Healing and repair

Question 1

What are the stages after acute inflammation occurs?

Answer 1

Resolution
Suppuration>discharge of pus
Repair and organisation with discharge of pus
Fibrosis
Chronic inflammation

Question 2

What is healing?

Answer 2

Restitution with no or minimal defect

Question 3

When does repair occur?

Answer 3

Occurs where tissue loss has happened. It is healing by secondary intention.Often occurs by fibrosis formation where cells can not regenerate

Question 4

What are the stages of repair by fibrosis?

Answer 4

Angiogenesis- noe blood vessel formation
Migration and proliferation of fibroblasts
Deposition of exracellular matrix
Remodelling - maturation and organisation of finbrous tissue

Question 5

What are the local factors that influence wound healing?

Answer 5

Infection - delays healing
Mechanical factors - early motion delays healing
Foreign bodies
Size, locatio and type of wound - heal better if blood supply good

Question 6

Systemic factors which affect healing

Answer 6

Nutrition - good diet promotes healing
Metabloc status - healing worse in diabetic patients
Circulatory status - good blood supply is a prerequisite
Homones