Healing/Repair Flashcards
Labile tissues
Hematopoietic cells of bone marrow
Squamous epithelium of skin, oral cavity, cervix, vagina
Columnar epithelium of GI tract
Cells that continuously divide
Stable tissues
Kidney
Liver
Smooth muscle
Low to no replication(G0), but can enter G1 and replicate rapidly if required
Permanent tissues
Heart, neural tissue, skeletal muscle
Cells that don’t divide
Epidermal Growth Factor - what does it do?
Stimulates fibroblasts and keratinocytes to divide. Stimulates keratinocytes to migrate
TGFa - what does it do?
Stimulates proiferation of hepatocytes and other epithelial cells
VEGF - what does it do?
Endothelial cells
Angiogenesis, increased permeability
PDGF - what does it do?
Chemotactic, stimulates ECM protein synthesis
FGFs - what does it do?
Chemotactic, mitogenic for fibroblasts
TGFb- and what does it do?
Chemotactic for leukocytes, suppresses acute inflammation
Give two reasons why a scar would form
The injured tissue doesn’t reproduce (muscle, not neurons)
Which 3 nutrients are associated with improved wound healing?
Vitamin C
Copper
Zinc
What is the von Hippel Lindau gene, and how does it relate to VEGF?
It is a tumor suppressor gene that binds the transcription factor HIF1a, limiting VEGF expression. This checks angiogenesis.
How does von Hippel Lindau syndrome affect VEGF expression?
HIF1a is constitutively activated. Unchecked VEGF expression. This leads to more angiogenesis in the pigment epithelium of the eye as well as the kidney.
Which type of collagen is found in granulation tissue?
Collagen III
Which type of collagen is found in scar tissue?
Collagen I
