Hardy-Weinberg Law

Question 1

In a gene which only has 2 alleles what must p + q =?

Answer 1

1

Question 2

What symbol demonstrates homozygous dominant (AA)?

Answer 2

p^2

Question 3

What symbol represents heterozygocity (Aa)?

Answer 3

2pq

Question 4

What is the symbol represents homozygous recessive (aa)?

Answer 4

q^2

Question 5

What is the general equation of the Hardy-Weinberg Law?

Answer 5

p^2 + 2pq + q^2

Question 6

What are the assumptions that are key to the Hardy-Weinberg Law?

Answer 6

• Large population
• Completely random mating
• No mutations
• No migration in/out of population
• No natural selection

Question 7

If the assumptions of the Hardy-Weinberg Law are met what does this mean for the population?

Answer 7

The allele frequencies will not change from one generation to the next
- Known as the Hardy-Weinberg equilibrium

Question 8

What can the Hardy-Weinberg Law be useful in determining?

Answer 8

Frequency of aut recessive diseases

Question 9

Question:
Disease X is aut recessive.
Disease X occurs in 1/4500 children (q^2)

What is the carrier frequency (2pq)?

Answer 9

3%

Question 10

If p is close to 1 will the AR disease be rare or common?

Answer 10

Rare

Question 11

If 2pq almost equals 2q what does this mean about the frequency of the AR disease?

Answer 11

Very rare

Question 12

In X linked diseases
What will p and q represent in men?

Answer 12

p will simply represent healthy males and q diseased (as there is no other allele)

Question 13

p and q will have the same allele frequencies in men and women in X linked disease

Answer 13

True

Question 14

Among females how is the rate of X-linked recessive disease (rate of recessive genes determined)?

Answer 14

Using the Hardy Weinberg principle like it is any other AR disease

• p^2 + 2pq + q^2