Hearing Flashcards

1
Q

What neurotransmitters are involved in the IH Cell synapses?

A

Glutamate from AMPA Receptors.

Synchronised release.

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2
Q

What neurotransmitters are involved in the OH Cell synapses?

A

ACh, CGRP, ATP, GABA

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3
Q

The characteristic frequency and position upon the basal membrane is….

A

Logarithmic.

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4
Q

What is the pathway from the spiral ganglion to the auditory cortex?

A

Spiral ganglion, ventral cochlear nucleus, superior olive, Inferior colliculus, MGN, Auditory cortex.

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5
Q

What is phase locking?

A

Low frequency, firing every time.

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6
Q

What is the volley principle?

A

Neurons can’t follow every sound wave. Response is phase locked but not every cycle.

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7
Q

What is tonotopy?

A

Systematic organisation.

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8
Q

At high frequency, sound waves can produce…?

A

A sound shadow.

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9
Q

Interaural time delay is produced at which frequency?

A

Low Frequency

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10
Q

Interaural intenstiy difference is produced at which frequency?

A

High frequency

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11
Q

What happens when two impulses reach the same neuron?

A

An AP is initiated in the superior olivary nucleus.

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12
Q

In a Type EI (inhibitory neuron), what is the order of the contralateral, both ears and ipsilateral on the binaural graph?

A

Contralateral is the highest, then both ears then ipsilateral.

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13
Q

Where is Broadmann’s area 41 located in the brain?

A

The temporal lobe, low frequency at the anterior end and higher frequency at the posterior end.

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14
Q

Electrocochleography does what?

A

Measures the compound action potentials at the round window. Used in humans.

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15
Q

What is a BAEP?

A

Brainstem Auditory Evoked Potential. It has a small voltage (1-2uV)

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16
Q

What is incomplete deafness a result of?

A

Loss of outer hair cells (50dB of hearing loss)

17
Q

What is complete deafness?

A

Loss of BOTH inner and outer hair cells. Hearing aids needed. Cochlea can’t respond.

18
Q

What happens with aminoglycoside ototoxicity?

A

High frequency hearing loss.
First row of OH cells lost until completely lost.
Can lose IH cells.

19
Q

What is noise trauma?

A

Can be temporary or permanent. Hair cells don’t regenerate. It’s not just about intensity but the duration also.

20
Q

What is glutamate excitotoxicity?

A

NOISE -> depolarisation (excessive) -> Glutamate -> swelling and disruption -> synapse can recover. Calcium influx can lead to apoptosis.

21
Q

Oxidative stress in the cochlea

A

Common factor is from hearing loss due to noise. Free radicals can damage DNA and trigger cell death.

22
Q

What is Presbyacusis?

A

The deafness with aging.