Healing & Repair

Question 1

What is the difference between regeneration and repair?

Answer 1

Regeneration - restoring infected tissue (Acute inflammation)

Repair - Repairing tissue (chronic inflammation)

Question 2

What is Regeneration?

Answer 2

replacement of current damaged cells with functional, differentiated cells

Question 3

What is repair?

Answer 3

Production of a fibrous scar and changes in tissue structure

Question 4

What are the cell types in regeneration & repair?

Answer 4

• Labile cells; Rapid regeneration/active state is cell division)
• Stable cells (conditional renewal cells); variable rates of regeneration
• Permanent cells; unable to divide/regenerate

Question 5

What are the 4 stages in healing?

Answer 5

1) Clotting & Coagulation
2) Inflammatory cell migration
3) Proliferative phase - fibroblast migration, formation granulation tissue & angiogenesis
4) Maturation phase - Tissue remodelling

Question 6

Whats the difference between primary & secondary intentions?

Answer 6

Primary intention - Small wound, rapid healing, minimal tissue loss

Secondary intention - Large wounds, scar formation, healing takes longer and greater tissue loss