Ethanol Metabolism Flashcards
1
Q
What drug inhibits alcohol/ethanol dehdrogenase?
A
Fomepizole
2
Q
What drug inhibits acetaldehyde dehydrogenase?
A
Disulfiram
3
Q
What substance is responsible for the majority of ‘hangover’ symptoms?
A
Acetaldehyde
4
Q
What is responsible for the majority of metabolic disorders with alcohol use?
A
An increase in the NADH to NAD+ ratio
5
Q
What does an increase in NADH to NAD+ ratio cause?
A
- Decreased gluconeogenesis (fasting hypoglycemia)
- Decreased TCA cycle (ketosis - acetyl CoA use)
- Lactic acidosis (pyruvate converted to lactate to use NADH)
6
Q
What drug causes the patient to have severe hangover-like symptoms?
A
Disulfrim (due to build-up of acetaldehyde)
7
Q
What is fomepizole used to treat clinically?
A
Methanol and ethylene glycol poisoning
