Heart anatomy Flashcards

1
Q

What is the coronary sulcus and what does it contain?

A

The coronary sulcus is also known as the atrioventricular sulcus and separates the atria from the ventricles.

In this groove one can find the right coronary artery, circumflex branch of left coronary artery, coronary sinus and the great cardiac vein.

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2
Q

What are the anterior interventricular sulcus and posterior interventricular sulcus? What do each contain?

A

Anterior interventricular sulcus - divides the ventricles on the anterior side
Contains: left anterior descending artery (branch of left coronary artery), great cardiac vein

Posterior interventricular sulcus - divides the ventricles on the posterior side
Contains: right posterior descending: posterior interventricular artery - brnach of right coronary artery, middle cardiac vein.

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3
Q

Describe the pulmonic, aortic, mitral and tricuspid valves

A

Pulmonic - right

  • has a left, right, and anterior flap
  • most anterior

Aortic - behind and left
-has a left right and posterior flip

——both of these valves have a semilunar nodule——–, these close up the little hole that would form from three convex shapes coming together

Mitral - posterior left, and only an anterior and posterior flap

Tricuspid - posterior right, an anterior and posterior flap and also a SEPTAL VALVE.

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4
Q

What is the normal auscultation points for aortic valve and pulmonic valve?
(listen downstream)

A

Aortic valve - between left ventricle and ascending aorta

  • 2nd intercostal space at the right sternal margin
  • above the heart and on the right, with no bone covering

Pulmonic valve - between right ventricle and pulmonic trunk
-2nd intercostal space at the left sternal margin

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5
Q

What is the normal auscultation points for the tricuspid and mitral valves?

A
Tricuspid valve (between right atrium and right ventricle) 
-downstream is right ventricle which is anterior wall of heart, that is covered by sternum so you have to go just left, at the 5th intercostal space. 
Mitral valve (between left atrium and left ventricle) 
-downstream is left ventricle which is also 5th intercostal space at the mid-clavicular line, 3&1/2 inches from sternum.
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6
Q

What would aortic stenosis and pulmonic stenosis sound like and where would you listen for it?

A

Aortic/ pulmonic stenosis - you would hear it when the outflow tracts are open which is during systolic.

AV valves would close, outflow tracts open (blood flows through - murmur) and then aortic valve closes (dub)

LUB - pshhh - DUB: systolic murmur

Aortic stenosis: Listen at where the aortic valve is which is on the right 2nd intercostal space.

Pulmonic stenosis: Listen at where the pulmonic valve is which is at the left 2nd intercostal space

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7
Q

What would aortic and pulmonic regurgitation sound like and where would you listen to it?

A

Regurgitation is heard after the valves close. They close during diastolic.

So LUB-DUB-pshhh

Aortic regurgitation: flowing from aorta to left ventricle - left ventricle is heard at left 5th subcostal space at the midclavicular line

Pulmonic regurgitation: flowing from pulmonary trunk to the right ventricle
-right ventricle is heard at the left 5th subcostal space at the sternal margin.

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8
Q

What would mitral and tricuspid stenosis sound like and where would you hear it?

A

Mitral and tricuspid stenosis murmur would be heard when the valves open.

They open during diastolic.

They open after the outflow tracts close (DUB)

LUB-DUB-pshhhh

Mitral stenosis - would be at the left ventricle so left 5th intercostal space at the midclavicular line

Tricuspid stenosis - would be at the right ventricle so left 5th intercostal space at the left sternal margin

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9
Q

What would mitral and tricuspid regurgitation sound like and where would you hear it?
unique postions;;;

A

Mitral and tricuspid regurgitation murmur would be heard when they close.

They close during systolic.

LUB -pshhh - DUB

Mitral regurgitation: blood would flow into the left atrium. Left atrium can be heard at the axilla.

Tricuspid regurgitation: blood would flow into the right atrium. Right atrium can be heard at the RIGHT 5th intercostal space at the sternal margin.

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10
Q

Describe the structure of the right atrium.

A

Three major things drain into the right atrium:
SVC, Coronary sinus, and IVC (including valves for all three)

It has a rough wall portion (pectinate muscle) and a smooth wall part. Formed by incorporation of the sinus venarum

-separation between pectinate and smooth is the crista terminalis.

The atrial septum separates right and left atrium.

The fossa ovalis (oval shaped depression with a sharp edged upper border (limbus),

Tricuspid valve leading to right ventricle.

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11
Q

What is the structure of the right ventricle (and describe prolapse)

A

The tricuspid valve is attached to papillary muscle via Chorda tendinae.

Its rough muscle portion is called the trabeculae carnae. The smooth muscle part is called the infundibulum.

There is also a septomarginal trabeculae (moderator band) which connects the right ventricle septum to the base of the papillary muscle)

Prolapse: blood forces the tricuspid valve open. If there was damaged papillary muscles that didn’t contract when the ventricle contracts or damaged chorda trabeculae, then the valve would rise, invert and open again during ventricular contraction, (leading to regurgitation)

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12
Q

Describe the structure of the left ventricle and left atrium.

A

The septum has two parts, a muscular portion and membranous portion.

The left atrium is only smooth wall and pulmonary veins drain into it.

For the mitral valve there is a posterior and anterior papillary muscles.

Each cusp is attached to more than one muscle and each papillary muscle is attached to more than one cusp.

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13
Q

Describe the aortic valve

A

Three members of the aortic valve (right, left, posterior).

There are aortic sinuses. When blood flows up the aortic sinus, it forces the valve open by pushing the cusps into the aortic sinuses.

During diastolic, the blood wants to come back but they fill the sinuses and prevents the backflow.

IN the right and left aortic sinuses are small openings, that lead to the right and left coronary arteries which supply the myocytes in the wall of heart via capillaries.

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14
Q

Describe the coronary arteries - including anastomoses

A

Lets begin with the right coronary artery as it begins its journey from the right side of the aorta.

It gives branches to the SA node and then the marginal artery which supplies only the right ventricle.

As it travels in the coronary sulcus it will wrap around behind the heart.

At the back of the heart, it will give off the posterior interventricular artery (aka posterior descending artery) ———-in right dominance——–

Form the left side of the aorta, comes off the left coronary artery which goes into the coronary sulcus and is called the circumflex artery.

The coronary artery branch descends in the anterior wall and is known as the anterior interventricular artery. (left descending artery) - most commonly occluded

LEFT AND RIGHT ANASTOMOSE at the posterior left side of the heart between the left circumflex and right coronary artery + the posterior interventricular artery and the anterior interventricular artery.

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15
Q

Describe the venous drainage of the heart itself.

A

Small middle (right) and great cardiac vein (left) all drain into the coronary sinus on the posterior wall of the heart between left atrium and left ventricle.

Anterior cardiac veins drain directly into the right atrium. (don’t use coronary sinus)

Least cardiac veins (drain directly into the chamber. (they go from the surface directly into underlying chamber)
*so some blood is going into the left chambers meaning blood is not purely oxygenated.

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16
Q

Describe the pericardium layers and the possible problem with that.

A

The visceral pericardium is directly fused with the surface of the heart.

Next is the pericardial cavity .

Then the parietal pericardium and then the fibrous pericardium (practically fused)

If fluid fills the pericardial space, it can lead to compression of the heart as the fibrous pericardium is rigid. (interfering with venous return)

Pericardiocentesis -get the fluid out of the pericardial cavity

17
Q

Describe contraction of the heart.

A

Cardiac muscle spontaneously depolarizes and repolarizes. Contraction rate is dictated by the smooth muscle itself and by the fastest muscle cells, since they are all interconnected with gap junctions. So when one contracts, they all contract.

SA node- contains special cardiac muscle cells which depolarize faster than any other cell, they are the pace maker. However you don’t want everything to just contract at once.

You have a fibrous skeleton which acts as an insulator between atrium and ventricle. So SA node only dictates atrium. However, the fibrous skeleton has a hole in it, Running through that is the AV bundle and at the top is the Atrioventricular node.

The only way to get depolarization into the bundle is through the AV node, and the signal propagates through the bundle slower than any other cardiac muscle.

Bundle fibers travel on the moderator band to reach the papillary fibers faster (short cut)

18
Q

What are the four kinds of innervation of the heart?

A

There are parasympathetics and sensory

As well as sympathetics and sensory.

Preganglionic parasympathetics: come from the vagus nerve which arises from the brain stem.

The postganglionic parasympathetic cell bodies are on cardiac plexus.

With it are sensory fibers whose cell bodies sit in the ganglion on the vagus just under the jugular foramen. It finds out current condition, heart rate, blood pressure, oxygen

Preganglionic sympathetics arise from the lateral horn and go up the sympathetic chain and synapse at the thoracolumbar levels or even in the cervical ganglia and descend down.

Sensory fibers follow the sympathetics back from the heart and cell bodies are in the dorsal root ganglion. It tells you if cells are ischemic, and gives you conscious information. Like angina - referred pain to chest or upper limb. Things you need to be conscious of.

19
Q

Which side is the higher pressure system in the heart?

A

The systemic side is a higher pressure than the pulmonary side.

20
Q

What occurs in response to blood volume expansion?

A

The atrial and ventricular myocytes have endocrine functions and they secrete hypotensive hormones which lower blood volume and pressure by promoting the excretion of salt and water by the kidneys (get rid of water)

For example, atrial myocytes secrete Atrial Natriuretic Peptide (ANP) from granules stored in their cytoplasm.

For example: ventricular myocytes secrete precursor B-type natriuretic peptide, proBNP. It is not stored in granules so its production must be upregulated. So BNP responds slower than ANP> The rate at which BNP rises is a good sign for congestive heart failure.

C-type promotes clearance of both.

21
Q

How does pressure and speed of flow, permeability, elasticity, amount of smooth muscle and total area change from

Large artery > medium sized > arteriole > capillary > venule > vein.

A

Pressure and speed of flow: slowly decreases, sharply drops at the capillary level and keeps falling

Permeability - highest in the capillaries

Elastic substance - drops at the arteriole and capillary levels, increases for the arteries and veins

Muscle - completely drops at the capillary muscle and stays gone

Total area covered - is highest at the capillary level and lowest for large artery.

22
Q

What are the three layers of an artery?

A

Tunica intima - endothelium, basement membrane, internal elastic membrane
*long axis is parallel to the direction of blood flow, 2 to 3 times as long as wide, all blood vessels have an tunica intima.

Tunica media - smooth muscle, external elastic membrane

Tunica adventitia - contains the vasorum and nervi vasorum.

  • relatively thin in arteries, thicker in veins
  • nervi vasorum form the perivascular plexus
23
Q

Describe large elastic, muscular, small and arteriole arteries.

A

Large elastic - example: aorta, common carotids, subclavian, iliacs

  • a large amount of elastic tissue in both intima and media
  • elastic lamina have holes to allow substances to diffuse from endothelial side to deeper layer of arterial wall
  • elastic tissue made by smooth muscle cells in the tunica media

Muscular and small arteries - radial, tibial, arteries to skeletal muscle

  • as arteries get smaller they have more and more smooth muscle and less elastic tissue in their tunica media
  • they have good temperature control, vasoconstriction and AV shunts to conserve heat, vasodilate to release it.
  • has the distinct frilled internal elastic lamina

Arterioles - just one or two layers of smooth muscle - small diameter relatively thick walls = high resistance, this causes drop in blood pressure reaching the capillaries.

24
Q

What is the function of arterial elasticity?

A

During ventricular contraction and distension of the wall due to increasing blood pressure, energy is stored in the elastic tissue.

During diastole: blood pressure and ventricular relaxation decreases the pressure in the arteries and that energy stored in the walls gets released and used for elastic recoil.

Reduced elasticity can cause changes in systolic and diastolic pressures.

25
Q

Describe capillaries and the three types

A

Incredibly dense in the heart and brain. Blood entering the capillary is regulated by the precapillary sphincter

  • simple tubes one endothelial cell thick, they have a thin wall for easy diffusion, and branch extensively
  • *pericytes are found along capillaries (stem cells)
  1. Continuous capillaries (continuous layer of endothelial cell), the least permeable of the three, has very tight junctions
  2. Fenestrated capillaries - gaps in the cells with some membrane
  3. Sinusoids - very wide and mthe most permeable ,
26
Q

Describe transport at the capillary level.

A
  1. Hydrostatic pressure forces plasma out of the capillaries and into the tissues. At the venous end of the capillaries, colloid osmotic pressure brings 90% of fluid back into capillaries. (10% go to lymphatics.
  2. For larger molecules that can’t diffuse out, there is transcytosis via pinocytotic vesicles which can occupy 1/3 the volume of an endothelial cell.
27
Q

describe veins and venules.

A

Venous blood flow is independent of blood pressure in the arteries, Instead muscular activity and valves inferior to the heart help propel blood back to the heart.
-veins have high capacitance, store blood. Venous walls are highly distensible.

Venules are the smallest they go, they are as permeable as capillaries. Leukocytes tend to leave (diapedesis) from venules.

Small and medium veins have one or two circular layers of smooth muscle and tunica adventita has mostly elastic tissue.

Large veins: The adventitia has bundles of smooth muscle, lacks internal elastic artery.
-large vein smooth muscle is often longitudinally arranged.

28
Q

Describe lymphatics

A

They collect 10% of the fluid not picked up by venous end of capillaries.

Their structure is similar to capillaries except their basement membrane is discontinuous or missing altogether. This is so large proteins or materials can enter the lymphatics

Lymphatic capillaries begin tissue vessels with one end closed.

Lymphatic capillaries > lymphatics > lymph nodes (filtration) > lymphatic trunks> venous system.

29
Q

What are the functions of endothelial cells?

7 functions

A
  1. Selective permeability barrier > controls what goes out into the tunica medai and beyond, intima and inner media need to be supplied by diffusion from lumenal blood.
  2. Endothelial cells have metabolize (activate or inactivate) materials before they gain access to adjacent tissue.
    - also contain acetylcholine esterase and monoamine oxidase.
  3. Synthesizes nitric oxide (a short lived vasodilator) by NO synthetase.
  4. interacts directly with smooth muscle at the myo-endothelial junction.
  5. Anticoagulant/coagulant: platelets don’t adhere to endothelial cells and they produce prostacyclin to inhibit platelet function. However when the EC layer is damaged, it produces von Willebrand’s factor which allows platelets to adhere and initiate coagulation.
  6. It also busts clots by secreting tPA (tissue plasminogen activator) which dissolves fibrin
  7. Leukocyte adhesion and migration, they pass through endothelium and recognzie selectins on the EC. Integrins on the surface help them migrate.

7.

30
Q

Describe angiogenesis

A

When O2 decreases, HIF-1 levels increase which generates proteases to dissolve the basement membrane. New vessels sprout from preexisting vessels