HEADACHES Flashcards

1
Q

PAIN SENSITIVE CRANIAL STRUCTURES

1) skin, subcutaneous tissue, muscles, ___________ of the skull;

(2) the
delicate structures of the eye, ear, nasal cavities, and paranasal
sinuses;

(3) ___________ because they are intradural

A

extracranial
arteries, and external periosteum

intracranial venous sinuses and their
large tributaries

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2
Q

(4) parts of
the dura at the ______________
the dura, particularly the ________________ and the intracranial segment
of the internal carotid artery; (5) the middle meningeal
and __________; and (6) the first three
cervical nerves and cranial nerves as they pass through
the dura.

A

base of the brain and the arteries within

proximal parts of the anterior
and middle cerebral arteries

superficial temporal arteries

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3
Q

Much of the __________________ and choroid plexuses lack sensitivity.

A

pia-arachnoid, the parenchyma of the brain,

and the ependyma

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4
Q

Pain that arises from distention of the

middle meningeal artery is projected to the __________

A

back of the

eye and temporal area.

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5
Q

Pain from the intracranial segment
of the internal carotid artery and proximal parts
of the middle and anterior cerebral arteries is felt in the
_______

A

eye and orbitotemporal regions.

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6
Q

The sphenopalatine branches of the facial

nerve convey impulses from the _______

A

nasoorbital region

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7
Q

The
ninth and tenth cranial nerves and the first three cervical
nerves transmit impulses from the ___________

A

inferior surface of

the tentorium and all of the posterior fossa.

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8
Q

To summarize, pain from supratentorial structures
is referred to the anterior two-thirds of the head, i.e., to
the territory of sensory supply of the_______________;

pain from infratentorial
structures is referred to the vertex and back of the head
and neck predominantly by the__________

A

first and second
divisions of the trigeminal nerve

second cervical roots.

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9
Q

The _____________
cranial nerves refer pain to the nasoorbital region, ear,
and throat

A

seventh, ninth, and tenth

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10
Q

Dental or temporomandibular

joint pain impulses are carried by the _____________

A

second and third

divisions of the trigeminal nerve

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11
Q

most patients with high intracranial pressure complain
of _____________ headaches that fluctuate in
severity, probably because of traction on vessels or dura.

A

bioccipital and bifrontal

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12
Q

The headaches that
follow seizures and ingestion of alcohol are probably all
caused by _________

A

cerebral vasodilatation.

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13
Q

increased _____________activates pain-sensitive structures

within their walls or around the base of the brain

A

pulsation

of meningeal vessels

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14
Q

A similar mechanism may be operative in the severe,
bilateral, throbbing headaches associated with ________________in blood pressure, as occurs with pheochromocytoma,
malignant hypertension, sexual activity, and
in patients being treated with monoamine oxidase inhibitors.

A

extremely

rapid rises

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15
Q

Activation of the
_______________ (the trigeminal nerves and the
blood vessels they supply), leading to an inflammatory
response that is generated by local neural mechanisms,
_______________” has also been assigned a role
in migraine headache.

A

trigeminovascular system

“neurogenic inflammation,

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16
Q

With regard to cerebrovascular diseases causing
head pain, the ______ AND ____________
when involved in giant cell arteritis (cranial or “temporal”
arteritis), give rise to severe, persistent headache,
at first localized on the scalp and then more diffuse

A

extracranial temporal and occipital arteries,

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17
Q

basilar artery thrombosis causes pain

to be projected to the _______

A

occiput and sometimes to the forehead;

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18
Q

Expanding or ruptured
intracranial aneurysms of the _________________ very often cause pain
projected to the eye.

A

posterior communicating

or distal internal carotid arteries

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19
Q

Infection or blockage of paranasal sinuses is accompanied by pain over the affected_____________

Usually it is associated with tenderness of the skin and
cranium in the same distribution

A

maxillary or frontal sinuses.

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20
Q

With _________, the pain tends
to be worse on awakening and gradually subsides when the patient is upright;

the opposite pertains with __________sinusitis

pain is ascribed
to __________ and its relief to their emptying,
induced by the dependent position of the ostia.

A

frontal and ethmoidal sinusitis

maxillary and sphenoidal

filling of the sinuses

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21
Q

When
_________ causes headache, the sclera
is invariably red.

Dilating the pupil risks precipitating
IT, a situation that can be reversed
by the administration of __________

A

acute angle closure glaucoma

pilocarpine 1 percent drops

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22
Q

Headaches that accompany disease of ligaments, m uscles,
and apophysial joints in the upper part of the cervical spine
are referred to the ______________on the
same side and sometimes to the__________

A

occiput and nape of the neck

temple and forehead.

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23
Q

The pain
of _____________ a controversial entity, is characterized
by tender areas near the cranial insertion of cervical and
other muscles.

A

fibromyalgia,

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24
Q

The______________(usually due to
infection or hemorrhage) is typically acute in onset, usually
severe, generalized, deep seated, constant, and associated
with stiffness of the neck, particularly on forward
bending.

A

headache of meningeal irritation

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25
dilatation and inflammation of meningeal vessels and the chemical irritation of pain receptors in the large vessels and meninges by endogenous chemical agents, particularly _________________, are probably more important factors in the production of pain and spasm of the neck extensors
serotonin and plasma kinins
26
__________________characterized by a steady occipitonuchal and frontal pain coming on within a few minutes after arising from a recumbent position (orthostatic headache) and is relieved within a minute or two by lying down. Its cause is a persistent leakage of CSF into the lumbar tissues through the needle track installation of an _____________relieves the headache.
Lumbar puncture (LP) or spontaneous low CSF pressure headache epidural "blood patch"
27
___________ headache may follow a cough, sneeze, strain, or athletic injury, sometimes as a result of rupture of the arachnoid sleeve along a nerve root
"Spontaneous" lowpressure
28
The headache of ____________ when it occurs, is dull and unilateral, perceived over most of the affected side of the head
subdural hematoma,
29
The ratio of classic to common | migraine is _____________.
1 :5
30
Migraine with aura is ushered in by a disturbance of nervous function, most often ________ followed in a few minutes to hours by hemicrania! (or, in about one-third of cases, bilateral) headache, nausea, and sometimes vomiting, all of which last for hours or as long as a day or more
visual,
31
The __________ and the ___________aspects of migraine are its most characteristic features in comparison to other headache types.
hemicrania throbbing (pulsating)
32
Migraine may have its onset in childhood but usually begins in adolescence or young adulthood; in more than 80 percent of patients, the onset is before _________ years of age,
30
33
Migraine tends to cease during the second and third trimesters of pregnancy in ________ percent of women,
75 to 80
34
Although migraine commonly diminishes in severity and frequency with age, it may actually ____________ in some postmenopausal women, and ______ therapy may either increase or, paradoxically, diminish the incidence of headaches
worsen estrogen
35
Migraine with aura frequently has its onset soon | ________, but it may occur at any time of day
after awakening
36
The visual or neurologic symptoms usually last for | less than ______
30 min, sometimes longer.
37
a migrainous personality | existed, characterized by _____________
tenseness, rigidity of | attitudes and thinking, meticulousness, and perfectionism
38
There may be associated vertigo, staggering, incoordination of the limbs, dysarthria, and tingling in both hands and feet, and sometimes around both sides of the mouth. These symptoms last 10 to 30 min and are followed by headache, which is usually occipital Exceptionally; there is an alarming period of coma or quadriplegia
basilar migraine
39
recurrent unilateral headaches associated with weakness of extraocular muscles. A transient third-nerve palsy with ptosis, with or without involvement of the pupil, is the usual picture; rarely, the sixth nerve is affected The ocular paresis often outlasts the headache by days or weeks; after many attacks, a slight mydriasis and, rarely, ophthalmoparesis may remain permanently.
O p ht h a l m o p l e g i c a n d Reti n a l M i g ra i n e
40
_______ of almost any degree may precipitate a migraine headache in persons prone to the condition Although a family history of migraine is frequent in such cases, there has been no history of hemiplegia in other family members.
Cranial trauma
41
Migraine symptoms in young children
Instead of complailling of headache, the child appears | limp and pale and complains of abdominal pain
42
a condition mostly of infants and children (rarely adults), there are episodes of unilateral paralysis that may long outlast the headache. mutation for familial hemiplegic migraine A second locus is in the gene for the Na+/K+-adenosine triphosphatase (ATPase) channel and a rarer subtype is caused by mutations in a sodium channel a.-subunit gene, _________
hemiplegic migraine the most common one is in the gene coding for the P /Q-type calcium channel a. subunit (CACNAlA). SCNA1
43
Indeed, there are shared traits between some of the genetic forms of familial hemiplegic migraine and both _________________
episodic and degenerative cerebellar diseases
44
Rarely, migrainous neurologic symptoms, instead of being transitory, leave a prolonged or even permanent deficit (e.g., homonymous hemianopia), indicative of an ischemic stroke. This has been called ________and a small number of these prove to be __________.
complicated migraine migrainous infarctions
45
_______________________________________(on rather uncertain grounds) in the pathogenesis of arterial occlusion and strokes that complicate migraine
Platelet aggregation, edema of the arterial wall, increased coagulability, dehydration from vomiting, and intense, prolonged spasms of vessels have all been implicated
46
In children and young adults with the _____________and in adults with the rare cerebral vasculopathy ___________________________ migraine may be a prominent feature
mitochondrial disease MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy),
47
_____________ has been especially associated with | an open foramen
Migraine with aura
48
migraine that lapses into a condition of daily or virtually severe continuous headache _________
(status migrainosus).
49
One-quarter of this group had a history of past migraine and a similar number had a viral-like illness within 3 weeks of the neurologic problem. The CSF contained from 10 to 760 lymphocytes per cubic millimeter, and the total protein was elevated. The transient neurologic deficits were mainly sensorimotor and aphasic; only 6 patients had visual symptoms. The patients were asymptomatic between attacks and in none did the entire illness persist beyond 7 weeks
Headache with Neurological Deficits | and CSF Lymphocytosis
50
MIGRAINE PATHOPHYSIO In reference to the extracranial vessels, Iversen and associates, by means of ultrasonography, documented a ___________ on the side of the migraine during the headache period. there is frequently a reduction in__________ during an aura. innervation of extracranial and intracranial vessels by small unmyelinated fibers of the trigeminal nerve that subserve both pain and autonomic functions _______________
dilatation of the superior temporal artery posterior cortical blood flow (the "trigeminovascular" complex).
51
Activation of the TRIGEMINOVASCULAR SYSTEM releases __________ and other peptides into the vessel wall, which serves to sensitize the trigeminal system to the pulsatility of cranial vessels, and to increase their permeability; thereby promoting an i__________
substance P, calcitonin gene-related peptide (CGRP), Inflammatory response
52
the trigeminal pathways are in a state of ____________ in the migraine patient and that they discharge periodically, perhaps in response to hypothalamic stimulus acting on the endogenous pain control pathways
persistent hyperexcitability
53
Patients with waning visual auras should be advised to wait to self-administer ____________ until the headache begins _______ are ineffective in preventing headache if given during the aura
subcutaneous serotorun agoNISts triptans
54
the slower acting nasal spray or oral formulations are often ineffective if given too long after the start of headache and patients have learned to administer them _____________ and, again, this seems safe.
during the aura
55
A single____________ or its equivalent, given subcutaneously, is an effective and well-tolerated treatment for migraine attacks
6-mg dose of sumatriptan
56
Sumatriptan is available as a nasal spray, which is useful in patients with nausea and vomiting. The response rate after ___________
2 h is similar to that of the | orally a
57
_______ is an equally effective agent, but its peripheral and coronary vasoconstricting side effects have reduced its use. This is an______________ with strong serotorun receptor affinity and vasoconstrictive action. The drug is taken as an uncoated ________________, held under the tongue until dissolved (or swallowed), or in combination with caffeine
Ergotamine alpha-adrenergic agonist 1- to 2-mg tablet of ergotarnille tartrate
58
A single oral dose of ___________ or of metoclopramide 20 mg, given with the ergotarnille, relaxes the patient and allays the potential nausea and vomiting from ergotamine
promethazine 50 mg,
59
___________is thought, on slim evidence, to potentiate the effects of ergotamine and other medications for migraine
Caffeine, 100 mg,
60
____________ are generally avoided if there is an ongoing and prolonged aura of any type, including visual, but particularly with hemiparesis, aphasia, or features such as vertigo, drowsiness, or diplopia, referable to the basilar artery
serotorun agonists and ergots
61
___________ are contraindicated in symptomatic and asymptomatic coronary artery disease and poorly controlled hypertension.
Ergot drugs and triptans
62
The sympathomimetic drug _________ combined with a sedative, and __________(Midrin) has been useful for some patients and probably acts in a similar way to ergotamine and sumatriptan.
isometheptene acetaminophen
63
_____________have been found anecdotally to be useful in refractory cases and as a means of terminating migraine status, but they should not be given continuously
Intravenous and oral corticosteroids
64
approximately ____________ were appropriate for some form of prophylactic treatment on the basis of the frequency and severity of their headaches, usually more than one severe episode per week
one-fourth of patients
65
migraine prophylaxis Considerable success has been obtained with __________ beginning with_____________and increasing the dosage gradually to as much as 240 mg daily; probably best given as a long-acting preparation in the higher dosage range
propranolol 10 to 20 mg two to three times daily
66
migraine prophylaxis In patients who do not respond to these drugs over a period of 4 to 6 weeks, _________taken three to four times daily, other antiepileptic drug such as __________
valproic acid 250 mg topiramate, or amitriptyline, 25 to 125 mg nightly may be tried
67
__________ as already mentioned; ____________; and _______________, 4 to 16 mg/nightly are found to be helpful in some patients and may be particularly useful in preventing predictable attacks of perimenstrual migraine.
Isometheptene (Midrin) indomethacin, 150 to 200 mg /d cyproheptadine (Periactin)
68
The newest putative treatment for chronic or frequently repeating headaches, both migraine and tension, is the injection of ______________and other cranial
``` Botulinum toxin (Botox) into sensitive temporalis ```
69
__________ an ergot derivative that was more widely used in the past, in doses of 2 to 6 mg daily for several weeks or months is effective in the prevention of migraine. ____________are rare but serious complications that can be avoided by discontinuing the medication for 3 to 4 weeks after every 5-month course of treatment
Methysergide (Sansert), Retroperitoneal and pulmonary fibrosis
70
example of Indomethacine responsive HA
These include orgasmic migraine, chronic paroxysmal hemicrania (see further on), hemicrania continua, exertional headache, hypnic headache, brief head pains (jabs and jolts and "icepick" headaches), and some instances of premenstrual migraine.
71
Other names for cluster:
paroxysmal nocturnal cephalalgia, migrainous neuralgia, histamine cephalalgia (Horton's headache), and others.
72
Cluster HA This headache pattern occurs predominantly in adult men (age range: 20 to 50 years; maleto- female ratio approximately 5 : 1 ) and is characterized by a _________
severe consistent unilateral orbital localization
73
Cluster HA Its denominative feature is the ___________, or several times during the night for several or more consecutive days;
nightly recurrence, between 1 and 2 h after the onset of sleep
74
Cluster HA The headache has been called the _______ because it may recur with remarkable regularity each night for periods extending as long as many weeks, followed thereafter by complete freedom for many months or even years.
"alarm clock headache"
75
cluster HA There are several associated vasomotor phenomena by which cluster headache can be identified: ____________________, all lasting on average for 45 min (range: 15 to 180 min).
a blocked nostril, rhinorrhea, injected conjunctivum, lacrimation, miosis, and a flush and edema of the cheek
76
A somewhat similar syndrome as cluster HA is produced by the ________ of eye pain and ocular motor paralysis
Tolosa-Hunt syndrome
77
Cases of paroxysmal pain behind the eye or nose or in the upper jaw or temple-associated with blocking of the nostril or lacrimation and described in the past under the titles of _________________ (Charlin or Harris)-probably represent variants of cluster headache.
sphenopalatine (Sluder), petrosal, vidian, and ciliary | neuralgia
78
These are of much shorter duration (2 to 45 min) than cluster and usually affect the temporoorbital region of one side, accompanied by conjunctival hyperemia, rhinorrhea, and in some cases a partial Homer syndrome. respond dramatically to the administration of ________
Chronic paroxysmal hemicrania indomethacin, 25 to 50 mg tid.
79
similar to paroxysmal hemicrania in which the supraorbital or temporal pain lasts up to 4 min or so and frequent; it does not usually respond to indomethacin
SUNCT (short-lasting unilateral neuralgiform | attacks with conjunctival injection and tearing)
80
flushing of the face on the side of a ________ and pallor in _________; increased intraocular pressure in __________, normal pressure in________; increased skin temperature over the forehead, temple, and cheek in cluster headache, decreased temperature in migraine
cluster headache, migraine cluster headache, migraine
81
Cluster may be triggered in sensitive patients by | the use of _______ and, as mentioned, by alcohol.
nitroglycerin
82
mechanism of cluster paroxysmal parasympathetic discharge mediated through the _______ and ________ pain arises from the __________, in the canal through which it ascends in the _________
greater superficial petrosal nerve and sphenopalatine ganglion internal carotid artery petrous portion of the temporal bone
83
The cyclic nature of the attacks has been linked to a hypothalamic mechanism that governs the circadian rhythm. At the onset of the headache, the region of the _________ appears to be active on PET
suprachiasmatic nucleus
84
_____________has also been found in migraine, SUNCT, chronic paroxysmal hemicrania, and hemicrania continua
Hypothalamic activation
85
treatment of cluster
Inhalation o f 100 percent oxygen via mask for 1 0 to 1 5 min at the onset of cluster headache may abort the attack, but this is not always practical
86
Termination of a cycle of cluster can also be achieved with ____________ but __________monitoring is recommended in the older individual.
verapamil, starting with 80 mg qid and increasing the dose over days, electrocardiogram (ECG)
87
The usual nocturnal attacks of cluster headache can be treated with a single anticipatory dose of ______________) or with possibly lesser efficacy; an equivalent dose of serotonin agonist
ergotamine at bedtime (2 mg orally
88
prevention of cluster
verapamil, up to 480 mg per day
89
prevention of cluster A course of _________ and then reducing the dose at 3-day intervals, has been beneficial in many patients
prednisone, beginning with 75 mg daily | for 3 days
90
This, said to be the most common variety of headache, is usually bilateral, with occipitonuchal, temporal, or frontal predominance, or diffuse extension over the top of the cranium
Tension Headache
91
In a substantial group of patients with chronic daily headache, the pain, when severe, develops a pulsating quality, to which the term _________ has been applied
tension-migraine or tensionvascular headache
92
______________are hardened in patients | with tension headaches
pericranial | and trapezius muscles
93
a headache syndrome in older patients that shares with cluster headache a nocturnal occurrence _______ successfully treated a number of his patients with________________ at bedtime
(hypnic headache). 300 mg of lithium carbonate or 75 mg of sustained-release indomethacin
94
The most common cause of generalized persistent headache, both in adolescents and adults, is probably mild ____________ in one of its several forms
depression or anxiety
95
Odd cephalic pains, e.g., a sensation of having a nail driven into the head____________ may occur in hysteria or psychosis and raise perplexing problems in diagnosis.
(clavus hystericus),
96
the patient develops an increasingly intense throbbing or nonthrobbing headache, often with superimposed sharp, stabbing pains. The _____________ and other scalp arteries are frequently thickened and tender and without pulsation.
Headaches of Tem pora l Arteritis ( G i a nt Cel l Arteritis) superficial temporal
97
In GCA, ________ and _________ on the scalp, with ulceration of the overlying skin, have been described in severe cases
Jaw claudication and ischemic nodules
98
Usually the sedimentation rate is greatly elevated (>50 mm/h and typically >75 mm/h) but elevation of the ___________ level is a more sensitive indicator of this inflammatory condition and is particularly helpful when the sedimentation rate is only mildly elevated
C-reactive | protein (CRP)
99
in GCA, The importance o f early diagnosis relates t o the threat of blindness from thrombosis of the _______ and _________
ophthalmic | or posterior ciliary arteries
100
treatment of GCA
The administration o f prednisone, 4 5 t o 6 0 mg/ d in single or divided doses over a period of several weeks, is indicated in all cases, with gradual reduction to 10 to 20 mg /d and maintenance at this dosage for several months or years, if necessary, to prevent relapse
101
Most typical is a feeling of _________that is greatly worsened by lying down some of them respond to medications such as ___________ compounds
occipital pressure propranolol and ergot
102
mechanism of catamenial HA
The relation of headache to a drop in estradiol levels during the late luteal phase
103
Premenstrual headache, taking the form of migraine or a combined tension-migraine headache, usually responds to the administration of an NSAID begun ___________before the anticipated onset of the menstrual period; ``` oral sumatriptan (25 to 50 mg qid) and zolmitriptan (2.5 to 5 mg bid) are also equally effective ```
3 days
104
It can be stated that _________ may be used safely in the small proportion of women whose headaches persist or intensify during pregnancy.
beta-adrenergic compounds and tricyclic antidepressants
105
As a rule, it follows the initiating action within a second or two and lasts a few seconds to a few minutes.Most often this syndrome is a benign idiopathic state that recurs over a period of several months to a year or two and then disappears. ______ is usually effective in controlling exertional headaches; this has been confirmed in controlled trials
Cou g h and Exertio n a l H eadache Indomethacin
106
In cases of repeated coital headache, _________ has | been effective
indomethacin
107
Thunderclap headache, as pointed | out by Dodick, has also been a symptom of________
pituitary apoplexy, cerebral venous thrombosis, cervical arterial dissection, non-aneurysmal perimesencephalic hemorrhage, or hypertensive crisis
108
An intense, generalized, throbbing headache may occur in conjunction with flushing of the face and hands and numbness of the fingers (erythromelalgia). Episodes tend to be present on awakening from sound sleep
E ryth rocya n otic Headache
109
paroxysms of intense, stabbing pain in the distribution of the mandibular and maxillary divisions (rarely the ophthalmic division) of the fifth cranial nerve
Trigem i n a l Neura l g i a (Tic D o u l o u reux
110
It has also become apparent that a proportion of ostensibly idiopathic cases are caused by compression of the trigeminal roots by a__________________
small tortuous branch of the basilar artery;
111
in TN, Carbamazepine is effective in _______ percent of patients, but half become tolerant over a period of several years
70 to 80
112
In TN, _________ were relieved of pain by repositioning a small branch of the basilar artery that was found to compress the fifth nerve, and this benefit persisted with a recurrence rate of less than 1 percent annually for 10 years.
70 percent
113
A procedure used more in the past for TN, was ____________
stereotactically controlled thermocoagulation of the trigeminal roots
114
The pain is intense and paroxysmal; it originates in the throat, approximately in the tonsillar fossa, and is provoked most commonly by swallowing but also by talking, chewing, yawning, laughing, etc.
G losso p h a ryngeal N e u ra l g i a
115
be accompanied by bradycardia and even by syncope, presumably because of the triggering of cardioinhibitory reflexes by afferent vagal pain impulses. There is no demonstrable sensory or motor deficit
vagoglossopharyngeal | neuralgia.
116
Tx for vagoglossopharyngeal | neuralgia.
the conventional surgical procedure had been to interrupt the glossopharyngeal nerve and upper rootlets of the vagus nerve near the medulla but recent observations suggest that a vascular decompression procedure similar to the one used for tic and directed to a small vascular loop under the ninth nerve
117
Neuralgia associated with a vesicular eruption caused by the herpes zoster virus may affect cranial as well as peripheral nerves
Acute Herpes Zoster a n d Postherpetic | N e u ra l g i a
118
in herpes zoster,_________ during the early acute phase | may prevent persistent pain
amitriptyline
119
It is commonly the incipient symptom of Bell's palsy but there are a number of different causes and mechanisms
Ota l g i a
120
Paroxysmal pain may occasionally occur i n the distribution of the greater or lesser occipital nerves (suboccipital, occipital, and posterior parietal areas ) .
Occipita l N e u ra l g i a
121
In occipital neuralgia, The finding of hypesthesia in the distribution of the occipital nerves makes the possibility of an _________ more convincing
entrapment | neuropathy
122
This condition, a unilateral occipital and suboccipital | ache, may be a prominent symptom in patients with neck pain, particularly after neck injuries
"Third Occi pita l Nerve" Headache
123
degenerative or traumatic arthropathy involving the C2 and C3 apophysial joints with impingement on the "third occipital nerve" __________________
(a branch of the C3 dorsal ramus that crosses the dorsolateral aspect of the apophysial [facet] joint) .
124
special type of cervicofacial pain that could be elicited by pressure on the common carotid arteries of patients with atypical facial neuralgia.
Ca rotidyn i a a n d Extracra n i a l Artery | Dissection