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SFM > Hardass Immuno > Flashcards

Hardass Immuno Flashcards

1
Q

IL-12 stims

A

Th1

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2
Q

IL-4 stims

A

Th2

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3
Q

TGF-B and IL-6 stim

A

Th17

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4
Q

Naive T cell adhesion molecules

A

LFA-1 and VLA-4

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5
Q

T cell chemokine receptor

A

CCR7

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6
Q

DCs maturation response to T cells

A

Up-regulate CCR7
Increase expression of CD80 (B7)
Travel to secondary lymph tissue

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7
Q

What cell can activate naive t cells

A

DC

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8
Q

First signal for T cell activation (T cell response)

A

Increase CD40L

Increase CD28

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9
Q

First signal for T cella ctivation (APC response)

A 
Increase CD40
Increase CD80 (B7)
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10
Q

What makes a T cell anergic

A

Not activated b/c co-stim igands are not working

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11
Q

What does binding of IL-2 to IL-2R do

A

Promote T proliferation and differentiation

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12
Q

Cytokines for Th1

A

IFN-y and IL-12

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13
Q

Cytokines for Th2

A

IL-4, 5, 13

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14
Q

Cytokines for Th17

A

TGF-B, IL-17 and IL-22

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15
Q

Cytokines for Tfh

A

IL-21

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16
Q

Cross presentation is necessary for ___ activation

A

CD8

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17
Q

Once activated T cells start expressing

A

CTLA-4

18
Q

Novel TF for T reg CD4 cells

A

FOXp3

19
Q

Treg secrete the cytokines

A

IL-10 and TGF-B

20
Q

What is needed for CTLs to respond to an antigen

A

Nothing

21
Q

Th1 secrete

A

IL-2 and IFN-y

22
Q

Th1 function

A

Activate DC, macro and NK

23
Q

Th1 TF

A

T-bet

24
Q

Th2 activated by

A

IL-4

25
Q

Th2 responds to

A

Allergens and helminths

26
Q

Th2 TF

A

GATA-3

27
Q

Th2 secretes

A

IL-4, 5 ,13

28
Q

Th2 aids in stimulating what Ig

A

IgE

29
Q

Th1 vs Th2 macro activation

A 
1= classical 
2= alternative
30
Q

Is Th1 or Th1 better against intracell microbes

A

Th1

31
Q

Th17 responds to

A

Il-1 and IL-6

Bacteria and fungus

32
Q

Th17 TF

A

ROR y t

33
Q

Th17 secretes

A

IL-17 and 22

34
Q

Th17 main function

A

Barrier function and neutrophil activation

35
Q

CCR7 on T cell binds

A

CCL29 or 21

36
Q

LFA-1 on T cell binds

A

Icam-1

37
Q

Is L-selectin in neutrophil or endothelial

A

Neutrophil

38
Q

What Th cells enhance CTL response

A

Th1 via IL-2

39
Q

2 methods of CTL killing

A

Cytotoxins or FasL/Fas (CD95)

40
Q

Cytokines that enhance NK cells

A

IFN-a, IFN-B and IL-12

41
Q

What do ADCC recognize

A

IgG or IgE

42
Q

Cytokines required for Memory T cell survival

A

IL-7 and IL-15

SFM (4 decks)

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