Headache Medicine Flashcards
PrimaryHeadache Disorders
Migraine
Tension-type
Trigeminal autonomic cephalalgia
Other
What is Migraine?
A heritable syndrome with attacks including light and
noise sensitivity, nausea, disequilibrium, gastrointestinal dysfunction, and headache
12-14% experienced
women 3x more than men
Premonitory symptoms
Hours to days
Fatigue
Mood changes
Food cravings
Yawning
Muscle tenderness
Photophobia
Aura
5-60 minutes
Throbbing pain
Nausea
Photophobia
Phonophobia
Osmophobia
Postdrome
24-48 hours
Fatigue
Cognitive changes
Neck stiffness
Nociceptive neurons that innervate the ___ are believed to release _____
dura
vasoactive neuropeptides (e.g., CGRP, PACAP) causing signaling along the trigemino-vascular pathway.
Over time, neurons in this pathway are believed to become sensitized. That is, their threshold for response decreases and the magnitude of their response increases.
Some believe the CSD wave traveling across the brain causes release of ATP, glutamate, potassium, hydrogen ions, CGRP, nitrous oxide that diffuse toward the surface of the brain to activate meningeal nociceptors.
Problems with this theory:
Two-thirds of patients with migraine do not experience aura (silent CSD?)
Aura may occur simultaneously with headache
And aura may occur in isolation (without headache).
Tension-Type Headache
Pericranial myofascial tissues are more tender in tension-type headache
Tenderness is related to both intensity and frequency of attacks
Multiple electromyographic (EMG) studies have demonstrated normal or slightly increased muscle activity intenstion-type headache
Trigeminal Autonomic Cephalalgias
never on the other side
eyes = color changes and watering of eye
> lid can drop
nose = either runny or stuffy
unilateral facial sweating
only on side of headache
Trigeminal Autonomic Cephalalgias
4 stages:
short lasting unilateral headaches
paroxysmal hermicrania
cluster headache
HC
short lasting unilateral headaches
1-600sec./1-100 attacks daily
paroxysmal hermicrania
2-30 mins./1-40 attacks daily
cluster headache
15-180 mins./1-8 attacks daily
HC
continuous with exacerbation
duration of 3 months
Others
Primary cough headache
Primary exercise headache
Primary headache associated with sexual activity
Primary thunderclap headache
Cold-stimulus headache
External-pressure headache
Primary stabbing headache
Nummular headache
Hypnic headache
New daily persistent headache
Primary cough headache
valsava
heavy lifting