomyopathy Cardiac tamponade Constrictive pericarditis
How do we classify HF by time?
Acute - exacerbation
Chronic
How do we classify HF by side?
Left/Right
Typically lefy
What can cause left sided heart failure?
Increased ventricular afterload
e.g. arterial hypertension or aortic stenosis
Increased left ventricular preload
e.g. aortic regurgitation causing backflow
What can cause right sided heart failure?
Increased right ventricular afterload e.g.
Pulmonary HTN
Increased right ventricular preload
e.g. Tricuspid regurgitation
What are the symptoms of left-sided heart failure?
pulmonary oedema
- dyspnoea
- orthopnoea
- paroxysmal nocturnal dyspnoea
- bibasal fine crackles
What are the symptoms of right-sided heart failure?
peripheral oedema - ankle/sacral oedema raised jugular venous pressure hepatomegaly weight gain due to fluid retention anorexia ('cardiac cachexia')
What is high output HF?
situation where a ‘normal’ heart is unable to pump enough blood to meet the metabolic needs of the body
What are some causes of high output HF?
anaemia arteriovenous malformation Paget's disease Pregnancy thyrotoxicosis thiamine deficiency
What is AHF?
Acute HF
sudden onset or worsening of the symptoms of heart failure
Usually in pts >65
What usually causes AHF?
Reduced cardiac output that results from a functional or structural abnormality
What can cause de-novo AHF?
Increased cardiac filling pressures Myocardial dysfunction Usually both caused by ischaemia Decreased CO Hypoperfusion
What are the most common precipitating causes of AHF?
Acute coronary syndrome
Hypertensive crisis
Acute arrhythmia
Valvular disease
What are the symptoms of AHF and corresponding signs?
Breathlessness - Cyanosis
Reduced exercise tolerance - Tachycardia
Oedema - Raised JVP
Fatigue - displaced apex beat
S3 heart sound
Bibasal crachles +/- wheeze
What investigations are done for AHF?
Bloods - anaemia, electrolytes, infection
CXR - oedema, cardiomegaly
Echo - pericardial effusion and cardiac tamponade
BNP
What BNP levels indicates myocardial damage?
> 100mg/L
What is the treatment for HF?
IV loop diuretics e.g. furosemide
+/-
O2
Vasodilators e.g. nitrates
What is done for HF pts with resp failure?
CPAP
When should beta blockers be stopped inHF?
Brady
2nd/3rd degree heart block
Shock
What are the investigations for chronic HF?
BNP
hormone produced mainly by the left ventricular myocardium in response to strain
Gold-standars is echo
What factors increase BNP?
Left ventricular hypertrophy Ischaemia Tachycardia Right ventricular overload Hypoxaemia (including pulmonary embolism) GFR < 60 ml/min Sepsis COPD Diabetes Age > 70 Liver cirrhosis
What would decrease BNP?
Obesity Diuretics ACE inhibitors Beta-blockers Angiotensin 2 receptor blockers Aldosterone antagonists
What are the signs and symptoms of chronic HF?
Dyspnoea Cough - worse at night, pink frothy sputum Orthopneoa/Paroxysmal nocturnal dyspnoea Wheeze Weight loss - can be hidden by gain 2ry to oedema Bibasal crackles Raised JVP Ankle oedema S3 gallop
What is the first line treatment for chronic HF?
ACEi
Betablocker e.g. bisoprolol
Start one at a time
Does not work in HF-pEF
What is second line treatment for chronic HF?
Aldosterone anatagonist
e.g. spironolactone
What must be monitored in patients on ACEi and Aldosterone antagonsists?
Potassium
Can induce hyperkalaemia
What is myocarditis?
myocardial inflammation in the absence of predominant acute or chronic ischaemia
What are some key diagnostic features of myocarditis?
Prior viral infection
Autoimmune disease
Infectious disease
What are some presenting features of myocarditis?
Chest pain Dyspnoea Orthopnea Fatigue Palpitations S3 gallop
What would be seen on an ECG in myocarditis?
non-specific ST-segment and T-wave abnormalities