Headaches! Flashcards

1
Q

What are Primary Headaches?

A

HA without intracranial Pathology (like tumors etc)

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2
Q

Definition of Migraine and Pattern for Migraine

3 Types of Migraine:

A

Migraine = HA + Autonomic symptoms; often associated with depression, anxiety, insomnia etc

Pattern = Acute and Recurrent, severe, unilateral or bilateral, relieved with sleep, pulsating pain, can have photophobia and phonophobia and nausea

Migraine with Aura

Migraine without Aura

Complicated Migraine

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3
Q

What is cutaneous allodynia?

A

Skin hurts when its not supposed to!!!

Means that pain/headache has gone from easily treatable peripheral condition to hard to treat central condition

RACE against the clock to prevent this!

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4
Q

Criteria for migraine without aura?

A

2 of the following:

  • unilateral
  • pulsating pain
  • nausea
  • photophobia/phonophobia

BOTH of the following:

  • similar pain in past
  • no organic disease
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5
Q

What is a complicated migraine?

A

Migraine with the following:

  • Hemiplegic - neuro findings of weakness etc

Opthalmoplegic - double vision

Basilar Artery Migraine - problems with balance, almost like a stroke

Alice in Wonderland - perceive things as big/small

*TRYPTANS CONTRAINDICATED IN COMPLICATED MIGRAINES

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6
Q

What is a tension-type HA?

A

Often bilateral

Squeezing pain - worse as day goes on

Less severe than migraine

*NO AUTONOMIC SYMPTOMS

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7
Q

Causes of Secondary HA?

A

Tumor

HTN

Infection

Acute hemorrhage (like Sub-Arachnoid Hemorrhage)

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8
Q

Pattern for secondary HA from Tumor

A

Chronic Progressive pain

**worse in morning (ICP increased) **

**Exacerbated by valsalva **

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9
Q

HTN as a cause of secondary HA?

Features? Causes?

A

Rare, if real think brain, kidney, thyroid, drugs or tumors secreting vasoactive substances to cause it

–> usually secondary to pain

*Malignant HTN can lead to dysregulation of BBB and cause HA (but little increase in BP not going to cause HA)

**Primary Intracranial HTN = Pseudotumor **

  • can cause tumor pattern (chronic progressive pain worse in AM)
  • Papilloedema!
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10
Q

Presentation of Acute Hemorrhage?

A

Thunderclap HA usually from a slow vessel leak that then bursts (aneurysm in head that blows - can kill you!!)

Neck stiffness - blood in neck

Low fever

GET a CT (bc fast) and then LP which can also help relieve pressure

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11
Q

Other secondary causes of HA?

A

Sinusitis

TMJ

Primary Intracranial HTN

Chiari Malformation - cerebellar herniation that occludes spinal canal but rarely causes HA and more likely causes intermitten neurological hands/feet symptoms

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12
Q

Red Flags for secondary HA?

A

SNOOP

Systemic symptoms - weight loss, stop mensturating

Neuro symptoms

Onset - rapid or chronic

Older - (pts >40)

Previous HA history is different

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13
Q

Whta is Chronic Daily HA and how does it present?

A

>15 HA /month and >4 hours a day

Get adjunct symptoms from having HA all the time: Anxiety, depression, insomnia

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14
Q

Type of Chronic Daily HA and Presentations?

A

Transformed Migraine - Migraines that occur closer and closer together; harder to prevent spike/onset of migraine bc already have baseline of HA symptoms

Chronic Tension-Type HA = HA moving closer and closer togeter, same pattern but no migraine spikes bc never had them in the first place

New Persistent Daily HA - new chronic HA without history of TT or migraine - BAD

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15
Q

Physiology of HA?

A

Genetic Predisopsition + Stimulus (internal - stress or external - light) lower thresholds for HA

*Decreased serotonin in Medium Dorso Raphenucleus and Trigeminovascular System opens the 5Ht1-D receptor gate and allows inflammatory cytokine soup to be released from brain - PG, Histamines, Subs P

Meninges get inflamed = HA

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16
Q

STrategy for Medicine?

A

STRATIFIED CARE

17
Q

Acute HA treatment regimes?

rescue Meds?

A

PG inhibiters and Antihistamines - work on the soup that’s there

5-HT agonists = Triptans - help to close gate and stop acute mediators of inflammation and put 5-HT back to close the gate

Adjuncts: Antiemetics and anxiolytics

Rescue Meds (once cutaneous allodynia has already happened)

  • DHE, Opioids, Reglan, Odansentron (antiemetic, serotonin antag)
18
Q

What are the different triptans?

A

Sumatriptan - quick in and out

Zolmitriptan - good tastes, easy to administer

Rizatriptan - need for GI absorption, placebo?

Naratriptan - Long acting - good for recurrence problems and used for **Menstrual migraines **

Dihydroergoatamine (IV) -DHE different mechanism and can be used as rescue

19
Q

Drugs for prevention of mirgrains?

A

Amitriptyline - TCA, SNRI anti-depressant also can be used for chronic or neuropathic pain

Cyproheptadine - antihistamine that increases hunger

Divalproex sodium - Anticonvulsant

Gapapentig - Anticonvulsant, analgesic, used for neuropathic pain

Topiramate - anticonvulsant, decreases hunger….makes you skinny!

Propanolol - lowers BP

Verapamil - CCB