Acute inflammation

Question 1

What maintains cell integrity?

Answer 1

DNA
Cell membrane
Energy production
Protein synthesis

Question 2

Mechanisms of nuclear DNA damage

Answer 2

Silent injury
DNA repair
Dividing cells more susceptible
Permanent cells more resistant
Onn-lethal DNA dmage may be inherited by daughter cells

Question 3

What is apoptosis?

Answer 3

Defence against inherited and damage= mediated by p53 protein

Question 4

Mechanisms to disrupt memebrane integrity

Answer 4

Ion pumps fail
Disruppt membrane
Alter lipids
Crosslink membrane proteins

Question 5

What are free radicals?

Answer 5

Are particularly superoxide which trigger a chain reaction leading to lipideroxidation.
-oxidants)Can be moped up by free radical scavengers 9anti=

Question 6

What predicts severity of tissue injury?

Answer 6

Duration
Nature 
Proportion of cells affected
Regenerative capacity
Topography

Question 7

Give examples of non–lethal injury

Answer 7

Hydropic change
Fatty change
Membrane shedding

Question 8

Types of cell death

Answer 8

Apoptosis

Necrosis

Question 9

What is apoptosis?

Answer 9

Individual cell deletion which can be a normal or pathological event. It is in inherent cellular property that can be activated or prevented by specific signals. Reduced apoptosis leads to cell accumulataion and increased poptosis leads to cell loss.

Question 10

What is necrosis?What are the patterns of necrosis?

Answer 10

Pathological cell death.
Patterns are:
Coagulative
Colliquative
Caseous
Gangrenous
Fibrinoid
Fat necrosis